Diabetes drug shows promise in early cancer combo trial

NCT ID NCT02133625

First seen Apr 14, 2026 · Last updated May 12, 2026 · Updated 4 times

Summary

This early-phase trial tested the safety and best dose of combining the diabetes drug pioglitazone with the chemotherapy carboplatin in 14 people with advanced or metastatic solid tumors that could not be cured with standard treatments. The goal was to find the maximum tolerated dose and describe any side effects. The study also looked at whether pioglitazone changed how carboplatin works in the body.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

Conditions

Explore the condition pages connected to this study.