New drug shows promise for aggressive leukemia but carries serious clot risk
NCT ID NCT01570868
First seen Jan 06, 2026 · Last updated May 14, 2026 · Updated 23 times
Summary
This study tested the drug ponatinib in 51 adults with a fast-growing form of chronic myeloid leukemia (CML) who had little or no prior treatment. The goal was to see if ponatinib could control the disease by blocking a protein that drives leukemia growth. However, the drug can cause dangerous blood clots in about 1 in 4 patients, which may lead to heart attack or stroke. The study was stopped early, but results help doctors understand the benefits and risks of using ponatinib as an initial therapy.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
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