New hope to delay cancer progression in advanced prostate cancer

NCT ID NCT04493853

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding an experimental drug called capivasertib to standard hormone therapy (abiraterone) works better for men whose prostate cancer has already spread and has a specific genetic feature (PTEN deficiency). The main goal is to see if the new combination can delay the cancer from getting worse or spreading further for a longer time compared to the standard treatment alone. Researchers will also closely monitor side effects and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Tucson, Arizona, 85723, United States
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Tucson, Arizona, 85741, United States
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La Jolla, California, 92037, United States
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Orange, California, 92868, United States
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San Diego, California, 92123, United States
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Denver, Colorado, 80211, United States
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Lakewood, Colorado, 80215, United States
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Norwich, Connecticut, 06360, United States
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Fort Myers, Florida, 33901-8101, United States
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West Palm Beach, Florida, 33401, United States
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Chicago, Illinois, 60637, United States
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Geneva, Illinois, 60134, United States
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Lisle, Illinois, 60532, United States
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Baltimore, Maryland, 21201, United States
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Detroit, Michigan, 48201, United States
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Grand Rapids, Michigan, 49503, United States
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Troy, Michigan, 48084, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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Asheville, North Carolina, 28805, United States
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Durham, North Carolina, 27710, United States
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Columbus, Ohio, 43210, United States
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Lancaster, Pennsylvania, 17601, United States
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Philadelphia, Pennsylvania, 19111, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Charleston, South Carolina, 29401, United States
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Myrtle Beach, South Carolina, 29572, United States
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Chattanooga, Tennessee, 37404, United States
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Houston, Texas, 77090, United States
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Norfolk, Virginia, 23502, United States
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Roanoke, Virginia, 24014, United States
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Seattle, Washington, 98104, United States
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Madison, Wisconsin, 53792, United States
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Berazategui, B1884BBF, Argentina
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Buenos Aires, 1426, Argentina
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CABA, 1425, Argentina
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CABA, C1012AAR, Argentina
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Ciudad de Buenos Aires, C1120AAT, Argentina
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Ciudad de Buenos Aires, C1280AEB, Argentina
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La Plata, 1900, Argentina
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Mendoza, 5500, Argentina
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Rosario, S2000DEJ, Argentina
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San Salvador de Jujuy, 4600, Argentina
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Birtinya, 4575, Australia
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Darlinghurst, 2010, Australia
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Kingswood, 2747, Australia
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Orange, 2800, Australia
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South Brisbane, 4101, Australia
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Graz, 8036, Austria
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Linz, 4020, Austria
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Salzburg, 5020, Austria
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Anderlecht, 1070, Belgium
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Ghent, 9000, Belgium
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Kortrijk, 8500, Belgium
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Liège, 4000, Belgium
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Belém, 66073-005, Brazil
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Belo Horizonte, 30110-022, Brazil
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Florianópolis, 88020-210, Brazil
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Fortaleza, 60135-237, Brazil
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Jaú, 17210-120, Brazil
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Joinville, 89201-260, Brazil
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Porto Alegre, 90035-000, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 90160-093, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio de Janeiro, 20230-130, Brazil
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Santa Maria, 97015-450, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01327-001, Brazil
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Três Lagoas, 79601-001, Brazil
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Pleven, 5804, Bulgaria
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Plovdiv, 4004, Bulgaria
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Plovdiv, 4109, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1527, Bulgaria
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Sofia, 1756, Bulgaria
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Sofia, 1797, Bulgaria
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Varna, 9000, Bulgaria
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Calgary, Alberta, T2N 5G2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Vancouver, British Columbia, V5Z 1H7, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, H3T 1E2, Canada
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Santiago, 7500653, Chile
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Santiago, 7500787, Chile
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Santiago, 8420383, Chile
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Temuco, 4781156, Chile
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Viña del Mar, 2540488, Chile
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Beijing, 100034, China
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Beijing, 100036, China
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Beijing, 100050, China
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Beijing, CN-100730, China
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Changchun, 130021, China
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Changsha, 410003, China
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Changsha, 410008, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400030, China
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Chongqing, 400038, China
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Fuzhou, 350001, China
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Fuzhou, 350005, China
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Guangzhou, 510060, China
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Guangzhou, 510180, China
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Guangzhou, 510515, China
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Guiyang, 550002, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Hangzhou, 310052, China
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Kunming, 650118, China
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Nanchang, 330006, China
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Nanjing, 2100008, China
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Nanjing, 210009, China
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Nantong, 226361, China
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Ningbo, 315000, China
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Shanghai, 200032, China
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Shanghai, 200080, China
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Shanghai, 200127, China
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Shengyang, 110004, China
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Tianjin, 300211, China
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Wenzhou, CN-325000, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Yantai, 264000, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Brno, 656 91, Czechia
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Hořovice, 268 31, Czechia
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Hradec Králové, 500 05, Czechia
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Prague, 100 34, Czechia
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Prague, 120 00, Czechia
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Prague, 180 81, Czechia
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Besançon, 25030, France
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Bordeaux, 33076, France
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Marseille, 13273, France
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Montpellier, 34298, France
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Nice, 06100, France
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Paris, 75674, France
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Pierre-Bénite, 69495, France
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Quimper, 29107, France
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Rennes, 35033, France
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Strasbourg, 67098, France
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Suresnes, 92151, France
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Villejuif, 94805, France
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Berlin, 10117, Germany
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Duisburg, 47169, Germany
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Hamburg, 20246, Germany
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Herne, 44625, Germany
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Mettmann, 40822, Germany
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Münster, 48149, Germany
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Nuremberg, 90419, Germany
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Nürtingen, 72622, Germany
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Wesel, 46483, Germany
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Hong Kong, 00000, Hong Kong
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Hong Kong, Hong Kong
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Lai Chi Kok, Hong Kong
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Ahmedabad, 380060, India
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Bangalore, 560022, India
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Bangalore, 560027, India
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Delhi, 110085, India
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Faridabad, 121001, India
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Kanpur, 208005, India
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Kolkata, 700160, India
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Madurai, 625107, India
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Manipal, 576104, India
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Meerut, 250001, India
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Mohali, 160055, India
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Nagpur, 440001, India
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New Delhi, 110005, India
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New Delhi, 11029, India
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Thiruvananthapuram, 695 011, India
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Varanasi, 221005, India
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 95847, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 52621, Israel
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Ẕerifin, 70300, Israel
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Bunkyō City, 113-8431, Japan
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Chiba, 260-8677, Japan
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Chūōku, 260-8717, Japan
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Fukuoka, 812-8582, Japan
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Hamamatsu, 431-3192, Japan
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Hirakata-shi, 573-1191, Japan
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Hirosaki-shi, 036-8563, Japan
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Isehara-shi, 259-1193, Japan
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Kanazawa, 920-8641, Japan
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Kashihara-shi, 634-8522, Japan
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Kawagoe-shi, 350-8550, Japan
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Kisarazu-shi, 292-8535, Japan
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Kita-gun, 761-0793, Japan
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Kobe, 650-0047, Japan
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Kumamoto, 860-0008, Japan
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Kyoto, 606-8507, Japan
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Miyazaki, 889-1692, Japan
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Morioka, 028-3695, Japan
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Nagano, 381-8551, Japan
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Nagasaki, 852-8501, Japan
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Nagoya, 466-8560, Japan
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Nagoya, 466-8650, Japan
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Natori-shi, 981-1293, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Ota Shi, 373-8550, Japan
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Sagamihara-shi, 252-0375, Japan
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Sapporo, 060-8648, Japan
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Shinjuku-ku, 160-8582, Japan
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Toon-shi, 791-0295, Japan
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Tsu, 514-8507, Japan
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Ube-shi, 755-8505, Japan
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Yokohama, 232-0024, Japan
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Yokosuka-shi, 238-8558, Japan
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Yufu-shi, 879-5593, Japan
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Culiacán, 80040, Mexico
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Culiacán, 80230, Mexico
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Guadalajara, 44680, Mexico
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Mexico City, 0 3100, Mexico
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Monterrey, 64460, Mexico
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Monterrey, 64710, Mexico
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Amsterdam, 1066 CX, Netherlands
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Hilversum, 1213 XZ, Netherlands
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Roosendaal, 4708 AE, Netherlands
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The Hague, 2545 CH, Netherlands
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Tilburg, 5042AD, Netherlands
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Utrecht, 3543 AZ, Netherlands
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Callao, CALLAO 02, Peru
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Lima, 0051, Peru
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Lima, LIMA 29, Peru
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Lima, LIMA 31, Peru
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Lima, Lima 32, Peru
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Lima, LIMA 34, Peru
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San Isidro, 27, Peru
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Baguio City, 2600, Philippines
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Cebu City, 6000, Philippines
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Davao City, 8000, Philippines
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Iloilo City, 5000, Philippines
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Quezon City, 1101, Philippines
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Quezon City, 1112, Philippines
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San Juan City, 1500, Philippines
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Bydgoszcz, 85-796, Poland
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Gdansk, 80-952, Poland
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Koszalin, 75-581, Poland
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Lodz, 90-242, Poland
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Olsztyn, 10-228, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-055, Poland
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Torun, 87-100, Poland
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Warsaw, 02-781, Poland
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Warsaw, 04-073, Poland
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Moscow, 105077, Russia
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Moscow, 117997, Russia
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Moscow, 121205, Russia
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Novisibirsk, 630082, Russia
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Novosibirsk, 630007, Russia
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Saint Petersburg, 190103, Russia
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Saint Petersburg, 191014, Russia
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Yaroslavl, 150054, Russia
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Bratislava, 81102, Slovakia
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Bratislava, 851 05, Slovakia
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Martin, 036 59, Slovakia
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Nitra, 49401, Slovakia
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Prešov, 08001, Slovakia
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Šaľa, 92701, Slovakia
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Trenčín, 911 01, Slovakia
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Cape Town, 7570, South Africa
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Johannesburg, 2013, South Africa
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Johannesburg, 2193, South Africa
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Parow, 7505, South Africa
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Port Elizabeth, 6045, South Africa
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Pretoria, 0084, South Africa
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Daegu, 41404, South Korea
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Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Badalona (Barcelona), 08916, Spain
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Barcelona, 08041, Spain
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Las Palmas de Gran Canaria, 35016, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Oviedo, 33011, Spain
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Santander, 39008, Spain
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Seville, 41009, Spain
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Kaohsiung City, 807, Taiwan
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Kaohsiung City, 81362, Taiwan
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Taichung, 404, Taiwan
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Taichung, 43503, Taiwan
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Tainan, 710, Taiwan
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Taipei, 112, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Lampang, 52000, Thailand
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Muang, 22000, Thailand
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Ankara, 06010, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Antalya, 07059, Turkey (Türkiye)
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Eskişehir, 26040, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35575, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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Guildford, GU2 7XX, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Whitchurch, CF14 2TL, United Kingdom
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

HORMONE SENSITIVE PROSTATE CANCER