Can a simple injection tighten loose skin after major weight loss?
NCT ID NCT07637188
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injections of Poly-L-lactic acid (PLLA) can improve skin laxity in people who have loose skin after bariatric surgery. Fifteen participants receive three injections in one thigh over three months, while the other thigh is left untreated. During later plastic surgery, skin samples from both thighs are compared to see if the injections boost collagen and improve skin quality.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Poly-L-lactic acid (PLLA) injections
- What this could lead to
- If it works, this could offer a non-surgical option to improve skin tightness and quality after major weight loss.
- What could go wrong
- This is a very early, small proof-of-concept study with only 15 people. It may not show clear benefits, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Azienda Ospedaliero Universitaria Senese
RECRUITINGSiena, Italy
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