IPF patients: is combining drugs better than switching?

NCT ID NCT03939520

First seen Feb 17, 2026 · Last updated May 22, 2026 · Updated 16 times

Summary

This study looked at 279 people with idiopathic pulmonary fibrosis (IPF) whose disease was getting worse despite taking one of two approved drugs (pirfenidone or nintedanib). The goal was to see if combining both drugs works better than switching to the other drug alone. The trial measured lung function decline and how well patients tolerated the treatments over time.

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Contacts and locations

Locations

  • AP - HP - Hôpital Avicenne

    Bobigny, France

  • APHP - Hôpital Xavier Bichat-Claude Bernard

    Paris, France

  • CHRU Hôpital Cavale Blanche

    Brest, France

  • CHRU de Besançon - Hôpital Jean Minjoz

    Besançon, France

  • CHRU de Lille - Hôpital Albert Calmette

    Lille, France

  • CHRU de Montpellier - Hôpital Arnaud de Villeneuve

    Montpellier, France

  • CHRU, Tours - Hôpital Bretonneau

    Tours, France

  • CHU - Hôpital G.R. Laennec

    Nantes, France

  • CHU Dijon Bourgogne - Hôpital François Mitterrand

    Dijon, France

  • CHU Nancy - Hôpital Brabois

    Vandœuvre-lès-Nancy, France

  • CHU Poitiers

    Poitiers, 86021, France

  • CHU Rennes - Hôpital Pontchaillou

    Rennes, France

  • CHU d'Angers

    Angers, France

  • CHU de Caen - Hôpital de la Côte de Nacre

    Caen, France

  • CHU de Marseille - Hôpital Nord

    Marseille, France

  • CHU de Nice, Hôpital Pasteur

    Nice, France

  • CHU de Toulouse - Hôpital Larrey

    Toulouse, France

  • Centre Hospitalier de la côte Basque

    Bayonne, France

  • Ch de Cornouaille

    Quimper, France

  • Groupe Hospitalier Paris Saint Joseph

    Paris, France

  • Hôpital Pneumologique et Cardiovasculaire Louis Pradel

    Bron, France

  • Hôpital Robert Schuman

    Vantoux, France

Conditions

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