Steroid shield: new hope to prevent HIV treatment complications

NCT ID NCT07565623

First seen May 05, 2026 · Last updated May 05, 2026

Summary

This study tests whether a short course of the steroid prednisolone can prevent a serious immune overreaction called IRIS in people with advanced HIV who are starting antiretroviral therapy. About 262 participants with low immune cell counts and active infections will be randomly assigned to receive either prednisolone or no extra treatment. The goal is to see if the steroid reduces the risk of IRIS over 12 weeks.

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