New hope for advanced prostate cancer? early trial tests targeted combo therapy

NCT ID NCT05818683

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This early-phase study is testing a new drug called pasritamig (JNJ-78278343) combined with other treatments for men with metastatic prostate cancer that no longer responds to hormone therapy. The goal is to find the safest and most effective dose. About 300 participants will be enrolled to monitor side effects and see if the combination can shrink tumors or lower PSA levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC CASTRATION-RESISTANT PROSTATE CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-RESISTANT PROSTATE NEOPLASMS METASTATIC HORMONE-SENSITIVE PROSTATE CANCER

Contacts and locations

Locations

Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Hosp Univ Fund Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hosp Univ Hm Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 8035, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Icon Cancer Centre Kurralta Park
RECRUITING

Kurralta Park, 5037, Australia
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Macquarie University
RECRUITING

Macquarie University, 2109, Australia
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Perlmutter Cancer Center at NYU Langone Brooklyn
RECRUITING

Brooklyn, New York, 11223, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Sidney Kimmel Cancer Center - Jefferson Health
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Start Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.