New drug shows promise in slowing deadly prostate cancer spread

NCT ID NCT01946204

Ongoing Disease control Sponsor: Aragon Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 trial tested whether the drug apalutamide (ARN-509) could delay the spread of prostate cancer in men whose cancer had stopped responding to standard hormone therapy but hadn't yet spread to other body parts. About 1,200 men were randomly assigned to receive either the study drug or a placebo pill, along with their ongoing hormone treatment. The main goal was to see if the drug could help men live longer without their cancer spreading to bones or other organs.

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Contacts and locations

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Locations

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Birmingham, Alabama, United States
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Anchorage, Alaska, United States
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Chandler, Arizona, United States
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Tucson, Arizona, United States
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Duarte, California, United States
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Fullerton, California, United States
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Laguna Woods, California, United States
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Los Angeles, California, United States
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Orange, California, United States
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Roseville, California, United States
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Sacramento, California, United States
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San Bernardino, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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Santa Monica, California, United States
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Sherman Oaks, California, United States
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Stanford, California, United States
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Tarzana, California, United States
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Torrance, California, United States
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Denver, Colorado, United States
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Englewood, Colorado, United States
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Glenwood Springs, Colorado, United States
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Grand Junction, Colorado, United States
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Washington D.C., District of Columbia, United States
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Aventura, Florida, United States
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Boca Raton, Florida, United States
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Bradenton, Florida, United States
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Daytona Beach, Florida, United States
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Fort Myers, Florida, United States
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Hialeah, Florida, United States
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Jacksonville, Florida, United States
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Miami, Florida, United States
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New Port Richey, Florida, United States
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Orlando, Florida, United States
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Sarasota, Florida, United States
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St. Petersburg, Florida, United States
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Wellington, Florida, United States
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Meridian, Idaho, United States
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Chicago, Illinois, United States
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Decatur, Illinois, United States
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Maywood, Illinois, United States
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Melrose Park, Illinois, United States
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Carmel, Indiana, United States
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Jeffersonville, Indiana, United States
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Muncie, Indiana, United States
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West Des Moines, Iowa, United States
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Westwood, Kansas, United States
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Wichita, Kansas, United States
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Metairie, Louisiana, United States
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New Orleans, Louisiana, United States
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Annapolis, Maryland, United States
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Baltimore, Maryland, United States
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Rockville, Maryland, United States
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Towson, Maryland, United States
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Boston, Massachusetts, United States
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Detroit, Michigan, United States
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Lansing, Michigan, United States
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Minneapolis, Michigan, United States
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Royal Oak, Michigan, United States
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Duluth, Minnesota, United States
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Bay Saint Louis, Mississippi, United States
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Southaven, Mississippi, United States
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Kansas City, Missouri, United States
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Missoula, Montana, United States
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Omaha, Nebraska, United States
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Las Vegas, Nevada, United States
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Hooksett, New Hampshire, United States
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Hackensack, New Jersey, United States
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Lawrenceville, New Jersey, United States
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Morristown, New Jersey, United States
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Mount Laurel, New Jersey, United States
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New Brunswick, New Jersey, United States
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Voorhees Township, New Jersey, United States
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Albuquerque, New Mexico, United States
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Albany, New York, United States
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Mineola, New York, United States
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New York, New York, United States
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Oneida, New York, United States
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Poughkeepsie, New York, United States
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Syracuse, New York, United States
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The Bronx, New York, United States
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Concord, North Carolina, United States
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Greensboro, North Carolina, United States
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Greenville, North Carolina, United States
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Salisbury, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Cincinnati, Ohio, United States
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Cleveland, Ohio, United States
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Middleburg Heights, Ohio, United States
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Middletown, Ohio, United States
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Bend, Oregon, United States
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Portland, Oregon, United States
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Tualatin, Oregon, United States
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Bala-Cynwyd, Pennsylvania, United States
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Bryn Mawr, Pennsylvania, United States
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Lancaster, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Warwick, Rhode Island, United States
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Charleston, South Carolina, United States
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Greenville, South Carolina, United States
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Myrtle Beach, South Carolina, United States
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West Columbia, South Carolina, United States
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Memphis, Tennessee, United States
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Nashville, Tennessee, United States
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Abilene, Texas, United States
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Amarillo, Texas, United States
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Dallas, Texas, United States
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Fort Sam Houston, Texas, United States
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Houston, Texas, United States
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McAllen, Texas, United States
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San Antonio, Texas, United States
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Norfolk, Virginia, United States
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Richmond, Virginia, United States
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Virginia Beach, Virginia, United States
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Burien, Washington, United States
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Edmonds, Washington, United States
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Seattle, Washington, United States
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Tacoma, Washington, United States
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Green Bay, Wisconsin, United States
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Madison, Wisconsin, United States
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Milwaukee, Wisconsin, United States
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Adelaide, Australia
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Box Hill, Australia
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Camperdown, Australia
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Darlinghurst, Australia
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Geelong, Australia
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Gosford, Australia
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Hobart, Australia
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Kogarah, Australia
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Liverpool, Australia
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Melbourne, Australia
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Nedlands, Australia
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Parkville, Australia
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South Woodville, Australia
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Southport, Australia
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Sydney, Australia
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Tweed Heads, Australia
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Wollongong, Australia
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Vienna, Austria
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Brussels, Belgium
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Ghent, Belgium
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Kortrijk, Belgium
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Leuven, Belgium
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Liège, Belgium
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Ottignies, Belgium
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Abbotsford, British Columbia, Canada
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Kelowna, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Victoria, British Columbia, Canada
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Moncton, New Brunswick, Canada
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Saint John, New Brunswick, Canada
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Halifax, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Brampton, Ontario, Canada
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Brantford, Ontario, Canada
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Hamilton, Ontario, Canada
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London, Ontario, Canada
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North York, Ontario, Canada
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Oakville, Ontario, Canada
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Ottawa, Ontario, Canada
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Owen Sound, Ontario, Canada
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Toronto, Ontario, Canada
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Gatineau, Quebec, Canada
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Granby, Quebec, Canada
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Greenfield Park, Quebec, Canada
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Laval, Quebec, Canada
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Montreal, Quebec, Canada
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Pointe-Claire, Quebec, Canada
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Québec, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Liberec, Czechia
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Olomouc, Czechia
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Opava, Czechia
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Pilsen, Czechia
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Prague, Czechia
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Aalborg C, Denmark
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Copenhagen, Denmark
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Odense, Denmark
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Roskilde, Denmark
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Helsinki, Finland
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Oulu, Finland
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Seinäjoki, Finland
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Tampere, Finland
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Turku, Finland
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Angers, France
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Besançon, France
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Bordeaux, France
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Caen Cédex 05, France
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Clermont-Ferrand, France
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Hyers, France
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La Roche-sur-Yon, France
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Le Mans, France
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Lille Cedex N/a, France
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Lyon, France
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Marseille, France
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Nice, France
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Nîmes, France
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Paris, France
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Reims, France
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Rennes, France
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Rouen, France
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Saint-Grégoire, France
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Saint-Herblain, France
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Strasbourg, France
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Suresnes, France
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Tours, France
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Vandœuvre-lès-Nancy, France
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Aachen, Germany
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Bergisch Gladbach, Germany
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Berlin, Germany
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Braunschweig, Germany
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Cologne, Germany
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Duisburg, Germany
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Emmendingen, Germany
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Frankfurt am Main, Germany
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Göttingen, Germany
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Greifswald, Germany
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Hamburg, Germany
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Hanover, Germany
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Heidelberg, Germany
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Heinsberg, Germany
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Homburg/Saar, Germany
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Jena, Germany
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Kiel, Germany
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Kirchheim unter Teck, Germany
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Magdeburg, Germany
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Mainz, Germany
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Mannheim, Germany
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Marburg, Germany
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Mettmann, Germany
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Müllheim, Germany
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Münster, Germany
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Nürtingen, Germany
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Regensburg, Germany
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Rostock, Germany
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Tübingen, Germany
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Weiden, Germany
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Wilhelmshaven, Germany
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Wuppertan, Germany
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Zirndorf, Germany
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Budapest, Hungary
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Miskolc, Hungary
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Nyíregyhá, Hungary
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Sopron, Hungary
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Szentes, Hungary
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Haifa, Israel
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Jeruselem, Israel
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Kfar Saba, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Ẕerifin, Israel
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Akita, Japan
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Fukuoka, Japan
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Gifu, Japan
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Hakodate, Japan
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Hiroshima, Japan
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Hokkaido, Japan
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Kanazawa, Japan
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Kashiwa, Japan
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Kita-Gun, Japan
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Kobe, Japan
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Koshigaya, Japan
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Kumamoto, Japan
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Kurume, Japan
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Matsuyama, Japan
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Nagano, Japan
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Nagasaki, Japan
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Nagoya, Japan
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Niigata, Japan
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Osaka, Japan
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Ōsaka-sayama, Japan
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Sagamihara, Japan
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Sakura, Japan
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Sapporo, Japan
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Shinjuku-Ku, Japan
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Tokushima, Japan
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Tokyo, Japan
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Ube, Japan
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Wakayama, Japan
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Yokohama, Japan
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Alkmaar, Netherlands
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Eindhoven, Netherlands
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Hoofddorp, Netherlands
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Leidschendam, Netherlands
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Nijmegen, Netherlands
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Rotterdam, Netherlands
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Auckland, New Zealand
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Christchurch, New Zealand
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Hamilton, New Zealand
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Nelson, New Zealand
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Tauranga, New Zealand
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Whangarei, New Zealand
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Nordbyhagen, Norway
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Bialystok, Poland
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Bydgoszcz, Poland
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Gdansk, Poland
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Kutno, Poland
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Lodz, Poland
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Poznan, Poland
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Szczecin, Poland
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Torun, Poland
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Warsaw, Poland
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Wroclaw, Poland
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Baia Mare, Romania
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Brasov, Romania
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Bucharest, Romania
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Cluj-Napoca, Romania
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Târgu Mureş, Romania
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Barnaul, Russia
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Ivanovo, Russia
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Moscow, Russia
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Obninsk, Russia
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Omsk, Russia
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Ryazan, Russia
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Saint Petersburg, Russia
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Ufa, Russia
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Yaroslavl, Russia
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Yekaterinburg, Russia
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Banská Bystrica, Slovakia
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Bratislava, Slovakia
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Martin, Slovakia
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Nitra, Slovakia
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Trenčín, Slovakia
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Daegu, South Korea
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Gwangju, South Korea
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Pusan, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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A Coruña, Spain
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Badalona, Spain
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Barcelona, Spain
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Castellon, Spain
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Girona, Spain
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Guadalajara, Spain
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Jerez de la Frontera, Spain
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Las Palmas de Gran Canaria, Spain
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Madrid, Spain
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Málaga, Spain
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Murcia, Spain
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Palma de Mallorca, Spain
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Pamplona, Spain
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Sabadell, Spain
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Salamanca, Spain
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San Sebastián de los Reyes, Spain
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Santander, Spain
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Seville, Spain
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Valencia, Spain
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Gothenburg, Sweden
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Örebro, Sweden
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Stockholm, Sweden
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Umeå, Sweden
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Uppsala, Sweden
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Blackburn, United Kingdom
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Cambridge, United Kingdom
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Cardiff, United Kingdom
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Dundee, United Kingdom
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Glasgow, United Kingdom
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Guildford, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Maidstone, United Kingdom
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Metropolitan Borough of Wirral, United Kingdom
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Nottingham, United Kingdom
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Plymouth, United Kingdom
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Southampton, United Kingdom
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Surrey, United Kingdom
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Swansea, United Kingdom
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Wolverhampton, United Kingdom

Conditions

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PROSTATIC NEOPLASMS