New drug aims to fight deadly wasting in pancreatic cancer patients

NCT ID NCT06989437

Recruiting now Symptom relief Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests a drug called ponsegromab combined with standard chemotherapy to see if it helps adults with advanced pancreatic cancer who are losing weight and appetite (cachexia). About 982 participants will receive either ponsegromab or a placebo alongside their first chemotherapy. The main goals are to see if the drug helps maintain body weight and improve appetite-related quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Anorexia Cachexia Fatigue neoplasm Neoplasm Metastasis pancreatic ductal adenocarcinoma pancreatic neoplasm Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CACHEXIA METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AZ Turnhout - Campus Sint-Elizabeth
RECRUITING

Turnhout, Antwerpen, 2300, Belgium
Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Affiliated Hospital of Hebei University
RECRUITING

Baoding, Hebei, 071000, China
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Anhui Provincial Hospital
RECRUITING

Hefei, Anhui, 230071, China
Apotheke am Universitätsklinikum Leipzig
NOT_YET_RECRUITING

Leipzig, Saxony, 04103, Germany
Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, Seoul Teukbyeolsi, 05505, South Korea
Atlantic Health System / Morristown Medical Center
NOT_YET_RECRUITING

Morristown, New Jersey, 07960, United States
Atlantic Health System / Overlook Medical Center
NOT_YET_RECRUITING

Summit, New Jersey, 07901, United States
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy
Azienda Ospedaliera Universitaria Ospedali Riuniti - Foggia
RECRUITING

Foggia, 71122, Italy
Azienda Ospedaliero Universitaria delle Marche
RECRUITING

Ancona, 60126, Italy
Baylor Scott & White Vasicek Cancer Treatment Center
RECRUITING

Temple, Texas, 76508, United States
Beijing Tsinghua Changgung Hospital
RECRUITING

Beijing, 102218, China
CARTI Cancer Center
RECRUITING

Little Rock, Arkansas, 72205, United States
CHA Bundang Medical Center, CHA University
RECRUITING

Seongnam-si, Kyǒnggi-do, 13496, South Korea
CIUSSS- saguenay-Lac-Saint-Jean
RECRUITING

Chicoutimi, Quebec, G7H 5H6, Canada
Cancer Care Specialists of Illinois
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Hospital Chinese Academy of Medical Science
RECRUITING

Beijing, Beijing Municipality, 100021, China
Cancer Hospital Chinese Academy of Medical Science
RECRUITING

Langfang, Hebei, 065001, China
Cardiology Associates, Inc
RECRUITING

‘Aiea, Hawaii, 96701, United States
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
RECRUITING

Bryant, Arkansas, 72022, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
RECRUITING

Conway, Arkansas, 72034, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
RECRUITING

North Little Rock, Arkansas, 72117, United States
Central Arkansas Radiation Therapy Institute, dba CARTI
RECRUITING

Pine Bluff, Arkansas, 71603, United States
Centre Hospitalier Universitaire de Poitiers
NOT_YET_RECRUITING

Poitiers, Vienne, 86021, France
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
RECRUITING

Greenfield Park, Quebec, J4V 2H1, Canada
Centro de Atención e Investigación Cardiovascular del Potosí S.C.
RECRUITING

San Luis Potosí City, 78200, Mexico
Centro de Investigacion Clinica de Oaxaca
RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States
Chiba cancer center
RECRUITING

Chiba, Chiba, 260-8717, Japan
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Chittaranjan National Cancer Institute
RECRUITING

Kolkata, West Bengal, 700160, India
Cliniques universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, Bruxelles-capitale, Région de, 1200, Belgium
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Fakultna nemocnica Trencin
NOT_YET_RECRUITING

Trenčín, Trenčín Region, 911 01, Slovakia
Fakultna nemocnica Trnava
RECRUITING

Trnava, 917 75, Slovakia
Fakultna nemocnica s poliklinikou Nove Zamky
RECRUITING

Nové Zámky, 940 34, Slovakia
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Grand Hôpital de Charleroi
RECRUITING

Charleroi, Hainaut, 6060, Belgium
Guangdong General Hospital
RECRUITING

Guangzhou, Guangdong, 510080, China
Gustave Roussy
NOT_YET_RECRUITING

Villejuif, Val-de-marne, 94800, France
Guy's & St Thomas' NHS Foundation Trust
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29011, Spain
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Hammersmith Hospital
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Henri Mondor Hospital
RECRUITING

Créteil, Val-de-marne, 94010, France
Hope and Healing Clinical Research LLC
RECRUITING

Hinsdale, Illinois, 60521, United States
Hope and Healing Clinical Research LLC New Lenox- Research Department
RECRUITING

New Lenox, Illinois, 60451, United States
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Catalunya [cataluña], 08036, Spain
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90560032, Brazil
Hospital Santa Rita de Cassia
RECRUITING

Vitória, Espírito Santo, 29041-295, Brazil
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Huzhou Central Hospital
RECRUITING

Huzhou, Zhejiang, 313000, China
Hôpital Universitaire Paul Brousse
RECRUITING

Villejuif, 94800, France
ICON Cancer Centre - Kurralta Park
RECRUITING

Kurralta Park, South Australia, 5037, Australia
Icahn School of Medicine at Mount Sinai
NOT_YET_RECRUITING

New York, New York, 10029, United States
Icesp - Instituto Do Câncer Do Estado de São Paulo
RECRUITING

São Paulo, 01246-000, Brazil
Icon Cancer Centre Hobart
RECRUITING

Hobart, Tasmania, 7000, Australia
Inha University Hospital
RECRUITING

Incheon, Incheon-gwangyeoksi [incheon], 22332, South Korea
Inje University Haeundae Paik Hospital
RECRUITING

Busan, 48108, South Korea
Institut Jules Bordet
NOT_YET_RECRUITING

Brussels, 1000, Belgium
Invision, LLC
RECRUITING

Honolulu, Hawaii, 96813, United States
JHU Oncology Central Kit Services
RECRUITING

Baltimore, Maryland, 21205, United States
Jack & Sheryl Morris Cancer Center
RECRUITING

New Brunswick, New Jersey, 08901, United States
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Kagawa University Hospital
RECRUITING

Kita-gun, Kagawa-ken, 761-0793, Japan
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 2418515, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Keimyung University Dongsan Hospital
RECRUITING

Daegu, Taegu-kwangyǒkshi, 42601, South Korea
Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie
NOT_YET_RECRUITING

Leipzig, Saxony, 04103, Germany
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Liga Norte Riograndense Contra o Câncer
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
MHAT - Sveta Sofia EOOD
RECRUITING

Sofia, 1618, Bulgaria
MHAT for Women's Health Nadezhda
RECRUITING

Sofia, 1330, Bulgaria
Mayo Clinic
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Cancer Center Outpatient Pharmacy
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Pharmacy
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Medical Center Futuremeds
RECRUITING

Plovdiv, 4002, Bulgaria
MidAmerica Cancer Care - American Oncology Partners
RECRUITING

Kansas City, Missouri, 64132, United States
MidAmerica Cancer Care- American Oncology Partners
RECRUITING

Merriam, Kansas, 66204, United States
Narodny onkologicky ustav
RECRUITING

Bratislava, 833 10, Slovakia
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
RECRUITING

Warsaw, Masovian Voivodeship, 02-034, Poland
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Nebraska Medicine
RECRUITING

Omaha, Nebraska, 68105, United States
Nebraska Medicine - Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.
RECRUITING

Michalovce, 07101, Slovakia
Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda
NOT_YET_RECRUITING

Milan, Milan, 20162, Italy
OHSU Center for Health & Healing 1
RECRUITING

Portland, Oregon, 97239, United States
OSHU Center for Health and Healing 2
RECRUITING

Portland, Oregon, 97239, United States
Oncocentro
RECRUITING

Belo Horizonte, Minas Gerais, 30.360-680, Brazil
Oncology Investigational Drug Service (IDS)
RECRUITING

Baltimore, Maryland, 21287, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Pan American Center for Oncology Trials, LLC - Dorado Office
RECRUITING

Dorado, 00646, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
RECRUITING

Mayagüez, 00680, Puerto Rico
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Premier Imaging
RECRUITING

Kansas City, Missouri, 64114, United States
Princess Margaret Cancer Centre - University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States
Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
RWJ University Hospital Somerset, Steeplechase Cancer Center
RECRUITING

Somerville, New Jersey, 08876, United States
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rajiv Gandhi Cancer Institute And Research Centre
RECRUITING

New Delhi, National Capital Territory of Delhi, 110085, India
Rambam Health Care Campus
RECRUITING

Haifa, Heifa, 3109601, Israel
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Renown Office of Clinical Research
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Royal Free Hospital
RECRUITING

London, England, NW32QG, United Kingdom
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
Rwj University Hospital Somerset
RECRUITING

Somerville, New Jersey, 08876, United States
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
Sana Klinikum Lichtenberg
NOT_YET_RECRUITING

Berlin, 10365, Germany
Sawai Man Singh Medical College Hospital (SMS Hospital)
RECRUITING

Jaipur, Rajasthan, 302004, India
Second Hospital of Lanzhou University
RECRUITING

Lanzhou, Gansu, 730030, China
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Jerusalem, 9103102, Israel
Shanghai General Hospital
RECRUITING

Shanghai, 200080, China
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Shoalhaven District Memorial Hospital
RECRUITING

Nowra, New South Wales, 2541, Australia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
RECRUITING

Baltimore, Maryland, 21287, United States
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310015, China
Sourasky Medical Center
RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Specjalistyczny Szpital Onkologiczny NU-MED Sp. z o.o.
RECRUITING

Tomaszów Mazowiecki, 97-200, Poland
St. Joseph Medical Center
RECRUITING

Kansas City, Missouri, 64114, United States
St. Marianna University Hospital
RECRUITING

Kawasaki, Kanagawa, 216-8511, Japan
Sunnybrook Research Institute
NOT_YET_RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko - Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, Warmian-Masurian Voivodeship, 10-228, Poland
Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie
RECRUITING

Koszalin, 75-581, Poland
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tata Memorial Hospital
RECRUITING

Mumbai, Maharashtra, 400012, India
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06591, South Korea
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, 450000, China
The First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, Shanxi, 030001, China
The Kirklin Clinic of UAB Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
The Ottawa Hospital - General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Second Hospital of Dalian Medical University
RECRUITING

Dalian, Liaoning, 116004, China
The University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
The University of Hong Kong-Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518053, China
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan
UC Irvine Health
RECRUITING

Orange, California, 92868, United States
UC San Diego Koman Family Outpatient Pavilion
RECRUITING

La Jolla, California, 92037, United States
UC San Diego McGrath Outpatient Pavilion - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Medical Center - Bankers Hill
RECRUITING

San Diego, California, 92101, United States
UC San Diego Medical Center - Encinitas
RECRUITING

Encinitas, California, 92024, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
RECRUITING

La Jolla, California, 92037, United States
UC San Diego Medical Center - Rancho Bernardo
RECRUITING

San Diego, California, 92127, United States
UC San Diego Medical Center - Vista
RECRUITING

Vista, California, 92081, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92037, United States
UC San Diego Sulpizio Cardiovascular Center
RECRUITING

La Jolla, California, 92037, United States
UCI Health - Irvine
RECRUITING

Irvine, California, 92612, United States
UCLA Department of Medicine - Hematology/Oncology
RECRUITING

Los Angeles, California, 90095, United States
UCLA Hematology/Oncology - Santa Monica
RECRUITING

Santa Monica, California, 90404, United States
UNC Hospitals, The University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
UZ Leuven
RECRUITING

Leuven, Vlaams-brabant, 3000, Belgium
United Imaging Consultants
RECRUITING

Lenexa, Kansas, 66215, United States
Unity Health Toronto, St. Michael's Hospital
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
NOT_YET_RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Duesseldorf
NOT_YET_RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
University Cancer & Blood Center, LLC
RECRUITING

Athens, Georgia, 30607, United States
University Hospital,Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, 602-8566, Japan
University Multiprofile Hospital for Active Treatment Sofiamed
RECRUITING

Sofia, 1797, Bulgaria
University of Hawaii Cancer Center
RECRUITING

Honolulu, Hawaii, 96813, United States
University of Kentucky Healthcare - Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Kentucky Research Foundation
RECRUITING

Lexington, Kentucky, 40506, United States
University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO)
RECRUITING

Lexington, Kentucky, 40536, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of North Carolina Hospitals at Hillsborough
RECRUITING

Hillsborough, North Carolina, 27278, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Texas Southwestern Medical Center - Simmons Cancer Center
RECRUITING

Dallas, Texas, 75235, United States
University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital
RECRUITING

Dallas, Texas, 75235, United States
University of Texas Southwestern Medical Center-Zale Lipshy University Hospital
RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Universität Leipzig - Med. Fakultät
NOT_YET_RECRUITING

Leipzig, Saxony, 04103, Germany
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, 60-569, Poland
Venkateshwar Hospital
RECRUITING

New Delhi, National Capital Territory of Delhi, 110075, India
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States
Vychodoslovensky Onkologicky ustav a.s.
RECRUITING

Košice, 041 91, Slovakia
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan
Wakayama Minami Radiology Clinic
RECRUITING

Wakayama-shi Kimiidera 870-2, Wakayama, 641-0012, Japan
Western Health-Sunshine & Footscray Hospitals
RECRUITING

St Albans, Victoria, 3021, Australia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Yamaguchi University Hospital
RECRUITING

Ube, Yamaguchi, 755-8505, Japan
Zhongshan Hospital Fudan University
NOT_YET_RECRUITING

Shanghai, 200032, China