New hope for rare lung cancer? poziotinib trial targets HER2 mutations
NCT ID NCT05378763
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 study compares the experimental drug poziotinib to the standard chemotherapy docetaxel in 268 people with advanced non-small cell lung cancer that has a specific HER2 mutation. Participants must have already tried at least one prior treatment. The main goal is to see if poziotinib can delay cancer growth longer than docetaxel. The trial is currently on hold.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
poziotinib
What this could lead to
If successful, poziotinib could offer a new targeted treatment option for people with a specific type of lung cancer that has few approved therapies.
What could go wrong
The trial is currently suspended, and it's a head-to-head comparison against an existing chemotherapy. Success is not guaranteed, and side effects from poziotinib may be significant.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NSCLC are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Bond Clinic, P.A.
Winter Haven, Florida, 33880, United States