Proton vs. photon: race to find safer radiation for esophageal cancer

NCT ID NCT03801876

Recruiting now Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

Summary

This study aims to find out if proton beam radiation therapy works better and causes fewer serious heart and lung side effects than the standard photon radiation therapy for people with esophageal cancer. About 300 patients with stage I-IVA esophageal cancer will be randomly assigned to receive one of the two radiation types, along with chemotherapy, and possibly surgery. Researchers will track survival, side effects, and quality of life to see which treatment is more effective and safer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alton Memorial Hospital
RECRUITING

Alton, Illinois, 62002, United States

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Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

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Corewell Health Beaumont Troy Hospital
RECRUITING

Troy, Michigan, 48085, United States

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Corewell Health Dearborn Hospital
RECRUITING

Dearborn, Michigan, 48124, United States

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Corewell Health William Beaumont University Hospital
RECRUITING

Royal Oak, Michigan, 48073, United States

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Emory Proton Therapy Center
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30308, United States
Emory Saint Joseph's Hospital
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30322, United States
Geauga Hospital
RECRUITING

Chardon, Ohio, 44024, United States

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Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States

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Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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Inova Alexandria Hospital
ACTIVE_NOT_RECRUITING

Alexandria, Virginia, 22304, United States
Inova Fair Oaks Hospital
ACTIVE_NOT_RECRUITING

Fairfax, Virginia, 22033, United States
Inova Loudoun Hospital
ACTIVE_NOT_RECRUITING

Leesburg, Virginia, 20176, United States
Inova Schar Cancer Institute
ACTIVE_NOT_RECRUITING

Fairfax, Virginia, 22031, United States
Karmanos Cancer Institute at McLaren Greater Lansing
RECRUITING

Lansing, Michigan, 48910, United States

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M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

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MD Anderson League City
RECRUITING

League City, Texas, 77573, United States

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MD Anderson West Houston
RECRUITING

Houston, Texas, 77079, United States

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MD Anderson in Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States

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MD Anderson in The Woodlands
RECRUITING

Conroe, Texas, 77384, United States

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Maryland Proton Treatment Center
RECRUITING

Baltimore, Maryland, 21201, United States

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Massachusetts General Hospital Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States

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Mayo Clinic Health System in Albert Lea
COMPLETED

Albert Lea, Minnesota, 56007, United States
Mayo Clinic Health System-Eau Claire Clinic
COMPLETED

Eau Claire, Wisconsin, 54701, United States
Mayo Clinic Health Systems-Mankato
COMPLETED

Mankato, Minnesota, 56001, United States
Mayo Clinic Hospital in Arizona
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Radiation Therapy-Northfield
ACTIVE_NOT_RECRUITING

Northfield, Minnesota, 55057, United States
Mayo Clinic in Arizona
ACTIVE_NOT_RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
McLaren Cancer Institute-Bay City
RECRUITING

Bay City, Michigan, 48706, United States

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McLaren Cancer Institute-Flint
RECRUITING

Flint, Michigan, 48532, United States

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McLaren Cancer Institute-Lapeer Region
RECRUITING

Lapeer, Michigan, 48446, United States

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McLaren Cancer Institute-Owosso
RECRUITING

Owosso, Michigan, 48867, United States

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Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States

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Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Mercy Cancer Center-Elyria
SUSPENDED

Elyria, Ohio, 44035, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

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Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States

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Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States

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Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States

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New York Proton Center
RECRUITING

New York, New York, 10035, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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Orlando Health Cancer Institute
ACTIVE_NOT_RECRUITING

Orlando, Florida, 32806, United States
Ridgeview Medical Center
RECRUITING

Waconia, Minnesota, 55387, United States

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Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

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Thompson Cancer Survival Center
RECRUITING

Knoxville, Tennessee, 37916, United States

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Thompson Cancer Survival Center - West
RECRUITING

Knoxville, Tennessee, 37932, United States

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Thompson Oncology Group-Maryville
SUSPENDED

Maryville, Tennessee, 37804, United States
Thompson Oncology Group-Oak Ridge
RECRUITING

Oak Ridge, Tennessee, 37830, United States

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Thompson Proton Center
RECRUITING

Knoxville, Tennessee, 37909, United States

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UH Seidman Cancer Center at Firelands Regional Medical Center
RECRUITING

Sandusky, Ohio, 44870, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at Landerbrook Health Center
RECRUITING

Mayfield Heights, Ohio, 44124, United States

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UH Seidman Cancer Center at Saint John Medical Center
SUSPENDED

Westlake, Ohio, 44145, United States
UH Seidman Cancer Center at Southwest General Hospital
RECRUITING

Middleburg Heights, Ohio, 44130, United States

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UH Seidman Cancer Center at UH Avon Health Center
RECRUITING

Avon, Ohio, 44011, United States

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UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

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UHHS-Westlake Medical Center
RECRUITING

Westlake, Ohio, 44145, United States

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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States

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UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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UM Upper Chesapeake Medical Center
ACTIVE_NOT_RECRUITING

Bel Air, Maryland, 21014, United States
Unity Hospital
ACTIVE_NOT_RECRUITING

Fridley, Minnesota, 55432, United States
University Hospitals Parma Medical Center
RECRUITING

Parma, Ohio, 44129, United States

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University Hospitals Portage Medical Center
RECRUITING

Ravenna, Ohio, 44266, United States

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University Hospitals Sharon Health Center
RECRUITING

Wadsworth, Ohio, 44281, United States

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University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

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University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

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University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

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University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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University of Washington Medical Center - Montlake
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98195, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

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Conditions

Explore the condition pages connected to this study.