Nose swab before leg surgery may slash infection risk

NCT ID NCT05763602

First seen Feb 04, 2026 · Last updated May 23, 2026 · Updated 8 times

Summary

This study looks at whether applying povidone iodine (a germ-killing solution) inside the nose before surgery can lower the chance of getting a serious infection after fixing severe leg, ankle, or foot fractures. About 2000 adults having high-energy fracture repair will receive the nasal treatment. The goal is to see if this simple step reduces infections, especially those caused by staph bacteria.

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Contacts and locations

Locations

  • Emory University

    Atlanta, Georgia, 30303, United States

  • University of Indiana

    Indianapolis, Indiana, 46202, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Texas Southwestern

    Dallas, Texas, 75235, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.