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Can supervised exercise calm the racing heart of POTS?

NCT ID NCT05554107

Disease control Sponsor: Lund University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This trial tests whether a 16-week supervised exercise program can reduce symptoms of postural orthostatic tachycardia syndrome (POTS), a condition that causes a sharp rise in heart rate and symptoms like dizziness and fatigue when standing. Researchers at Lund University will enroll 200 people diagnosed with POTS. Participants will join group exercise sessions led by physiotherapists or physicians, meeting 2-3 times per week for an hour. The study measures changes in symptom scores using a questionnaire that tracks common POTS complaints like palpitations, nausea, and brain fog.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A 16-week supervised group exercise program, with 2-3 sessions per week of 60 minutes each, led by physiotherapists or physicians.
What this could lead to
If it works, this could establish a practical, supervised exercise program as a standard add-on treatment to help manage POTS symptoms.
What could go wrong
This is an early-stage trial, and exercise may not ease symptoms for everyone. Some patients might find the program hard to complete, and the results may not apply to all POTS patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2022

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with POTS who have given written informed consent for participation in the study. Exclusion Criteria: * Patients with myalgic encephalomyelitis are excluded from the study.

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Conditions

The condition(s) this trial relates to.

Motor Activity Orthostatic Intolerance postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pots - postural orthostatic tachycardia syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Skånes Universitetssjukhus Malmö, Department of Cardiology

    RECRUITING

    Malmö, 214 28, Sweden

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