Scientists uncover how PML virus hides from immune system
NCT ID NCT04453917
First seen Jan 09, 2026
Summary
This study looked at 22 people with PML, a rare brain infection caused by the JC virus in those with weakened immune systems. Researchers collected blood, urine, and spinal fluid samples over six months to measure immune checkpoint molecules and antiviral responses. The goal was to see if these molecules help the virus evade the immune system, which could lead to new treatment strategies.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
CHU Bordeaux
Bordeaux, France
-
CHU Montpellier
Montpellier, France
-
CHU de TOULOUSE
Toulouse, 31000, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this research could point toward new treatments for PML by using immune checkpoint blockers to restore antiviral immunity.
What could go wrong
This is a small, observational study with only 22 participants, so results may not apply to all PML patients. It is early-stage research, not a treatment trial.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.