New cocktail of drugs and radiation takes on tough lung cancer
NCT ID NCT04728230
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 37 times
Summary
This study is testing a combination of drugs and radiation for people with extensive-stage small cell lung cancer (ES-SCLC) who haven't been treated yet. The drugs include olaparib (which blocks cancer cells from repairing themselves), durvalumab (which helps the immune system attack cancer), and standard chemotherapy. The goal is to see if this mix is safe and works better than current treatments. About 63 participants are involved in this early-phase trial.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Olaparib (PARP inhibitor), durvalumab (immunotherapy), carboplatin, etoposide, and radiation therapy
What this could lead to
If it works, this combination could offer a new, more effective treatment option for extensive-stage small cell lung cancer, potentially extending survival.
What could go wrong
This is an early-phase trial with only 63 participants, so results may not apply to everyone. Combining multiple treatments also raises the risk of serious side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.