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Can a flu shot change a Doctor's judgment?

NCT ID NCT07842367

Knowledge-focused Sponsor: University of Arkansas, Fayetteville Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Oct 01, 2026 · Updated 2 times

Summary

Researchers want to know whether mild inflammation, like what happens after a flu shot, affects how healthcare providers make decisions about patients. The trial enrolls emergency medicine and internal medicine providers who receive either a seasonal influenza vaccine or a saline placebo. Over two days, participants give blood samples and complete computer tasks and questionnaires that measure automatic and deliberate judgments about patient groups. The goal is to see if short-term illness or stress shifts medical decision-making.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
seasonal influenza vaccine or saline placebo injection
What this could lead to
If inflammation changes how providers judge patients, hospitals could adjust schedules or support during illness to protect decision quality.
What could go wrong
This small, early-phase study uses a vaccine to mimic mild illness, so the inflammation is brief and may not reflect real burnout or severe illness. Results may not apply to all providers or real clinical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthcare providers currently employed in emergency medicine or internal medicine * Must be one of the following: Resident, fellow, attending, or advanced practice provider (NP, PA) * Individual is able to travel to the research site for sessions * Has not had an acute viral or bacterial infection within the previous 14 days * Has not taken an antiviral medication such as Tamiflu in the previous 48 hours * Has not taken corticosteroids or immunosuppressants in the previous 30 days Exclusion Criteria: * Does not want to receive a flu vaccine as part of the study * Has received a flu vaccine this season already (after August of current year) * Has had a prior allergic reaction or bad side effect, including Guillain-Barre, due to a flu vaccine or another vaccine * Is allergic to eggs or have had an adverse reaction to egg-derived vaccine * Is pregnant or suspects a possible pregnancy * Has congenital or acquired immunodeficiency such as common variable immunodeficiency (CVID) or HIV/AIDS * Has an active hematologic malignancy (like leukemia, lymphoma, myeloma) * Has Type 1 diabetes * Has Graft vs. Host Disease * Uses aspirin, ibuprofen (i.e., NSAIDs), acetaminophen, or naproxen daily * Uses corticosteroids or immunosuppressants daily * Is currently receiving systemic chemotherapy and/or immunotherapy * Has had changes in daily prescription medication in the last 3 months (starting, stopping, changing dose)

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Decision making Patient care Treatment decisions

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Carilion Medical Center

    RECRUITING

    Roanoke, Virginia, 24016, United States

  • University of Arkansas for Medical Sciences

    RECRUITING

    Fayetteville, Arkansas, 72703, United States

  • University of New Mexico Health Sciences Center

    RECRUITING

    Albuquerque, New Mexico, 87106, United States

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