Magic mushroom compound tested for severe OCD

NCT ID NCT05370911

First seen Feb 28, 2026 · Last updated May 11, 2026 · Updated 14 times

Summary

This study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). It involves 30 adults with severe OCD who have not improved with standard treatments. Participants receive psilocybin in a controlled setting, and researchers measure changes in OCD severity using a standard scale.

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Contacts and locations

Locations

  • Enact Research Collaborative (40 Temple St, 4th Floor)

    New Haven, Connecticut, 06510, United States

  • Yale Program for Psychedelic Research

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.