Could a daily probiotic boost sperm health in men over 40?
NCT ID NCT06544278
First seen Aug 03, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This trial tests whether a daily probiotic supplement containing Bifidobacterium longum BL21 can improve sperm quality in men aged 40 to 59. Over 8 weeks, participants take either the probiotic or a placebo, and researchers measure changes in sperm motility, hormone levels, and other markers. The goal is to see if this simple supplement could support male fertility in middle age.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- probiotic product containing Bifidobacterium longum subsp. longum BL21
- What this could lead to
- If effective, this probiotic could offer a simple, non-prescription option to support sperm health in middle-aged men.
- What could go wrong
- This is a small, early-stage trial with only 40 participants, so results may not apply broadly. Probiotics are generally safe, but individual responses can vary.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Qilu Hospital of Shangdong University
Jinan, Shangdong, 250012, China
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