Probiotics may reshape newborn gut health after C-Section or antibiotics
NCT ID NCT04304014
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether giving specific probiotics to healthy newborns can help restore a balanced gut microbiome after a dysbiotic delivery — birth by C-section or after maternal antibiotics. Around 120 infants will receive either L. reuteri or a mix of B. longum and P. pentosaceus daily for one month. Researchers will measure changes in beneficial gut bacteria and track digestive symptoms like spit-ups and constipation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- two different probiotic supplements: L. reuteri or a combination of B. longum and P. pentosaceus
- What this could lead to
- If successful, this could point toward a simple probiotic strategy to support healthy gut bacteria in babies born by C-section or after maternal antibiotics.
- What could go wrong
- This is a small, early-stage trial with only 120 infants, and it focuses on gut bacteria levels rather than health outcomes. The benefits may not translate to fewer symptoms or long-term effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fundación HM Hospitales (Hospital HM Puerta Sur)
Madrid, Madrid, 28938, Spain
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Hospital Universitari General de Catalunya
Sant Cugat del Vallès, Barcelona, 08195, Spain
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Neonatal Unit, Hospital Clinic-Maternitat
Barcelona, Spain
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