Psychedelic drug could lift spirits in final years
NCT ID NCT05403086
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether psilocybin therapy can reduce demoralization in adults with a life expectancy of two years or less. One hundred participants will receive either psilocybin or an active control (ketamine) in a triple-blind design. The goal is to see if this approach safely improves emotional well-being in palliative care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (a psychedelic drug)
What this could lead to
If it works, this could offer a new way to ease deep distress and improve quality of life for people near the end of life.
What could go wrong
This is a mid-stage trial with only 100 people, so results may not apply to everyone. Psychedelic therapy can cause temporary confusion or emotional discomfort.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
RECRUITINGTorrance, California, 90502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Marin Cancer Care
RECRUITINGGreenbrae, California, 94904, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sunstone Therapies
RECRUITINGRockville, Maryland, 20850, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of San Francisco
RECRUITINGSan Francisco, California, 94518, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••