Parkinson's psychosis drug shows promise in final trial

NCT ID NCT06068465

Completed Symptom relief Sponsor: Tasly Pharmaceutical Group Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the drug pimavanserin can safely reduce hallucinations and delusions in people with Parkinson's disease psychosis. 248 participants took either the drug or a placebo daily for 6 weeks. The main goal was to see if symptoms improved, measured by a standard rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pimavanserin (also known as NUPLAZID)

What this could lead to

If it works, this could provide a treatment option to ease hallucinations and delusions in people with Parkinson's disease.

What could go wrong

This is a completed phase 3 trial, but results are not yet published. The drug may not prove more effective than placebo, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON'S DISEASE PSYCHOSIS

Contacts and locations

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Locations

Beijing Hospital

Beijing, Beijing Municipality, 100005, China
Guangdong Provincial Peoples Hospital

Guangzhou, Guangdong, 510000, China
Huai'an Second People's Hospital

Huaian, Jiangsu, 223022, China
Inner Mongolia Autonomous Region People's Hospital

Hohhot, Inner Mongolia, 010000, China
Mianyang Central Hospital

Mianyang, Sichuan, 621099, China
Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210008, China
Peking University Sixth Hospital

Beijing, Beijing Municipality, 100191, China
People's Hospital of Ningxia Hui Autonomous Region

Yinchuan, Ningxia, 750002, China
Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China
Qilu Hospital of Shandong University(Qingdao)

Qingdao, Shandong, 266035, China
Ruijin Hospital

Shanghai, Shanghai Municipality, 200025, China
The Affiliated Hospital of Guizhou Medical University

Guiyang, Guizhou, 550001, China
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221004, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230061, China
The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Hospital of China Medical University

Shenyang, Liaoning, 110002, China
The First Hospital of Jilin University

Changchun, Jilin, 130021, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330008, China
The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215004, China
The Second Hospital of HeBei Medical University

Shijiazhuang, Hebei, 050005, China
The Third Xiangya Hospital of Central South University

Changsha, Hunan, 410013, China
Tianjin Huanhu Hospital

Tianjin, Tianjin Municipality, 300222, China
West China Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Xuan Wu Hospital

Beijing, Beijing Municipality, 100053, China
Zhongda Hospital Southeast University

Nanjing, Jiangsu, 210009, China