Could gut bacteria help fight prostate cancer? new trial tests antibiotic combo
NCT ID NCT06126731
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This trial tests whether a short course of four antibiotics can make the standard drug enzalutamide work better in men with metastatic castration-resistant prostate cancer. About 39 men will receive the antibiotics plus enzalutamide to see if the combination is safe and can shrink tumors or lower PSA levels. The goal is to improve disease control in this advanced stage of cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Amoxicillin, metronidazole, ciprofloxacin, vancomycin, and enzalutamide
What this could lead to
If it works, this could point toward a way to make enzalutamide more effective for men with advanced prostate cancer by targeting gut bacteria.
What could go wrong
This is an early, small trial (39 people) testing safety and effectiveness. The antibiotic combination may cause side effects or not improve outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Oncolgy Institute of Southern Switzerland (IOSI)
RECRUITINGBellinzona, Switzerland
Contact Email: •••••@•••••
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The Royal Marsden NHS Foundation Trust
RECRUITINGSutton, SM2 5PT, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••