New drug aims to fight deadly wasting in pancreatic cancer patients

NCT ID NCT06989437

Recruiting now Symptom relief Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 31 times

Summary

This study tests if adding ponsegromab to standard chemotherapy can help adults with advanced pancreatic cancer who are losing weight and have poor appetite (cachexia). About 982 participants will receive either ponsegromab or a placebo alongside their first chemo treatment. The main goals are to see if the drug helps maintain body weight and improve appetite-related quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Affiliated Hospital of Hebei University
NOT_YET_RECRUITING

Baoding, Hebei, 071000, China
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center
RECRUITING

Seoul, Seoul Teukbyeolsi, 05505, South Korea
Baylor Scott & White Vasicek Cancer Treatment Center
NOT_YET_RECRUITING

Temple, Texas, 76508, United States
Beijing Tsinghua Changgung Hospital
NOT_YET_RECRUITING

Beijing, 102218, China
CARTI Cancer Center
NOT_YET_RECRUITING

Little Rock, Arkansas, 72205, United States
CHA Bundang Medical Center, CHA University
RECRUITING

Seongnam-si, Kyǒnggi-do, 13496, South Korea
CIUSSS- saguenay-Lac-Saint-Jean
RECRUITING

Chicoutimi, Quebec, G7H 5H6, Canada
Cancer Care Specialists of Illinois
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Hospital Chinese Academy of Medical Science
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100021, China
Cancer Hospital Chinese Academy of Medical Science
NOT_YET_RECRUITING

Langfang, Hebei, 065001, China
Cardiology Associates, Inc
RECRUITING

‘Aiea, Hawaii, 96701, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
NOT_YET_RECRUITING

Bryant, Arkansas, 72022, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
NOT_YET_RECRUITING

Conway, Arkansas, 72034, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
NOT_YET_RECRUITING

North Little Rock, Arkansas, 72117, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
NOT_YET_RECRUITING

Pine Bluff, Arkansas, 71603, United States
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
RECRUITING

Greenfield Park, Quebec, J4V 2H1, Canada
Centro de Atención e Investigación Cardiovascular del Potosí S.C.
NOT_YET_RECRUITING

San Luis Potosí City, 78200, Mexico
Centro de Investigacion Clinica de Oaxaca
NOT_YET_RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Chao Family Comprehensive Cancer Center and Ambulatory Care
NOT_YET_RECRUITING

Irvine, California, 92612, United States
Chiba cancer center
RECRUITING

Chiba, Chiba, 260-8717, Japan
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Chittaranjan National Cancer Institute
NOT_YET_RECRUITING

Kolkata, West Bengal, 700160, India
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Georgetown University Medical Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Guangdong General Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Hope and Healing Cancer Services
RECRUITING

Hinsdale, Illinois, 60521, United States
Hope and Healing Cancer Services New Lenox
RECRUITING

New Lenox, Illinois, 60451, United States
Hospital Moinhos de Vento
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90560032, Brazil
Hospital Santa Rita de Cassia
RECRUITING

Vitória, Espírito Santo, 29041-295, Brazil
Houston Methodist Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Huzhou Central Hospital
NOT_YET_RECRUITING

Huzhou, Zhejiang, 313000, China
ICON Cancer Centre - Kurralta Park
NOT_YET_RECRUITING

Kurralta Park, South Australia, 5037, Australia
Icesp - Instituto Do Câncer Do Estado de São Paulo
NOT_YET_RECRUITING

São Paulo, 01246-000, Brazil
Icon Cancer Centre Hobart
RECRUITING

Hobart, Tasmania, 7000, Australia
Inha University Hospital
RECRUITING

Incheon, Incheon-gwangyeoksi [incheon], 22332, South Korea
Inje University Haeundae Paik Hospital
RECRUITING

Busan, 48108, South Korea
Invision, LLC
RECRUITING

Honolulu, Hawaii, 96813, United States
JHU Oncology Central Kit Services
NOT_YET_RECRUITING

Baltimore, Maryland, 21205, United States
Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Johns Hopkins Hospital
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Kagawa University Hospital
RECRUITING

Kita-gun, Kagawa-ken, 761-0793, Japan
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 2418515, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Keimyung University Dongsan Hospital
RECRUITING

Daegu, Taegu-kwangyǒkshi, 42601, South Korea
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Liga Norte Riograndense Contra o Câncer
NOT_YET_RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Nebraska Medicine
NOT_YET_RECRUITING

Omaha, Nebraska, 68105, United States
Nebraska Medicine - Village Pointe
NOT_YET_RECRUITING

Omaha, Nebraska, 68118, United States
OHSU Center for Health & Healing 1
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
OSHU Center for Health and Healing 2
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Oncocentro
NOT_YET_RECRUITING

Belo Horizonte, Minas Gerais, 30.360-680, Brazil
Oncology Investigational Drug Service (IDS)
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Oregon Health and Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Pan American Center for Oncology Trials, LLC - Dorado Office
RECRUITING

Dorado, 00646, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
RECRUITING

Mayagüez, 00680, Puerto Rico
Peking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100730, China
Providence Medical Foundation
NOT_YET_RECRUITING

Santa Rosa, California, 95403, United States
Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rajiv Gandhi Cancer Institute And Research Centre
RECRUITING

New Delhi, National Capital Territory of Delhi, 110085, India
Rambam Health Care Campus
RECRUITING

Haifa, Heifa, 3109601, Israel
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Renown Office of Clinical Research
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
Sawai Man Singh Medical College Hospital (SMS Hospital)
NOT_YET_RECRUITING

Jaipur, Rajasthan, 302004, India
Second Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730030, China
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Jerusalem, 9103102, Israel
Shanghai General Hospital
NOT_YET_RECRUITING

Shanghai, 200080, China
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Shoalhaven District Memorial Hospital
NOT_YET_RECRUITING

Nowra, New South Wales, 2541, Australia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310015, China
Sourasky Medical Center
RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
St. Marianna University Hospital
RECRUITING

Kawasaki, Kanagawa, 216-8511, Japan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tata Memorial Hospital
RECRUITING

Mumbai, Maharashtra, 400012, India
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06591, South Korea
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
The First Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
The Kirklin Clinic of UAB Hospital
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
The Ottawa Hospital - General Campus
NOT_YET_RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Second Hospital of Dalian Medical University
NOT_YET_RECRUITING

Dalian, Liaoning, 116004, China
The University of Alabama at Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35294, United States
The University of Hong Kong-Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518053, China
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan
UC Irvine Health
NOT_YET_RECRUITING

Orange, California, 92868, United States
UCI Health - Irvine
NOT_YET_RECRUITING

Irvine, California, 92612, United States
UCLA Department of Medicine - Hematology/Oncology
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UCLA Hematology/Oncology - Santa Monica
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
UNC Hospitals, The University of North Carolina at Chapel Hill
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27514, United States
University Cancer & Blood Center, LLC
RECRUITING

Athens, Georgia, 30607, United States
University Hospital,Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University of Hawaii Cancer Center
RECRUITING

Honolulu, Hawaii, 96813, United States
University of Kentucky Healthcare - Markey Cancer Center
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Kentucky Medical Center
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Kentucky Research Foundation
NOT_YET_RECRUITING

Lexington, Kentucky, 40506, United States
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Nebraska Medical Center
NOT_YET_RECRUITING

Omaha, Nebraska, 68198, United States
University of North Carolina Hospitals at Hillsborough
NOT_YET_RECRUITING

Hillsborough, North Carolina, 27278, United States
University of Rochester Medical Center
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
Venkateshwar Hospital
NOT_YET_RECRUITING

New Delhi, National Capital Territory of Delhi, 110075, India
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan
Wakayama Minami Radiology Clinic
RECRUITING

Wakayama-shi Kimiidera 870-2, Wakayama, 641-0012, Japan
Western Health-Sunshine & Footscray Hospitals
NOT_YET_RECRUITING

St Albans, Victoria, 3021, Australia
Westmead Hospital
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Yamaguchi University Hospital
RECRUITING

Ube, Yamaguchi, 755-8505, Japan

Conditions

Explore the condition pages connected to this study.

CACHEXIA METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA