New drug combo aims to wipe out resistant leukemia cells

NCT ID NCT06466122

First seen Mar 21, 2026 · Last updated May 29, 2026 · Updated 10 times

Summary

This study tests a combination of two targeted drugs, pirtobrutinib and venetoclax, in 30 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has stopped responding to standard BTK inhibitor therapy. The goal is to see if the combo can clear cancer cells from the blood and bone marrow. Participants must be currently taking a BTK inhibitor and have signs of disease progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.