New drug combo aims to let CML patients stop treatment

NCT ID NCT04070443

First seen Nov 18, 2025 · Last updated May 10, 2026 · Updated 24 times

Summary

This study tests if a strong drug (ponatinib) given for 6 months, followed by a standard drug (imatinib), can help people with chronic myeloid leukemia reach a deep remission. The goal is to see if patients can eventually stop all medication and stay cancer-free. The trial involves 170 adults aged 18 to 65 who are newly diagnosed.

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Contacts and locations

Locations

  • CH d'Avignon

    Avignon, 84000, France

  • CH de Versailles - Hôpital André Mignot

    Le Chesnay, France

  • CHRU Nancy/Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • CHU Limoges - Hôpital Dupuytren

    Limoges, France

  • CHU Nîmes Caremeau - Institut de Cancérologie du Gard

    Nîmes, France

  • CHU Strasbourg

    Strasbourg, 67000, France

  • CHU d'Angers

    Angers, France

  • CHU de Grenoble

    Grenoble, 38000, France

  • Centre Hospitalier Annecy-Genevois

    Annecy, 74000, France

  • Centre Hospitalier Sud Francilien

    Corbeil-Essonnes, 91000, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • Chru Besançon

    Besançon, 25000, France

  • Chru Brest

    Brest, France

  • Chu - Hopital de Pontchaillou

    Rennes, 35000, France

  • Chu Amiens Picardie

    Amiens, 80000, France

  • Chu D'Estaing

    Clermont-Ferrand, 63000, France

  • Chu Hotel Dieu

    Nantes, 44000, France

  • Chu Poitiers

    Poitiers, France

  • Hopital Henri Mondor

    Créteil, 94000, France

  • Hopital Paul Brousse

    Villejuif, 94800, France

  • Hopital Saint Eloi

    Montpellier, 34000, France

  • Hopital Saintantoine

    Paris, 75000, France

  • Hôpital Claude Huriez - CHRU de Lille

    Lille, France

  • Institut Bergonie

    Bordeaux, 33000, France

  • Institut D'Hematologie de Basse Normandie

    Caen, 14000, France

  • Institut Paoli Calmettes

    Marseille, 13000, France

  • Institut de Cancérologie Lucien Neuwirth

    Saint-Priest-en-Jarez, France

  • Iuct Toulouse - Oncopole

    Toulouse, France

Conditions

Explore the condition pages connected to this study.