New drug duo aims to outperform current PNH treatments in major trial

NCT ID NCT05133531

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing a new combination of two drugs, pozelimab and cemdisiran, for people with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disease. The main goal is to see if this new combination is more effective and safe than two existing standard treatments, ravulizumab and eculizumab. Researchers will measure how well it controls the destruction of red blood cells and reduces the need for blood transfusions.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A Beneficencia Portuguesa de Sao Paulo, BP Mirante
RECRUITING

São Paulo, 01321-001, Brazil

Contact Phone: •••-•••-•••• Email: •••••@•••••
Ajou University Medical Center
RECRUITING

Suwon, Gyeonggi-do, 16499, South Korea
Amrita Institute of Medical Sciences (AIMS) and Research Centre Aims
RECRUITING

Kochi, Kerala, 682041, India
Aou Careggi
RECRUITING

Florence, Firenze, 50139, Italy
Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC)
RECRUITING

Jaipur, 302017, India
Casa de Saude Santa Marcelina
RECRUITING

São Paulo, 08270-070, Brazil

Contact Phone: •••-•••-•••• Email: •••••@•••••
Centro de Estudos e Pesquisas em Hematologia e Oncologia
RECRUITING

Santo André, São Paulo, 09060-650, Brazil

Contact Email: •••••@•••••
Chaing Mai University
RECRUITING

Chiang Mai, 50200, Thailand
Chang Gung Memorial Hospital - Linkou Branch
RECRUITING

Taoyuan District, Hunan Province, 33305, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua, 500-06, Taiwan
China Medical University Hospital
RECRUITING

Taichung, Central Taiwan, 40447, Taiwan
Clinica San Felipe
RECRUITING

Lima, 15072, Peru
Clinical Research Center, Faculty of Medicine, Prince of Songkla University
RECRUITING

Hat Yai, Changwat Songkhla, 90110, Thailand
Ege University
RECRUITING

Izmir, 35100, Turkey (Türkiye)
Ewha Womans University Mokdong Hospital
RECRUITING

Seoul, 07985, South Korea
Faculty of Medicine Khon Kaen University
RECRUITING

Khon Kaen, 40002, Thailand
Fondazione Policlinico Universitario A. Gemelli - IRCCS
RECRUITING

Rome, Roma, 00168, Italy
Gachon University Gil Medical Center
RECRUITING

Incheon, Namdong-Gu, 21565, South Korea
George Papanikolaou Hospital
RECRUITING

Thessaloniki, 57010, Greece
Hematology Citta della Salute e della Scienza di Torino
RECRUITING

Turin, 10126, Italy
Hospital Ampang
RECRUITING

Ampang, Selangor, 68000, Malaysia
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital General JM Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hospital Pablo Tobon Uribe
RECRUITING

Medellín, Antioquia, 050034, Colombia
Hospital Queen Elizabeth
RECRUITING

Kota Kinabalu, Sabah, 88586, Malaysia
Hospital Tg Ampuan Afzan
RECRUITING

Kuantan, Pahang, 25200, Malaysia
Hospital Universitario Basurto
RECRUITING

Bilbao, Vizcaya, 48013, Spain
Hualien Tzu Chi Hospital
RECRUITING

Hualien City, 97002, Taiwan
Institute of Hematology and Transfusion Medicine
RECRUITING

Warsaw, 02-776, Poland
Ion Chiricuta Oncology Institute
RECRUITING

Cluj-Napoca, Cluj, 400015, Romania
Istanbul University
RECRUITING

Istanbul, 34418, Turkey (Türkiye)
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
RECRUITING

Nagoya, Aichi-ken, 466-8650, Japan
Jordan University Hospital (JUH)
RECRUITING

Amman, 11942, Jordan
K J Somaiya Super Specialty Hospital & Research Centre
RECRUITING

Mumbai, Maharashtra, 400022, India
Kaohsiung Medical University Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
King Chulalongkorn Memorial Hospital
RECRUITING

Bangkok, 10330, Thailand
King George Hospital
RECRUITING

Lucknow, Uttar Pradesh, 226003, India
Korea University Hospital
RECRUITING

Seoul, 02841, South Korea
Malabar Cancer Center, Kerala
RECRUITING

Kannur, Kerala, 670103, India
Matsushita Memorial Hospital
RECRUITING

Moriguchi, Osaka, 570-8540, Japan
Municipal Hospital Filantropia
RECRUITING

Craiova, Dolj, 200143, Romania
NTT Medical Center Tokyo
RECRUITING

Shinagawa-ku, Tokyo, 141-8625, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100229, Taiwan
National University Hospital
RECRUITING

Singapore, 119074, Singapore
Ogaki Municipal Hospital
RECRUITING

Ōgaki, Gifu, 503-8502, Japan
Peking Union Medical College Hospital
COMPLETED

Beijing, Beijing Municipality, 100032, China
Postgraduate Institute of Medical Education & Research (PGIMER)
RECRUITING

Chandigarh, Punjab, 708248, India
Pusan National University Hospital
RECRUITING

Busan, 49241, South Korea
Rajavithi Hospital
WITHDRAWN

Bangkok, 10400, Thailand
Rajiv Gandhi Cancer Institute & Research Center (RGCIRC) - Rohini Campus
RECRUITING

New Delhi, National Capital Territory of Delhi, 110085, India
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sanjay Gandhi Postgraduate Institute of Medical Sciences
RECRUITING

Lucknow, Uttar Pradesh, 226014, India
Semmelweis University
RECRUITING

Budapest, 1083, Hungary
Seoul St. Mary's Hospital - The Catholic University of Korea
RECRUITING

Seoul, 065791, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••
Servicio de Hematologia del Hospital Universitario de la Uanl
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
St James Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
St Lukes Medical Center
RECRUITING

Quezon, Central Luzon, 1011, Philippines
St. Vincent Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Szpital Uniwersytecki Nr2 Bydgoszcz
RECRUITING

Bydgoszcz, 85-168, Poland
Taichung Veterans General Hospital (VGHTC)
RECRUITING

Taichung, 4070, Taiwan
Targu Mures Clinical County Emergency Hospital
RECRUITING

Târgu Mureş, Mureș County, 540136, Romania
The Oncology Institute of Hope & Innovation
RECRUITING

Whittier, California, 90602, United States
Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Tri-Service General Hospital
RECRUITING

Taipei, 114, Taiwan
University Clinical Center Medical University of Gdansk
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-214, Poland
University of Tsukuba Hospital
RECRUITING

Tsukuba, Ibaraki, 305-8576, Japan

Conditions

Explore the condition pages connected to this study.

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA