New hope for Hard-to-Treat cancers: first human trial of BGB-58067 begins

NCT ID NCT06589596

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 5 times

Summary

This early-stage trial is testing a new drug called BGB-58067, alone or with other cancer treatments, in people with advanced solid tumors that have a specific genetic change (MTAP deficiency). The study aims to find the safest dose and see if the drug can shrink tumors. About 525 participants will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BGB-58067 (a PRMT5 inhibitor drug)
What this could lead to: If successful, this could lead to a new treatment option for people with advanced solid tumors that have a specific genetic marker (MTAP deficiency).
What could go wrong: This is a very early (Phase 1) trial, so the drug may not work or may cause unexpected side effects. It is also only for people with a specific tumor type, so results may not apply to all cancers.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Adventhealth
RECRUITING

Celebration, Florida, 34747-4606, United States
Asan Medical Center
RECRUITING

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Austin Health
RECRUITING

Heidelberg, Victoria, VIC 3084, Australia
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beijing Chest Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 101149, China
Blacktown Cancer and Haematology Centre
RECRUITING

Blacktown, New South Wales, NSW 2148, Australia
Cancer Hospital Chinese Academy of Medical Sciences
RECRUITING

Beijing, Beijing Municipality, 100021, China
Centre de Lutte Contre Le Cancer Institut Bergonie
RECRUITING

Bordeaux, 33000, France
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
RECRUITING

Porto Alegre, 90110-270, Brazil
Chongqing University Cancer Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215-5418, United States
Deyangs People Hospital
RECRUITING

Deyang, Sichuan, 618000, China
Ensino E Terapia de Inovacao Clinica Amo Etica
RECRUITING

Salvador, 41950-640, Brazil
Fudan University Shanghai Cancer Centerpudong
RECRUITING

Shanghai, Shanghai Municipality, 201321, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Fundacao Pio Xii Hospital de Amor de Barretos
RECRUITING

Barretos, 14.784-400, Brazil
Fundacao Universidade de Caxias Do Sul
RECRUITING

Caxias do Sul, 95070-560, Brazil
Guangxi Medical University Cancer Hospital Wuxiang Branch
RECRUITING

Nanning, Guangxi, 530201, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150000, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, 450000, China
Hospital Clinico San Carlos
RECRUITING

Madrid, 28240, Spain
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Pulau Pinang
RECRUITING

George Town, 10990, Malaysia
Hospital Raja Perempuan Zainab Ii
RECRUITING

Johor Bahru, 15586, Malaysia
Hospital Sao Lucas Da Pucrs
RECRUITING

Porto Alegre, 90610-000, Brazil
Hospital Universitario Hm Madrid Sanchinarro
RECRUITING

Madrid, 28050, Spain
Hospital Universitario Vall Dhebron
RECRUITING

Barcelona, 08035, Spain
Huashan Hospital Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Hubei Cancer Hospital
RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira
RECRUITING

São Paulo, 01246-000, Brazil
Institut Curie Paris
RECRUITING

Paris, 75005, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13009, France
Institut de Cancerologie de Louest
RECRUITING

Saint-Herblain, 44800, France
Jiangsu Province Hospital
RECRUITING

Nanjing, Jiangsu, 210029, China
Jiangxi Cancer Hospital
RECRUITING

Nanchang, Jiangxi, 330029, China
Jinan Central Hospital
RECRUITING

Jinan, Shandong, 250013, China
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, WA 6009, Australia
Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University)
RECRUITING

Muang, 50200, Thailand
Meizhou People Hospital
RECRUITING

Meizhou, Guangdong, 514031, China
Monash Health
RECRUITING

Clayton, Victoria, VIC 3168, Australia
Next Dallas
RECRUITING

Irving, Texas, 75039-2743, United States
Next Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Nucleo de Pesquisa E Ensino Da Rede Sao Camilo
RECRUITING

São Paulo, 04014-002, Brazil
Nyu Langone Health
RECRUITING

New York, New York, 10016-2708, United States
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, QLD 4102, Australia
Ramathibodi Hospital Mahidol University
RECRUITING

Bangkok, 10400, Thailand
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
Samsung Medical Center
RECRUITING

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Sarawak General Hospital
RECRUITING

Kuching, 93586, Malaysia
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Shanghai East Hospital Branch Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200123, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200433, China
Shanxi Provincial Cancer Hospital
RECRUITING

Taiyuan, Shanxi, 030013, China
Sichuan Cancer Hospital and Institute
RECRUITING

Chengdu, Sichuan, 610041, China
Sichuan Cancer Hospitaltianfu Branch
RECRUITING

Chengdu, Sichuan, 610000, China
Sidney Kimmel Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107-4307, United States
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING

São Paulo, 05652-900, Brazil
Songklanagarind Hospital (Prince of Songkhla University)
RECRUITING

Hat Yai, 90110, Thailand
Srinagarind Hospital (Khon Kaen University)
RECRUITING

Muang, 40002, Thailand
Start Madrid Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)
RECRUITING

Guangzhou, Guangdong, 510245, China
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
Taizhou Hospital of Zhejiang Provinceenze Branch
RECRUITING

Taizhou, Zhejiang, 318050, China
Tennessee Oncology, Pllc Nashville
RECRUITING

Nashville, Tennessee, 37203, United States
The Catholic University of Korea, St Vincents Hospital
RECRUITING

PaldalGu SuwonSi, Gyeonggi-do, 16247, South Korea
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
RECRUITING

Guangzhou, Guangdong, 510405, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The First Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, 110001, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130021, China
The Fourth Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050011, China
The Institute of Oncology, Arensia Exploratory Medicine
RECRUITING

Chisinau, 2025, Moldova
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital of Shandong First Medical University
RECRUITING

Taian, Shandong, 271099, China
The Second Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230601, China
The University of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4009, United States
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
Usc Norris Comprehensive Cancer Center (Nccc)
RECRUITING

Los Angeles, California, 90089-1019, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110-1010, United States
Weifang Peoples Hospital Beichen Branch
RECRUITING

Weifang, Shandong, 261057, China
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Yichang Central Peoples Hospital
RECRUITING

Yichang, Hubei, 443003, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, 310022, China
Zhejiang Provincial Peoples Hospital
RECRUITING

Hangzhou, Zhejiang, 310014, China

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