Proton beam vs X-Ray: which radiation is better for liver cancer?

NCT ID NCT03186898

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times

Summary

This study compares two types of radiation therapy for people with liver cancer that cannot be removed by surgery or has come back. One type uses standard X-rays (photons), while the other uses proton beams, which may cause less harm to healthy organs nearby. The goal is to see if proton therapy helps patients live longer and with fewer side effects. About 186 adults with liver cancer are taking part in this phase 3 trial.

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Contacts and locations

Locations

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan, 48085, United States

  • Corewell Health Dearborn Hospital

    Dearborn, Michigan, 48124, United States

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan, 48073, United States

  • Emory Proton Therapy Center

    Atlanta, Georgia, 30308, United States

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Maryland Proton Treatment Center

    Baltimore, Maryland, 21201, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    East White Plains, New York, 10604, United States

  • New York Proton Center

    New York, New York, 10035, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Cincinnati Cancer Center-West Chester

    West Chester, Ohio, 45069, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.