Can a simple injection tighten loose skin after major weight loss?
NCT ID NCT07637188
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injections of Poly-L-lactic acid (PLLA) can improve skin laxity in people who have loose skin after bariatric surgery. Fifteen participants receive three injections in one thigh over three months, while the other thigh is left untreated. During later plastic surgery, skin samples from both thighs are compared to see if the injections boost collagen and improve skin quality.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Poly-L-lactic acid (PLLA) injections
What this could lead to
If it works, this could offer a non-surgical option to improve skin tightness and quality after major weight loss.
What could go wrong
This is a very early, small proof-of-concept study with only 15 people. It may not show clear benefits, and results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliero Universitaria Senese
RECRUITINGSiena, Italy
Contact Email: •••••@•••••