New hope for kids battling leukemia that Won't quit

NCT ID NCT04501614

Terminated Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

Summary

This study tested a drug called ponatinib, given with standard chemotherapy, for children and young adults up to age 21 with a specific type of leukemia that had come back or stopped responding to other treatments. The main goals were to find a safe dose and see if the combination could put the cancer into remission. The trial was terminated early after enrolling only 11 participants.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alfred I Dupont Hospital For Children

Wilmington, Delaware, 19803, United States
Ann and Robert H Lurie Childrens Hospital of Chicago

Chicago, Illinois, 60611, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Asan Medical Center - PPDS

Seoul, 5505, South Korea
Assistance Publique Hopitaux de Marseille

Marseille, 13385, France
Cambridge University Hospitals NHS Foundation Trust

Cambridge, CB2 0QQ, United Kingdom
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Chongqing Medical University

Chongqing, 400014, China
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Shanghai

Shanghai, 200040, China
Children's Hospital of Soochow University

Suzhou, 215025, China
Children's Mercy Hospital and Clinica

Kansas City, Missouri, 64108, United States
Childrens Medical Center Research Institute at UT Southwestern

Dallas, Texas, 75235-9063, United States
Cincinnati Children's Hospital Medical Center - PIN

Cincinnati, Ohio, 45229, United States
Fakultni nemocnice Brno

Brno, 61300, Czechia
Fakultni nemocnice v Motole

Prague, 15006, Czechia
Fndazione MBBM (MONZA E BRIANZA PER IL BAMBINO E LA SUA MAMMA) - c/o Centro Maria Letizia Verga

Monza, Lombardy, 20900, Italy
Fundacao Pio XII Hospital de Cancer de Barretos

Barretos, São Paulo, 14784-400, Brazil
Graacc Grupo de Apoio Ao Adolescente E A Crianca Com Cancer

São Paulo, 04039-001, Brazil
Hopital Des Enfants

Toulouse, 31059, France
Hopital Robert Debre

Paris, 75019, France
Hopital Sud

Rennes, Ille-et-Vilaine, 35200, France
Hospital Das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP

Ribeirão Preto, 14051-140, Brazil
Hospital Infantil Universitario Nino Jesus - PIN

Madrid, 28009, Spain
Hospital Italiano de Buenos Aires

Buenos Aires, C1199ABB, Argentina
Hospital Santa Marcelina

São Paulo, 08270-070, Brazil
Hospital Universitario Austral

Pilar, Buenos Aires, B1629AHJ, Argentina
Hospital Universitario Dr. Jose Eleuterio Gonzalez

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario Vall d'Hebron - PPDS

Barcelona, 8035, Spain
Hospital Universitario Virgen del Rocio - PPDS

Seville, 41013, Spain
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

Porto Alegre, Rio Grande Du Sul, 90035-903, Brazil
IRCCS Ospedale Pediatrico Bambino Gesu - INCIPIT - PIN

Rome, Lazio, 165, Italy
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

Tianjin, 300020, China
Instituto Nacional de Pediatria

Mexico City, 4530, Mexico
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS

Porto, 4200-072, Portugal
Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E.

Lisbon, Lisbon District, 1099-023, Portugal
Irmandade Da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande Du Sul, 90020-090, Brazil
Istituto G Gaslini Ospedale Pediatrico IRCCS - INCIPIT - PIN

Genoa, Liguria, 16147, Italy
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca

Guadalajara, 44340, Mexico
Ospedale Infantile Regina Margherita - INCIPIT - PIN

Turin, Piedmont, 10126, Italy
Perth Childrens Hospital

Nedlands, Western Australia, 6009, Australia
Princess Maxima Center for Pediatric Oncology - PIN

Utrecht, 3584 CS, Netherlands
Qilu Hospital of Shandong University

Jinan, 250012, China
Queensland Childrens Hospital

South Brisbane, Queensland, 4101, Australia
Rady Childrens Hospital San Diego - PIN

San Diego, California, 92123, United States
Riley Hospital For Children

Indianapolis, Indiana, 46202-5128, United States
Royal Children's Hospital Melbourne - PIN

Parkville, Victoria, 3052, Australia
Royal Hospital for Children (Glasgow) - PPDS - PIN

Glasgow, G3 8SJ, United Kingdom
Royal Marsden Hospital - Surrey

Surrey Quays, Sutton, SM2 5PT, United Kingdom
Rua Ramiro Barcelos, 2350

Curitiba, Paraná, 81520-060, Brazil
SPSK Nr 1 im. Prof.Stanislawa Szyszko Slaskiego Uniwersytetu Medycznego

Zabrze, 41-800, Poland
Seoul National University Hospital

Seoul, 3080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 3722, South Korea
Shanghai Childrens Medical Center

Shanghai, 200127, China
St Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
The Affiliated Hospital of Guizhou Medical University

Guiyang, 550004, China
The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 6591, South Korea
The Second Hospital of Anhui Medical University

Hefei, 230601, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, 430030, China
UCSF Medical Comprehensive Cancer

San Francisco, California, 94143-3010, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, 430022, China
Uniwersytecki Szpital Dzieciecy

Krakow, 30-663, Poland
West China Second University Hospital, Sichuan Univesity

Chengdu, 610041, China

Conditions

Explore the condition pages connected to this study.

PEDIATRIC PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (PH+ALL) PH+ MIXED PHENOTYPE ACUTE LEUKEMIA (MPAL) PHILADELPHIA CHROMOSOME-LIKE ALL (PH-LIKE ALL)