New drug shows promise for painful hand and foot pustules

NCT ID NCT03135548

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 26 times

Summary

This study tested a new medicine called BI 655130 in 59 adults with palmoplantar pustulosis (PPP), a skin condition causing painful pus-filled blisters on the palms and soles. The goal was to see if the drug safely reduces the severity of the pustules and plaques compared to a placebo. Results suggest the drug may help control the disease, but ongoing treatment is likely needed.

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Contacts and locations

Locations

  • Aarhus University Hospital, Skejby

    Aarhus, 8200, Denmark

  • Bispebjerg og Frederiksberg Hospital

    København NV, 2400, Denmark

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Dr. Irina Turchin PC Inc.

    Fredericton, New Brunswick, E3B 1G9, Canada

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Hospital Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Santa Creu i Sant Pau

    Barcelona, 08026, Spain

  • Hospital Universitario Infanta Leonor

    Madrid, 28031, Spain

  • Innovaderm Research Inc.

    Montreal, Quebec, H2K 4L5, Canada

  • Karolinska Univ. sjukhuset

    Stockholm, 171 76, Sweden

  • Ospedale San Giovanni di Dio

    Cagliari, 09124, Italy

  • Pol. Universitario Tor Vergata

    Roma, 00133, Italy

  • Sahlgrenska US, Göteborg

    Gothenburg, 413 45, Sweden

  • TFS Trial Form Support GmbH

    Hamburg, 20537, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt am Main, 60596, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105, Germany

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4C 9M7, Canada

Conditions

Explore the condition pages connected to this study.