Ankle break breakthrough? injection may stop arthritis before it starts
NCT ID NCT03652753
First seen Apr 29, 2026 · Last updated Apr 29, 2026
Summary
This study tests whether injecting N-Acetylcysteine (NAC) into the ankle joint shortly after a severe fracture can protect cartilage cells from dying. About 30 adults with high-energy pilon fractures will receive either NAC or a placebo during their staged surgery. The goal is to reduce the risk of post-traumatic arthritis, a common long-term complication.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Missouri Health System
RECRUITINGColumbia, Missouri, 65212, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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