New hope for vulnerable prostate cancer patients: drug combo aims to delay disease worsening

NCT ID NCT04916613

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen May 01, 2026 · Last updated May 14, 2026 · Updated 4 times

Summary

This study tests whether adding darolutamide to standard hormone therapy (ADT) can slow cancer growth in men with metastatic prostate cancer who are not healthy enough for stronger treatments like chemotherapy. About 300 participants will receive either the drug combination or a placebo. The goal is to see if the combination delays cancer progression and improves outcomes for this vulnerable group.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Contact

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Locations

APHP - Hôpital Henri Mondor
RECRUITING

Créteil, 94010, France

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Albert Schweizer Hospital
NOT_YET_RECRUITING

Dordrecht, Netherlands

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Althaia, Xara Assistencial Universitaria Mansera
RECRUITING

Manresa, Spain

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Amethyst Radiotherapy Center Cluj SRL
NOT_YET_RECRUITING

Cluj-Napoca, Romania

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Azienda Ospedaliera Universitaria Policlinico Riuniti Di Foggia
RECRUITING

Foggia, Italy

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CH Annecy Genevois
RECRUITING

Pringy, 74374, France

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CH Colmar
RECRUITING

Colmar, France

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CH Mont De Marsan
RECRUITING

Mont-de-Marsan, 40024, France

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CHIC Quimper
RECRUITING

Quimper, 29107, France

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CHP Centre Saint Grégoire
RECRUITING

Saint-Grégoire, 35760, France

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CHRU de Tours -Hôpital Bretonneau
RECRUITING

Tours, 37044, France

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CHU Besançon - Hopital Jean Mijoz
RECRUITING

Besançon, 25000, France

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CHU Grenoble
RECRUITING

Grenoble, 38043, France

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CHU Nîmes
RECRUITING

Nîmes, 30029, France

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CHU Saint-Etienne
RECRUITING

Saint-Etienne, 42055, France

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CHU Sud Réunion
NOT_YET_RECRUITING

La Réunion, 97448, France

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CHU UCL NAMUR - Site STE. ELISABETH
RECRUITING

Namur, 5000, Belgium

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CHU de Poitiers - Pôle Régional de Cancérologie
RECRUITING

Poitiers, 86021, France

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CHU de la Martinique - Hôpital Albert Clarac
NOT_YET_RECRUITING

Fort-de-France, 97200, Martinique

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CHU le MANS
RECRUITING

Le Mans, 72000, France

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Cantonal Hospital St.Gallen
RECRUITING

Sankt Gallen, Switzerland

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Centre Antoine Lacassagne
RECRUITING

Nice, 06189, France

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Centre Azuréen de Cancérologie
RECRUITING

Mougins, 06250, France

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Centre CHV Vendée
RECRUITING

La Roche-sur-Yon, 85925, France

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Centre Eugène Marquis
RECRUITING

Rennes, 35042, France

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Centre Eugène Marquis - Rennes
RECRUITING

Rennes, France

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Centre François Baclesse
RECRUITING

Caen, 14076, France

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Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France

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Centre Groupe Hospitalier Diaconesses Croix Saint-Simon
RECRUITING

Paris, 75020, France

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Centre Hospitalier Cote basque
RECRUITING

Bayonne, 64109, France

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Centre Hospitalier Intercommunal de Toulon-La Seyne - Hôpital Ste Musse
RECRUITING

Toulon, 83056, France

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Centre Hospitalier Métropole Savoie
RECRUITING

Chambéry, 73000, France

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Centre Hospitalier Rodez
RECRUITING

Rodez, 12027, France

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Centre Institut Bergonié
RECRUITING

Bordeaux, 22076, France

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Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France

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Centre Léon Bérard
RECRUITING

Lyon, 69373, France

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Centre Oscar Lambret
RECRUITING

Lille, 59000, France

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Centre Pierre Curie
RECRUITING

Beuvry, 62660, France

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Centro Integral Oncologico HM Clara Campal
RECRUITING

Madrid, Spain

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Clinique Pasteur
RECRUITING

Brest, 29200, France

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Clinique Pasteur ONCORAD
RECRUITING

Toulouse, 31076, France

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Clinique Saint Pierre
RECRUITING

Ottignies, 1340, Belgium

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Clinique Sainte Anne - Strasbourg Oncologie Libérale
RECRUITING

Strasbourg, 67000, France

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FPO IRCCS Candiolo Turin
RECRUITING

Candiolo, Italy

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Fondazione IRCSS Istituto Nazionale Tumori
RECRUITING

Milan, 20133, Italy

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
SUSPENDED

Roma, 00168, Italy
Fundacion Instituto Valenciano De Oncologia
RECRUITING

Valencia, Spain

Contact Email: •••••@•••••
Grand Hopital de Charleroi - site Notre Dame
RECRUITING

Charleroi, 6000, Belgium

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Groupe Hospitalier Bretagne Sud
RECRUITING

Lorient, 56322, France

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Groupe Jolimont - Hôpital De Jolimont
RECRUITING

Haine-Saint-Paul, 7100, Belgium

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Gustave Roussy Center
RECRUITING

Villejuif, 94805, France

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Hospices Civils de Lyon -Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France

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Hospital Clinic
RECRUITING

Barcelona, Spain

Contact Email: •••••@•••••
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain

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Hospital del Mar
RECRUITING

Barcelona, Spain

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Hôpital Européen Georges Pompidou
RECRUITING

Paris, 75908, France

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Hôpital FOCH
RECRUITING

Suresnes, 92151, France

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Hôpital Instruction des Armées - BEGIN
RECRUITING

Saint-Mandé, 94160, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hôpital Privé de la Loire
RECRUITING

Saint-Etienne, 42100, France

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Hôpital Saint Louis
RECRUITING

Paris, 75475, France

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Hôpital Tenon
RECRUITING

Paris, 75970, France

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Hôpitaux Universitaires de Strasbourg
RECRUITING

Strasbourg, 67200, France

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IRCCS Ospedale San Raffaele
RECRUITING

Milan, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
IUCT Oncopole
RECRUITING

Toulouse, 31059, France

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Institul Oncologic Cluj-Napoca
RECRUITING

Cluj-Napoca, Romania

Contact Email: •••••@•••••
Institut Catala d'Oncologia, Badalona-Hospital Germans Trias i Pujol
RECRUITING

Badalona, Spain

Contact Email: •••••@•••••
Institut Català d'Oncologia de Girona
RECRUITING

Girona, Spain

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Institut Jean Godinot
RECRUITING

Reims, 51056, France

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Institut Paoli-Calmettes
RECRUITING

Marseille, 13273, France

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Institut Sainte Catherine
RECRUITING

Avignon, 84918, France

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Institut de Cancérologie de Lorraine
RECRUITING

Vandœuvre-lès-Nancy, 54500, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
Institutul Oncologic Prof Dr Al Trestioreanu Bucuresti
NOT_YET_RECRUITING

Bucharest, Romania

Contact Email: •••••@•••••
Istituto Clinico Humanitas - IRCCS
RECRUITING

Rozzano, 20089, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
Istituto Oncologico della Svizzera Italiana (IOSI) - Ospedale Italiano di Lugano
RECRUITING

Viganello, Switzerland

Contact Email: •••••@•••••
Istituto Oncologico della Svizzera Italiana (IOSI) - Ospedale S.Giovanni
RECRUITING

Bellinzona, 6500, Switzerland

Contact Phone: •••-•••-•••• Email: •••••@•••••
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.)
RECRUITING

Meldola, 47014, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kantonsspital Graubünden, Onkologie/ Hämatologie
RECRUITING

Chur, Switzerland

Contact Email: •••••@•••••
Mater Misericordiae University Hospital
RECRUITING

Dublin, Ireland

Contact Email: •••••@•••••
Mater Private Hospital
RECRUITING

Dublin, Ireland

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Narodny Onkologicky Institut
RECRUITING

Bratislava, Slovakia

Contact Email: •••••@•••••
OncoHelp Hospital
RECRUITING

Timișoara, Romania

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Polyclinique de Limoges
RECRUITING

Limoges, 87000, France

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Radboudumc - Dutch Uro-Oncology Study Group (DUOS)
RECRUITING

Nijmegen, Netherlands

Contact Email: •••••@•••••
Sahlgrenska University Hospital
RECRUITING

Gothenburg, Sweden

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Santa Chiara Hospital
RECRUITING

Trento, 38122, Italy

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Skane University Hospital
RECRUITING

Malmö, Sweden

Contact Email: •••••@•••••
St Vincent's University Hospital
RECRUITING

Dublin, D04 T6F4, Ireland

Contact Email: •••••@•••••
Tallaght university Hospital
RECRUITING

Dublin, D24 NR0A, Ireland

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UOC Oncologia Medica
RECRUITING

Syracuse, 96100, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••
University Hospital Limerick
RECRUITING

Limerick, Ireland

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University of Bari, Policlinico
SUSPENDED

Bari, 70124, Italy
Universitätsmedizin Essen Hufelandstraße
SUSPENDED

Essen, Germany
Universitätsspital Zürich - Onkologie
RECRUITING

Zurich, Switzerland

Contact Email: •••••@•••••
Vall d'Hebron Institute of Oncology. Vall d'Hebron University Hospital
RECRUITING

Barcelona, Spain

Contact Email: •••••@•••••
istituto tumori Fondazione "G.Pascale"
RECRUITING

Naples, 80131, Italy

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

PROSTATE CANCER METASTATIC