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Gut bacteria vs. spinal arthritis: can a probiotic calm inflammation?

NCT ID NCT07834788

Symptom relief Sponsor: Acibadem University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 22, 2026 · Last updated Sep 23, 2026 · Updated 1 time

Summary

Researchers are testing whether a daily probiotic, Lacticaseibacillus rhamnosus GG, can reduce disease activity and inflammation in adults with active ankylosing spondylitis. Thirty-one participants take either the probiotic or a placebo capsule for eight weeks while continuing their usual arthritis medication. The study measures changes in disease activity, physical function, and blood markers of inflammation called CRP and ESR.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lacticaseibacillus rhamnosus GG, a probiotic bacterium
What this could lead to
If the probiotic helps, it could offer a low-cost, low-risk add-on for people whose ankylosing spondylitis remains active despite standard treatment.
What could go wrong
This is a small, short study of 31 people, and gut bacteria may not influence spinal inflammation enough to change symptoms. Probiotics can cause mild digestive upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Oct 2018

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adults aged 25-65 years Physician-established diagnosis of ankylosing spondylitis Active-phase disease at screening, defined by all of the following: BASDAI \> 3 BASFI \> 3 C-reactive protein (CRP) \> 5 mg/L Erythrocyte sedimentation rate (ESR) \> 15 mm/h Exclusion Criteria: Use of any prebiotic, probiotic, or synbiotic product within the preceding 3 months Pregnancy or lactation Presence of any other chronic disease

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankylosing spondylitis

Contacts and locations

Locations

  • Çukurova University Balcalı Hospital

    Adana, Balcalı, 01330, Turkey (Türkiye)

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