New donor cartilage implant aims to fix knee damage in one surgery

NCT ID NCT03873545

Ongoing Disease control Sponsor: AlloSource Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a special donor tissue called ProChondrix CR to repair damaged knee cartilage in 34 adults aged 18 to 60. The tissue is implanted during surgery to help reduce pain and improve knee function over 5 years. Researchers will track changes in pain, movement, and quality of life to see if this single-step approach works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ProChondrix CR (cryopreserved donor cartilage and bone tissue)
What this could lead to: If it works, this could provide a single-step surgical option to repair knee cartilage damage, reducing pain and improving mobility without needing multiple procedures.
What could go wrong: This is a small, early-stage study with only 34 participants, so results may not apply to everyone. The implant may fail to integrate or symptoms may not improve significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARTILAGE DAMAGE CARTILAGE INJURY

Contacts and locations

Locations

Beacon Orthopaedics & Sports Medicine

Cincinnati, Ohio, 45247, United States
Midwest Orthopaedics at Rush

Chicago, Illinois, 60612, United States
University of Kentucky Research Foundation

Lexington, Kentucky, 40506, United States

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