New injection aims to tame dangerous blood fats in major trial

NCT ID NCT06347133

Ongoing Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether a new injectable drug called plozasiran can safely and effectively lower high triglyceride levels in the blood. About 1,456 adults with this condition will receive either the drug or a placebo shot every three months for a year. The main goal is to see how much it reduces triglycerides compared to the placebo and to monitor for any side effects, especially related to blood sugar.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Research Site 1

Birmingham, Alabama, 35205, United States
Research Site 10

Montclair, California, 91763, United States
Research Site 100

CABA, Buenos Aires, 1417, Argentina
Research Site 101

Godoy Cruz, Mendoza Province, 5501, Argentina
Research Site 102

CABA, Buenos Aires, 1128, Argentina
Research Site 103

Ciudad Autonoma Buenos Aires, Buenos Aires, C1430CKE, Argentina
Research Site 104

Córdoba, Córdoba Province, 5000, Argentina
Research Site 105

Rosario, Santa Fe Province, 2000, Argentina
Research Site 106

Córdoba, 5000, Argentina
Research Site 107

Blacktown, New South Wales, 2148, Australia
Research Site 108

Merewether, New South Wales, 2291, Australia
Research Site 109

Heidelberg Heights, Victoria, 3081, Australia
Research Site 11

Oxnard, California, 93030, United States
Research Site 110

Clayton, Victoria, 3168, Australia
Research Site 111

Blagoevgrad, 2700, Bulgaria
Research Site 112

Burgas, 8000, Bulgaria
Research Site 113

Byala, 7100, Bulgaria
Research Site 114

Dimitrovgrad, 6400, Bulgaria
Research Site 115

Haskovo, 6300, Bulgaria
Research Site 116

Kyustendil, 2500, Bulgaria
Research Site 117

Pleven, 5800, Bulgaria
Research Site 118

Pleven, 5800, Bulgaria
Research Site 119

Plovdiv, 4002, Bulgaria
Research Site 12

Redding, California, 96001, United States
Research Site 120

Plovdiv, 4001, Bulgaria
Research Site 121

Plovdiv, 4004, Bulgaria
Research Site 122

Rousse, 7013, Bulgaria
Research Site 123

Sevlievo, 5400, Bulgaria
Research Site 124

Sofia, 1616, Bulgaria
Research Site 125

Sofia, 1618, Bulgaria
Research Site 126

Sofia, 1431, Bulgaria
Research Site 127

Sofia, 1680, Bulgaria
Research Site 128

Sofia, 1750, Bulgaria
Research Site 129

Sofia, 1431, Bulgaria
Research Site 13

Van Nuys, California, 91402, United States
Research Site 130

Sofia, 1510, Bulgaria
Research Site 131

Sofia, 1527, Bulgaria
Research Site 132

Sofia, 1431, Bulgaria
Research Site 133

Sofia, 1336, Bulgaria
Research Site 134

Sofia, 1680, Bulgaria
Research Site 135

Sofia, 1527, Bulgaria
Research Site 136

Stara Zagora, 6010, Bulgaria
Research Site 137

Sofia, 1202, Bulgaria
Research Site 138

Halifax, B3H 1V7, Canada
Research Site 139

Québec, Quebec, G1G 3Y8, Canada
Research Site 14

Colorado Springs, Colorado, 80909, United States
Research Site 140

North Vancouver, British Columbia, V7M 2H4, Canada
Research Site 141

Victoria, British Columbia, V8T 5G4, Canada
Research Site 142

Brampton, Ontario, L6S 0C6, Canada
Research Site 143

Sarnia, Ontario, N7T 4X3, Canada
Research Site 144

Waterloo, Ontario, N2T0C1, Canada
Research Site 145

Chicoutimi, Quebec, G7H 7K9, Canada
Research Site 146

Laval, Quebec, H7T 2P5, Canada
Research Site 147

Québec, Quebec, G1V 4W2, Canada
Research Site 148

Québec, Quebec, J6X 4P7, Canada
Research Site 149

Montreal, Quebec, H2W 1R7, Canada
Research Site 15

Clearwater, Florida, 33756, United States
Research Site 150

Slaný, 27401, Czechia
Research Site 151

Prague, Prague, 140 21, Czechia
Research Site 152

Prague, 101 00, Czechia
Research Site 153

Ústí nad Labem, 40113, Czechia
Research Site 154

Hodonín, 69501, Czechia
Research Site 155

Ostrava, 702 00, Czechia
Research Site 156

Praha 4-Krc, 140 59, Czechia
Research Site 157

Brno, 602 00, Czechia
Research Site 158

Trutnov, 541 01, Czechia
Research Site 159

Hradec Králové, 500 05, Czechia
Research Site 16

Hialeah, Florida, 33016, United States
Research Site 160

Náchod, 547 01, Czechia
Research Site 161

Uherské Hradiště, 686 01, Czechia
Research Site 162

Olomouc, 779 00, Czechia
Research Site 163

Teplice, 41501, Czechia
Research Site 164

Marseille, Bouches du Rhone, 13005, France
Research Site 166

Lyon, Rhone, 69007, France
Research Site 167

Pessac, Gironde, 33604, France
Research Site 168

Magdeburg, Saxony-Anhalt, 39120, Germany
Research Site 169

Wallerfing, Bavaria, 94574, Germany
Research Site 17

Lake City, Florida, 32055, United States
Research Site 170

Deggingen, Baden-Wurttemberg, 73326, Germany
Research Site 171

Békéscsaba, 5600, Hungary
Research Site 172

Pécs, 7623, Hungary
Research Site 173

Veszprém, 8200, Hungary
Research Site 174

Zalaegerszeg, 8900, Hungary
Research Site 175

Budapest, 1033, Hungary
Research Site 176

Miskolc, 3530, Hungary
Research Site 177

Pécs, 7635, Hungary
Research Site 178

Szeged, 6725, Hungary
Research Site 179

Budapest, 1132, Hungary
Research Site 18

Miami Lakes, Florida, 33014, United States
Research Site 180

Budapest, 1152, Hungary
Research Site 182

Kaposvár, 7400, Hungary
Research Site 183

Budapest, 1051, Hungary
Research Site 184

Budapest, 1135, Hungary
Research Site 185

Brescia, 25123, Italy
Research Site 186

Rozzano, Milano, 20089, Italy
Research Site 187

Palermo, Sicily, 90127, Italy
Research Site 188

Milan, 20162, Italy
Research Site 189

Bologna, 40138, Italy
Research Site 19

Mt. Dora, Florida, 32757, United States
Research Site 190

Katowice, 40-156, Poland
Research Site 191

Lodz, 94-255, Poland
Research Site 192

Elblag, 82-300, Poland
Research Site 193

Gdynia, 81-338, Poland
Research Site 194

Malbork, 82-200, Poland
Research Site 195

Zamość, 22-400, Poland
Research Site 196

Wroclaw, 51-314, Poland
Research Site 197

Krakow, 30-727, Poland
Research Site 198

Warsaw, 03-291, Poland
Research Site 199

Szczecin, 71-500, Poland
Research Site 2

Mobile, Alabama, 36604, United States
Research Site 20

North Miami Beach, Florida, 33162, United States
Research Site 200

Bydgoszcz, 85-065, Poland
Research Site 201

Lodz, 91-363, Poland
Research Site 202

Bydgoszcz, 85-231, Poland
Research Site 203

Żarów, 58-130, Poland
Research Site 204

Krakow, 31-501, Poland
Research Site 205

Warsaw, 00-215, Poland
Research Site 206

Wroclaw, 53-673, Poland
Research Site 207

Torun, 87-100, Poland
Research Site 208

Wroclaw, 53-030, Poland
Research Site 209

Nové Zámky, 94002, Slovakia
Research Site 21

Orlando, Florida, 32825, United States
Research Site 210

Košice, 040 01, Slovakia
Research Site 211

Prešov, 8001, Slovakia
Research Site 212

Bardejov, 8501, Slovakia
Research Site 213

Moldava nad Bodvou, 045 01, Slovakia
Research Site 214

Banská Bystrica, 97401, Slovakia
Research Site 215

Rožňava, 4801, Slovakia
Research Site 216

Bratislava, 83101, Slovakia
Research Site 217

Bratislava, 81109, Slovakia
Research Site 218

Žilina, 01001, Slovakia
Research Site 219

Cape Town, Western Cape, 7530, South Africa
Research Site 22

Pensacola, Florida, 32503, United States
Research Site 220

Somerset West, Western Cape, 7130, South Africa
Research Site 221

Centurion, Gauteng, 0157, South Africa
Research Site 222

Krugersdorp, Gauteng, 1739, South Africa
Research Site 223

Cape Town, Western Cape, 7550, South Africa
Research Site 224

Durban, KwaZulu-Natal, 4449, South Africa
Research Site 225

Cape Town, Western Cape, 7925, South Africa
Research Site 226

Pretoria, 0184, South Africa
Research Site 227

Cape Town, Western Cape, 7500, South Africa
Research Site 228

Pretoria, Gauteng, 0181, South Africa
Research Site 229

A Coruña, La Coruña, 15006, Spain
Research Site 23

Sarasota, Florida, 34239, United States
Research Site 230

Barcelona, 08023, Spain
Research Site 231

Valencia, 46010, Spain
Research Site 232

Madrid, 28041, Spain
Research Site 233

Zaragoza, 50009, Spain
Research Site 234

Barcelona, Barcelona, 08035, Spain
Research Site 235

London, EC1M 6BQ, United Kingdom
Research Site 236

Plymouth, Devon, PL5 3JB, United Kingdom
Research Site 24

Tamarac, Florida, 33321, United States
Research Site 25

Lawrenceville, Georgia, 30044, United States
Research Site 26

Macon, Georgia, 31210, United States
Research Site 27

Savannah, Georgia, 31406, United States
Research Site 28

Sugar Hill, Georgia, 30518, United States
Research Site 29

Park Ridge, Illinois, 60068, United States
Research Site 3

Beverly Hills, California, 90211, United States
Research Site 30

Elkhart, Indiana, 46514, United States
Research Site 31

Indianapolis, Indiana, 46290, United States
Research Site 32

South Bend, Indiana, 46617, United States
Research Site 33

Overland Park, Kansas, 66211, United States
Research Site 34

Topeka, Kansas, 66606, United States
Research Site 35

Louisville, Kentucky, 40202, United States
Research Site 36

Zachary, Louisiana, 70791, United States
Research Site 37

Annapolis, Maryland, 21401, United States
Research Site 38

Baltimore, Maryland, 21229, United States
Research Site 39

Flint, Michigan, 48532, United States
Research Site 4

Canoga Park, California, 91303, United States
Research Site 40

Minneapolis, Minnesota, 55455, United States
Research Site 41

Olive Branch, Mississippi, 38654, United States
Research Site 42

Jefferson City, Missouri, 65109, United States
Research Site 43

St Louis, Missouri, 63136, United States
Research Site 44

Norfolk, Nebraska, 68701, United States
Research Site 45

Omaha, Nebraska, 68144, United States
Research Site 46

Omaha, Nebraska, 68114, United States
Research Site 47

Las Vegas, Nevada, 89119, United States
Research Site 48

Summit, New Jersey, 07901, United States
Research Site 49

The Bronx, New York, 10455, United States
Research Site 5

Garden Grove, California, 92844, United States
Research Site 50

The Bronx, New York, 10461, United States
Research Site 51

New York, New York, 10029, United States
Research Site 52

New York, New York, 10016, United States
Research Site 53

Riverhead, New York, 11901, United States
Research Site 54

Rochester, New York, 14642, United States
Research Site 55

Vestal, New York, 13850, United States
Research Site 56

Asheboro, North Carolina, 27203, United States
Research Site 57

Morehead City, North Carolina, 28557, United States
Research Site 58

Wilmington, North Carolina, 28412, United States
Research Site 59

Winston-Salem, North Carolina, 27157, United States
Research Site 6

Huntington Beach, California, 92648, United States
Research Site 60

Beavercreek, Ohio, 45431, United States
Research Site 61

Cincinnati, Ohio, 45267, United States
Research Site 62

Columbus, Ohio, 43214, United States
Research Site 63

Columbus, Ohio, 43210, United States
Research Site 64

Norman, Oklahoma, 73072, United States
Research Site 65

Oklahoma City, Oklahoma, 73112, United States
Research Site 66

Oklahoma City, Oklahoma, 73111, United States
Research Site 67

Horsham, Pennsylvania, 19044, United States
Research Site 68

Newport, Pennsylvania, 17074, United States
Research Site 69

Newport, Pennsylvania, 17074, United States
Research Site 7

Lake Forest, California, 92630, United States
Research Site 70

Philadelphia, Pennsylvania, 19104, United States
Research Site 71

Wilkes-Barre, Pennsylvania, 18711, United States
Research Site 72

Fort Mill, South Carolina, 29707, United States
Research Site 73

Greenville, South Carolina, 29607, United States
Research Site 74

Chattanooga, Tennessee, 37411, United States
Research Site 75

Powell, Tennessee, 37849, United States
Research Site 76

El Paso, Texas, 79905, United States
Research Site 77

Fort Worth, Texas, 76132, United States
Research Site 78

Houston, Texas, 77040, United States
Research Site 79

Houston, Texas, 77090, United States
Research Site 8

Lincoln, California, 95648, United States
Research Site 80

Houston, Texas, 77061, United States
Research Site 81

Houston, Texas, 77095, United States
Research Site 82

Houston, Texas, 77079, United States
Research Site 83

Houston, Texas, 77074, United States
Research Site 84

Houston, Texas, 77030, United States
Research Site 85

Houston, Texas, 77030, United States
Research Site 86

Houston, Texas, 77029, United States
Research Site 87

Laredo, Texas, 78041, United States
Research Site 88

Missouri City, Texas, 77459, United States
Research Site 89

Plano, Texas, 75093, United States
Research Site 9

Long Beach, California, 90822, United States
Research Site 90

San Antonio, Texas, 78230, United States
Research Site 91

Sugar Land, Texas, 77479, United States
Research Site 92

Tomball, Texas, 77375, United States
Research Site 93

Victoria, Texas, 77901, United States
Research Site 94

Bountiful, Utah, 84010, United States
Research Site 95

St. George, Utah, 84790, United States
Research Site 96

Manassas, Virginia, 20110, United States
Research Site 97

Seattle, Washington, 98109, United States
Research Site 98

Córdoba, Córdoba Province, 5006, Argentina
Research Site 99

Rosario, Santa Fe Province, 2000, Argentina
Research Site165

Paris, 75013, France

Conditions

Explore the condition pages connected to this study.

HYPERTRIGLYCERIDEMIA