New drug trial targets scarring in rare liver disease

NCT ID NCT04480840

Completed Disease control Sponsor: Pliant Therapeutics, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested the safety and correct dosage of an experimental drug called PLN-74809 in people with primary sclerosing cholangitis (PSC), a rare disease that scars the liver's bile ducts. 121 participants received either the drug or a placebo for 12 to 48 weeks to see how their bodies handled it and to check for side effects. The main goal was to find a safe dose for future studies, not to cure the disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

(G.I.R.I) GI Research Institute

Vancouver, British Columbia, V6Z 2K5, Canada
Amsterdam UMC

Amsterdam, 1105 AZ, Netherlands
Aspen Woods Clinic

Calgary, Alberta, T3H 0V5, Canada
Baylor College of Medicine - Advanced Liver Therapies

Houston, Texas, 77030, United States
Bon Secours Liver Institute of Hampton Roads

Newport News, Virginia, 23602, United States
C.H.U. Hautepierre

Strasbourg, 67200, France
CHU Grenoble Alpes - Hôpital Michallon

Grenoble, 38043 CEDEX 9, France
CHU de Lille service MAD

Lille, 59037, France
California Liver Research Institute

Pasadena, California, 91105, United States
California Pacific Medical Center Research Institute

San Francisco, California, 94109, United States
Centre Hépato-Biliaire - Hôpital Paul-Brousse

Villejuif, 94800, France
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM)

Montreal, Quebec, H2X 0A9, Canada
Charité University Medicine Berlin

Berlin, 13353, Germany
Department Gastroenterology, Hepatopancreatology and Digestive Oncology CUB Hôpital Erasme

Brussels, 1070, Belgium
Duke University Medical Center

Durham, North Carolina, 27710, United States
Erasmus University Medical Center

Rotterdam, 3015 GD, Netherlands
Florida Research Institute

Lakewood Rch, Florida, 34211, United States
Ghent University Hospital

Ghent, 9000, Belgium
Henry Ford Health System

Novi, Michigan, 48377, United States
Indiana University Health University Hospital

Indianapolis, Indiana, 46202, United States
John Radcliffe Hospital/Oxford University Hospital

Headington, Oxford, OX3 9DU, United Kingdom
King's College Hospital NHS Foundation Trust, Denmark Hill

London, SE5 9RS, United Kingdom
Leiden University Medical Center

Leiden, 2333 ZA, Netherlands
Liver Institute Northwest

Seattle, Washington, 98105, United States
Liverpool Hospital: Department of Gastroenterology and Hepatology

Liverpool, New South Wales, 2170, Australia
London Health Sciences Centre-University Hospital

London, Ontario, N6A 5A5, Canada
Massachusetts General Hospital Gastroenterology Liver Center

Boston, Massachusetts, 02114, United States
McGill University Health Centre

Montreal, Quebec, H4A3J1, Canada
McMaster University Medical Centre

Hamilton, Ontario, L8N 3Z5, Canada
Medical University of Vienna Div. of Gastroenterology and Hepatology

Vienna, A-1090, Austria
Medizinische Universität Graz

Graz, 8036, Austria
Norfolk and Norwich University Hospitals NHS Foundation Trust

Norwich, Norfolk, NR4 7UY, United Kingdom
Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19104, United States
Piedmont Atlanta Hospital

Atlanta, Georgia, 30309, United States
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
Saint Antoine Hospital/ Hepatology Department

Paris, 75012, France
Schiff Center of Liver Diseases/University of Miami

Miami, Florida, 33136, United States
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
St. Vincent's Hospital

Melbourne, Victoria, 3065, Australia
Stanford University School of Medicine

Redwood City, California, 94063, United States
The Alfred

Melbourne, Victoria, 3004, Australia
The Ottawa Hospital

Ottawa, Ontario, K1H 8L6, Canada
Toronto Centre for Liver Disease (TCLD), University Health Network, Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada
UZ Leuven

Leuven, 3000, Belgium
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
University Hospital Erlangen

Erlangen, 91054, Germany
University Hospital Heidelberg

Heidelberg, 69120, Germany
University Hospitals Birmingham NHS

Birmingham, B15 2GW, United Kingdom
University Medical Center Hamburg -Eppendorf/ I. Dept of Medicine

Hamburg, 20246, Germany
University of Alberta Hospital - Walter C. Mackenzie Health Sciences Centre

Edmonton, Alberta, T6G 2X8, Canada
University of California San Francisco

San Francisco, California, 94143, United States
University of California, Davis Medical Center

Sacramento, California, 95817, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Universitätsmedizin Mainz, I. Med. Klinik

Mainz, 55131, Germany
VCU Health Clinical Research Services Unit

Richmond, Virginia, 23298, United States
Vanderbilt Digestive Disease Center

Nashville, Tennessee, 37232, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Yale School of Medicine

New Haven, Connecticut, 06511, United States

Conditions

Explore the condition pages connected to this study.

PRIMARY SCLEROSING CHOLANGITIS