New Two-Drug combo trial offers hope for men with Tough-to-Treat prostate cancer

NCT ID NCT04446117

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

Summary

This study is for men with advanced prostate cancer that has spread and is no longer responding well to standard hormone therapy. It compares a new two-drug combination (cabozantinib and atezolizumab) against a second round of standard hormone therapy. The main goals are to see if the new combination helps patients live longer and keeps the cancer from growing for a longer time.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Exelixis Clinical #261

Rosario, Santa Fe Province, S2000KZE, Argentina
Exelixis Clinical #262

Geelong, Victoria, 3220, Australia
Exelixis Clinical #263

Santiago, Santiago Metropolitan, 7500787, Chile
Exelixis Clinical #264

Taipei, 11217, Taiwan
Exelixis Clinical #265

Taoyuan District, 333, Taiwan
Exelixis Clinical #266

Kaohsiung City, 81362, Taiwan
Exelixis Clinical #267

Parma, 43126, Italy
Exelixis Clinical #268

Lodz, 93-513, Poland
Exelixis Clinical #269

Pisa, 56126, Italy
Exelixis Clinical #270

Málaga, 29010, Spain
Exelixis Clinical Site # 189

Sydney, New South Wales, 2109, Australia
Exelixis Clinical Site #1

Nashville, Tennessee, 37209, United States
Exelixis Clinical Site #10

Tbilisi, 0144, Georgia
Exelixis Clinical Site #100

Akita, Akita, 010-8543, Japan
Exelixis Clinical Site #101

San Salvador de Jujuy, Y4600EHA, Argentina
Exelixis Clinical Site #102

Dnipro, 49005, Ukraine
Exelixis Clinical Site #103

Launceston, Tasmania, 7250, Australia
Exelixis Clinical Site #104

Hirosaki, Aomori, 036-8563, Japan
Exelixis Clinical Site #105

La Rioja, F5300, Argentina
Exelixis Clinical Site #106

São José do Rio Preto, São Paulo, 15090-000, Brazil
Exelixis Clinical Site #107

Perugia, 06132, Italy
Exelixis Clinical Site #108

Miami, Florida, 33125, United States
Exelixis Clinical Site #109

Budapest, 1145, Hungary
Exelixis Clinical Site #11

Tbilisi, 0159, Georgia
Exelixis Clinical Site #110

Braga, 4710-243, Portugal
Exelixis Clinical Site #111

Tainan, 704, Taiwan
Exelixis Clinical Site #112

Kelowna, British Columbia, V1Y 5L3, Canada
Exelixis Clinical Site #113

Temuco, 4810469, Chile
Exelixis Clinical Site #114

San Diego, California, 92161, United States
Exelixis Clinical Site #115

Adelaide, 5000, Australia
Exelixis Clinical Site #116

Santa Cruz do Sul, 96810-110, Brazil
Exelixis Clinical Site #117

Ramat Gan, 5265601, Israel
Exelixis Clinical Site #118

Budapest, 1062, Hungary
Exelixis Clinical Site #119

Valparaíso, 2540333, Chile
Exelixis Clinical Site #12

Manresa, Barcelona, 08243, Spain
Exelixis Clinical Site #120

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Exelixis Clinical Site #121

Florence, 50134, Italy
Exelixis Clinical Site #122

Ciudad Autonoma de Buenos Aire, Buenos Aires, C1280AEB, Argentina
Exelixis Clinical Site #123

East Brunswick, New Jersey, 08816, United States
Exelixis Clinical Site #124

San Juan, 5400, Argentina
Exelixis Clinical Site #125

Santa Monica, California, 90404, United States
Exelixis Clinical Site #126

Bonheiden, Antwerpen, 2820, Belgium
Exelixis Clinical Site #127

London, Ontario, N6A 5W9, Canada
Exelixis Clinical Site #128

Ribeirão Preto, São Paulo, 14048-900, Brazil
Exelixis Clinical Site #129

Brno, 656 91, Czechia
Exelixis Clinical Site #13

Madrid, 28050, Spain
Exelixis Clinical Site #130

Olomouc, 779 00, Czechia
Exelixis Clinical Site #131

Madrid, 28033, Spain
Exelixis Clinical Site #132

Blumenau, Santa Catarina, 89010-340, Brazil
Exelixis Clinical Site #133

Taichung, 407, Taiwan
Exelixis Clinical Site #134

Brest, 29229, France
Exelixis Clinical Site #135

Saint-Grégoire, 35760, France
Exelixis Clinical Site #136

Tübingen, 72076, Germany
Exelixis Clinical Site #137

Saint Petersburg, 197022, Russia
Exelixis Clinical Site #138

Kaohsiung City, 833, Taiwan
Exelixis Clinical Site #139

Santiago, Santiago Metropolitan, 7500921, Chile
Exelixis Clinical Site #14

Denver, Colorado, 80211, United States
Exelixis Clinical Site #140

Fortaleza, 60336-232, Brazil
Exelixis Clinical Site #141

Brussels, 1000, Belgium
Exelixis Clinical Site #142

Providencia, 7500713, Chile
Exelixis Clinical Site #143

Roanoke, Virginia, 24014, United States
Exelixis Clinical Site #144

Las Vegas, Nevada, 89169, United States
Exelixis Clinical Site #145

Ribeirão Preto, 14015-130, Brazil
Exelixis Clinical Site #146

Nîmes, 30029, France
Exelixis Clinical Site #147

Moncton, New Brunswick, E1C 6Z8, Canada
Exelixis Clinical Site #148

Recoleta, 8420383, Chile
Exelixis Clinical Site #149

Box Hill, 3128, Australia
Exelixis Clinical Site #15

Tbilisi, 0167, Georgia
Exelixis Clinical Site #150

Petah Tikva, 4941492, Israel
Exelixis Clinical Site #151

Garran, Australian Capital Territory, 2605, Australia
Exelixis Clinical Site #152

Viedma, Río Negro Province, R8500ACE, Argentina
Exelixis Clinical Site #153

Porto Alegre, 90110-270, Brazil
Exelixis Clinical Site #154

Barretos, 14784-400, Brazil
Exelixis Clinical Site #155

Dijon, 21079, France
Exelixis Clinical Site #156

Linz, Upper Austria, 4020, Austria
Exelixis Clinical Site #16

Tbilisi, 0112, Georgia
Exelixis Clinical Site #17

Alcorcón, Madrid, 28922, Spain
Exelixis Clinical Site #171

Rio de Janeiro, Rio de Janeiro, 22793-080, Brazil
Exelixis Clinical Site #172

Querétaro City, Querétaro, 76070, Mexico
Exelixis Clinical Site #173

Guadalajara, Jalisco, 44600, Mexico
Exelixis Clinical Site #174

Mexico City, 01120, Mexico
Exelixis Clinical Site #175

Saint Leonards, New South Wales, 2065, Australia
Exelixis Clinical Site #176

Nürtingen, Baden-Wurttemberg, 72622, Germany
Exelixis Clinical Site #177

Houston, Texas, 77030, United States
Exelixis Clinical Site #178

Granby, Quebec, J2GIT7, Canada
Exelixis Clinical Site #179

Münster, North Rhine-Westphalia, 48149, Germany
Exelixis Clinical Site #18

Philadelphia, Pennsylvania, 19111, United States
Exelixis Clinical Site #180

Duisburg, North Rhine-Westphalia, 47179, Germany
Exelixis Clinical Site #181

Singapore, 329563, Singapore
Exelixis Clinical Site #182

Querétaro City, Querétaro, 76230, Mexico
Exelixis Clinical Site #183

Rosario, Santa Fe Province, S2000CVB, Argentina
Exelixis Clinical Site #184

San Luis Potosí City, San Luis Potosí, 78209, Mexico
Exelixis Clinical Site #185

Lübeck, Schleswig-Holstein, 23538, Germany
Exelixis Clinical Site #186

Dnipro, 49102, Ukraine
Exelixis Clinical Site #187

Mexico City, Mexico City, 06760, Mexico
Exelixis Clinical Site #188

Guimarães, 4835-044, Portugal
Exelixis Clinical Site #19

Omaha, Nebraska, 68130, United States
Exelixis Clinical Site #190

Barcelona, 08041, Spain
Exelixis Clinical Site #191

Campinas, São Paulo, 13083-970, Brazil
Exelixis Clinical Site #192

Milan, 20132, Italy
Exelixis Clinical Site #193

Vila Real, 5000-508, Portugal
Exelixis Clinical Site #194

Swansea, Wales, SA2 Q8A, United Kingdom
Exelixis Clinical Site #195

Saint Petersburg, 197758, Russia
Exelixis Clinical Site #196

Loures, 2674-514, Portugal
Exelixis Clinical Site #197

Lisbon, 1500-650, Portugal
Exelixis Clinical Site #198

The Bronx, New York, 10461, United States
Exelixis Clinical Site #199

Trento, Trentino-Alto Adige, 38122, Italy
Exelixis Clinical Site #2

Fullerton, California, 92835, United States
Exelixis Clinical Site #20

Junggu, Daejeon, 35015, South Korea
Exelixis Clinical Site #200

Buenos Aires, C1426ANZ, Argentina
Exelixis Clinical Site #201

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #202

Marousi, Attica, 15123, Greece
Exelixis Clinical Site #203

Rochester, Minnesota, 55905, United States
Exelixis Clinical Site #204

Curitiba, Paraná, 80520-174, Brazil
Exelixis Clinical Site #205

London, England, SE1 9RT, United Kingdom
Exelixis Clinical Site #206

Tuxtla Gutiérrez, Chiapas, 29038, Mexico
Exelixis Clinical Site #207

Budapest, 1082, Hungary
Exelixis Clinical Site #208

Culiacán, Sinaloa, C.P. 80020, Mexico
Exelixis Clinical Site #209

Fukuoka, 815-8588, Japan
Exelixis Clinical Site #21

Daegu, 42601, South Korea
Exelixis Clinical Site #210

Córdoba, Córdoba Province, X5004FHP, Argentina
Exelixis Clinical Site #211

Natori-shi, Miyagi, 981-1293, Japan
Exelixis Clinical Site #212

Guadalajara, Jalisco, 44500, Mexico
Exelixis Clinical Site #213

Strasbourg, 67000, France
Exelixis Clinical Site #214

Reims, 51100, France
Exelixis Clinical Site #215

Westwood, Kansas, 66205, United States
Exelixis Clinical Site #216

Shizuoka, Shizuoka, 420-8527, Japan
Exelixis Clinical Site #217

Ancona, 60126, Italy
Exelixis Clinical Site #218

Vienna, 1080, Austria
Exelixis Clinical Site #219

Zapopan, Jalisco, 45040, Mexico
Exelixis Clinical Site #22

Yokohama, Kanagawa, 232-0024, Japan
Exelixis Clinical Site #220

Palma de Mallorca, Balearic Islands, 07120, Spain
Exelixis Clinical Site #221

Oklahoma City, Oklahoma, 73104, United States
Exelixis Clinical Site #222

La Roche-sur-Yon, 85925, France
Exelixis Clinical Site #223

Porto, 4200-072, Portugal
Exelixis Clinical Site #224

La Jolla, California, 92093-0698, United States
Exelixis Clinical Site #225

Oviedo, Principality of Asturias, 33011, Spain
Exelixis Clinical Site #226

Cadiz, 11407, Spain
Exelixis Clinical Site #227

Berlin, 10117, Germany
Exelixis Clinical Site #228

Barcelona, 08003, Spain
Exelixis Clinical Site #229

Elche, Alicante, 03203, Spain
Exelixis Clinical Site #23

Barcelona, 08035, Spain
Exelixis Clinical Site #230

Vandœuvre-lès-Nancy, 54511, France
Exelixis Clinical Site #231

Northwood, Middlesex, HA6 2RN, United Kingdom
Exelixis Clinical Site #232

Toyota-shi, Aichi-ken, 471-8513, Japan
Exelixis Clinical Site #233

Santiago de Compostela, La Coruna, 15706, Spain
Exelixis Clinical Site #234

Roma, 00168, Italy
Exelixis Clinical Site #235

Surrey Quays, England, SM2 5PT, United Kingdom
Exelixis Clinical Site #236

Madrid, 28041, Spain
Exelixis Clinical Site #237

Pavia, 27100, Italy
Exelixis Clinical Site #238

Athens, Attica, 11526, Greece
Exelixis Clinical Site #239

Hamburg, 20246, Germany
Exelixis Clinical Site #24

Busan, 49241, South Korea
Exelixis Clinical Site #240

Debrecen, 4032, Hungary
Exelixis Clinical Site #241

Taunton, England, TA1 5DA, United Kingdom
Exelixis Clinical Site #242

Louisville, Kentucky, 40202, United States
Exelixis Clinical Site #243

Otwock, Masovian Voivodeship, 05-400, Poland
Exelixis Clinical Site #244

Nea Kifissia, Attica, 14564, Greece
Exelixis Clinical Site #245

Stanford, California, 94305, United States
Exelixis Clinical Site #246

Rozzano, Milano, 20089, Italy
Exelixis Clinical Site #247

Viña del Mar, Región de Valparaíso, 2520598, Chile
Exelixis Clinical Site #248

Madrid, 28040, Spain
Exelixis Clinical Site #249

Blackburn, Lancashire, BB2 3HH, United Kingdom
Exelixis Clinical Site #25

Seoul, 06273, South Korea
Exelixis Clinical Site #250

San Luis Potosí City, San Luis Potosí, 78200, Mexico
Exelixis Clinical Site #251

Madrid, 28046, Spain
Exelixis Clinical Site #252

Port Macquarie, New South Wales, 2444, Australia
Exelixis Clinical Site #253

Chermside, Queensland, 4032, Australia
Exelixis Clinical Site #254

León, Guanajuato, 37178, Mexico
Exelixis Clinical Site #255

Barcelona, 08036, Spain
Exelixis Clinical Site #256

Caba, C1120AAT, Argentina
Exelixis Clinical Site #257

Monterrey, Nuevo León, 64710, Mexico
Exelixis Clinical Site #258

Milan, 20133, Italy
Exelixis Clinical Site #259

Houston, Texas, 77030, United States
Exelixis Clinical Site #26

Nagano, 381-8551, Japan
Exelixis Clinical Site #27

Jerusalem, 9112001, Israel
Exelixis Clinical Site #271

Tainan, 710, Taiwan
Exelixis Clinical Site #272

Puebla City, 72530, Mexico
Exelixis Clinical Site #273

Hanover, 30625, Germany
Exelixis Clinical Site #274

Badalona, 08916, Spain
Exelixis Clinical Site #28

Lugo, 27003, Spain
Exelixis Clinical Site #29

Seville, 41009, Spain
Exelixis Clinical Site #3

Marina del Rey, California, 90292, United States
Exelixis Clinical Site #30

Safed, 1311001, Israel
Exelixis Clinical Site #31

Prague, 140 59, Czechia
Exelixis Clinical Site #32

Wakayama, 641-8510, Japan
Exelixis Clinical Site #33

Córdoba, 14004, Spain
Exelixis Clinical Site #34

Hwasun, Jeollanam-do, 58128, South Korea
Exelixis Clinical Site #35

Tel Aviv, 6423906, Israel
Exelixis Clinical Site #36

Strasbourg, 67200, France
Exelixis Clinical Site #37

Sapporo, Hokkaido, 060-8648, Japan
Exelixis Clinical Site #38

Paris, 75015, France
Exelixis Clinical Site #39

Ghent, Oost-Vlaanderen, 9000, Belgium
Exelixis Clinical Site #4

Tucson, Arizona, 85741, United States
Exelixis Clinical Site #40

Gwangju, 61469, South Korea
Exelixis Clinical Site #41

Temple, Texas, 76504, United States
Exelixis Clinical Site #42

Duarte, California, 91010, United States
Exelixis Clinical Site #43

Kashiwa-shi, Chiba, 277-8577, Japan
Exelixis Clinical Site #44

Ciudad Autonoma de Buenos Aire, C1012AAR, Argentina
Exelixis Clinical Site #45

Heraklion, Crete, 71110, Greece
Exelixis Clinical Site #46

Seoul, 03722, South Korea
Exelixis Clinical Site #47

Prague, 180 81, Czechia
Exelixis Clinical Site #48

Seoul, 06351, South Korea
Exelixis Clinical Site #49

Goyang-si, Gyeonggi-do, 10408, South Korea
Exelixis Clinical Site #5

Houston, Texas, 77027, United States
Exelixis Clinical Site #50

Singapore, 169610, Singapore
Exelixis Clinical Site #51

Hidaka, Saitama, 350-1298, Japan
Exelixis Clinical Site #52

Kobe, Hyōgo, 650-0047, Japan
Exelixis Clinical Site #53

Melbourne, Victoria, 3000, Australia
Exelixis Clinical Site #54

Sakura-shi, Chiba, 285-8741, Japan
Exelixis Clinical Site #55

Haifa, 3109601, Israel
Exelixis Clinical Site #56

Porto, 4099-001, Portugal
Exelixis Clinical Site #57

Budapest, 1122, Hungary
Exelixis Clinical Site #58

Busan, 47392, South Korea
Exelixis Clinical Site #59

Seoul, 03080, South Korea
Exelixis Clinical Site #6

Baltimore, Maryland, 21204, United States
Exelixis Clinical Site #60

Seongnam-si, Gyeonggi-do, 13620, South Korea
Exelixis Clinical Site #61

Ube, Yamaguchi, 755-8505, Japan
Exelixis Clinical Site #62

Roma, 00144, Italy
Exelixis Clinical Site #63

Prague, Prague, 120 00, Czechia
Exelixis Clinical Site #64

Thessaloniki, Macedonia, 54007, Greece
Exelixis Clinical Site #65

Shinjuku-Ku, Tokyo, 160-8582, Japan
Exelixis Clinical Site #66

Quimper, 29107, France
Exelixis Clinical Site #67

Salt Lake City, Utah, 84112, United States
Exelixis Clinical Site #68

Sagamihara, Kanagawa, 252-0375, Japan
Exelixis Clinical Site #69

Edmonton, Alberta, T6G 1Z2, Canada
Exelixis Clinical Site #7

Oakville, Ontario, L6H 3PI, Canada
Exelixis Clinical Site #70

Kobe, Hyōgo, 650-0017, Japan
Exelixis Clinical Site #71

Lutsk, 43018, Ukraine
Exelixis Clinical Site #72

Sapporo, Hokkaido, 060-8543, Japan
Exelixis Clinical Site #73

Toulouse, 31059, France
Exelixis Clinical Site #74

Hyères, 83400, France
Exelixis Clinical Site #75

Tokyo, 135-8550, Japan
Exelixis Clinical Site #76

Kyiv, 02125, Ukraine
Exelixis Clinical Site #77

Clermont-Ferrand, 63011, France
Exelixis Clinical Site #78

Chiba, 260-8717, Japan
Exelixis Clinical Site #79

Ballarat, Victoria, 3350, Australia
Exelixis Clinical Site #8

Tbilisi, 0186, Georgia
Exelixis Clinical Site #80

Prague, 128 00, Czechia
Exelixis Clinical Site #81

Ōsaka-sayama, 589-8511, Japan
Exelixis Clinical Site #82

Bydgoszcz, 85-796, Poland
Exelixis Clinical Site #83

Hamilton, Ontario, L8V 5C2, Canada
Exelixis Clinical Site #84

Kita-gun, Kagawa-ken, 761-0793, Japan
Exelixis Clinical Site #85

Toulouse, 31076, France
Exelixis Clinical Site #86

Taichung, 404, Taiwan
Exelixis Clinical Site #87

Singapore, 258499, Singapore
Exelixis Clinical Site #88

Chūōku, Osaka-shi, 541-8567, Japan
Exelixis Clinical Site #89

Poznan, 60-569, Poland
Exelixis Clinical Site #9

Tbilisi, 0141, Georgia
Exelixis Clinical Site #90

Santiago, 7500653, Chile
Exelixis Clinical Site #91

Aurora, Colorado, 80045, United States
Exelixis Clinical Site #92

Marousi, Attica, 15125, Greece
Exelixis Clinical Site #93

Cholargós, Attica, 15562, Greece
Exelixis Clinical Site #94

Daegu, 41404, South Korea
Exelixis Clinical Site #95

Frankston, Victoria, 3199, Australia
Exelixis Clinical Site #96

Terni, 05100, Italy
Exelixis Clinical Site #97

Larissa, Thessaly, 41110, Greece
Exelixis Clinical Site #98

Gütersloh, North Rhine-Westphalia, 33332, Germany
Exelixis Clinical Site #99

Neo Faliro, Attica, 18547, Greece
Exelixis Clinical Stie #260

Saint Albans, Victoria, 3021, Australia
Exelixis Site #156

Sondrio, SO, 23100, Italy
Exelixis Site #157

Porto Alegre, Rio Grande do Sul, 90610-00, Brazil
Exelixis Site #158

Linz, Upper Austria, 4020, Austria
Exelixis Site #159

Cleveland, Ohio, 44195, United States
Exelixis Site #160

Montreal, Quebec, H2X 3E4, Canada
Exelixis Site #161

São Paulo, São Paulo, 04538-132, Brazil
Exelixis Site #162

Wollongong, New South Wales, 2500, Australia
Exelixis Site #163

Curitiba, Paraná, 80510-130, Brazil
Exelixis Site #164

Lisbon, 1400-038, Portugal
Exelixis Site #165

Roeselare, 8800, Belgium
Exelixis Site #166

Moscow, 115478, Russia
Exelixis Site #168

Meldola, FC, 47014, Italy
Exelixis Site #170

Pergamino, Buenos Aires, B2700CPM, Argentina
Exelixis site #167

Gyula, 5700, Hungary
Non-participating Site

Detroit, Michigan, 48202, United States
Non-participating Site

Lawrenceville, New Jersey, 08648, United States
Weill Cornell Medical College

New York, New York, 10065, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States
Yale University School of Medicine

New Haven, Connecticut, 06520, United States
Yale University, School of Medicine

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC PROSTATE CANCER PROSTATE ADENOCARCINOMA