Could one extra shot after a root canal cut pain and pill use?
NCT ID NCT06655454
First seen Apr 15, 2026 · Last updated Jun 22, 2026 · Updated 14 times
Summary
This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned to receive the extra anesthetic, a placebo injection, or no extra injection. Researchers will track pain levels and quality of life for four days after treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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New York University College of Dentistry
RECRUITINGNew York, New York, 10010, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bupivacaine with epinephrine
What this could lead to
If it works, this could offer a simple way to reduce pain and the need for painkillers after a root canal.
What could go wrong
This is a small, early-phase trial, so results may not apply to everyone. The extra injection may not provide meaningful benefit over a placebo or no injection.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.