New hope for kids with brain tumor: less surgery, smarter radiation
NCT ID NCT01419067
First seen Oct 31, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This study tests whether using a smaller radiation target area with proton therapy, after limited surgery, can control craniopharyngioma while reducing side effects in children and young adults. Some patients who had complete tumor removal are simply watched without radiation. The goal is to find a safer treatment that still keeps the tumor from growing back.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of Florida Health Proton Therapy Institute
Jacksonville, Florida, 32206, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
proton therapy
What this could lead to
If successful, this approach could offer a way to treat craniopharyngioma with fewer side effects than standard radiation, while still controlling tumor growth.
What could go wrong
This is a phase II trial with a moderate number of participants, so results are not definitive. The reduced radiation margin might increase the risk of tumor progression, and long-term outcomes are still unknown.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.