New drug combo takes on tough lung cancer

NCT ID NCT07226999

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study tests a new medicine called PF-08634404 given with chemotherapy for adults with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. The trial has two parts: first checking safety, then comparing the new combo to an approved treatment (atezolizumab plus chemo). About 550 participants will receive IV infusions in cycles.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08634404 (a new experimental drug) given with chemotherapy
What this could lead to: If it works, this could offer a new treatment option for people with extensive-stage small cell lung cancer, potentially improving survival.
What could go wrong: This is an early-to-mid stage trial, so the drug may not work better than existing treatments. Side effects from the new drug combination are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER ( SCLC )

Contacts and locations

Locations

Azienda Ospedaliero-Universitaria San Luigi Gonzaga
NOT_YET_RECRUITING

Orbassano, Turin, 10043, Italy
BRCR Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States
BRCR Global - Tamarac
RECRUITING

Tamarac, Florida, 33321, United States
CETIR
RECRUITING

Barcelona, 08029, Spain
Centro di Riferimento Oncologico (CRO) IRCCS
RECRUITING

Aviano, Pordenone, 33081, Italy
Doctor's Center Hematology & Oncology Group
RECRUITING

Manati, 00674, Puerto Rico
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, Guangdong, 510180, China
Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
HT Médica Jaen LAs Nieves
RECRUITING

Jaén, Andalusia, 23007, Spain
Highlands Oncology Group
RECRUITING

Fayetteville, Arkansas, 72703, United States
Highlands Oncology Group
RECRUITING

Rogers, Arkansas, 72758, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hospital Jerez de la Frontera
RECRUITING

Jerez de la Frontera, Cádiz, 11407, Spain
Hospital Oncologico Dr. Isaac Gonzalez-Martinez
RECRUITING

San Juan, 00935, Puerto Rico
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario de Jaen
RECRUITING

Jaén, 23007, Spain
Hôpital Ambroise Paré
RECRUITING

Boulogne-Billancourt, Île-de-France Region, 92100, France
IRCCS Istituto Nazionale dei Tumori Regina Elena
RECRUITING

Roma, ROME, 00144, Italy
Japanese Foundation for Cancer Research
NOT_YET_RECRUITING

Kotoku, Tokyo, 135-8550, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Krankenhaus Nordwest GmbH
RECRUITING

Frankfurt am Main, 60488, Germany
Marien Hospital Düsseldorf
RECRUITING

Düsseldorf, 40479, Germany
Mid Florida Hematology and Oncology Center
RECRUITING

Orange City, Florida, 32763, United States
National Cheng Kung University Hospital
RECRUITING

Tainan, 704302, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Blacksburg, Virginia, 24060, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Low Moor, Virginia, 24457, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Roanoke, Virginia, 24014, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Salem, Virginia, 24153, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
RECRUITING

Wytheville, Virginia, 24382, United States
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office Mayaguez Medical Center
RECRUITING

Mayagüez, 00680, Puerto Rico
Parc de Salut Mar - Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Shizuoka Cancer Center
RECRUITING

Nagaizumi-cho, Shizuoka, 411-8777, Japan
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Texas Oncology - DFW
NOT_YET_RECRUITING

Arlington, Texas, 76012, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Arlington, Texas, 76014, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Bedford, Texas, 76022, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Dallas, Texas, 75203, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Dallas, Texas, 75230, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Dallas, Texas, 75231, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Dallas, Texas, 75237, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Grapevine, Texas, 76051, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Plano, Texas, 75075, United States
Texas Oncology - DFW
NOT_YET_RECRUITING

Plano, Texas, 75093, United States
Texas Oncology - Gulf Coast
RECRUITING

Beaumont, Texas, 77702, United States
Texas Oncology - Gulf Coast
RECRUITING

Houston, Texas, 77024, United States
Texas Oncology - Gulf Coast
RECRUITING

Houston, Texas, 77054, United States
Texas Oncology - Gulf Coast
RECRUITING

Pearland, Texas, 77584, United States
Texas Oncology - Gulf Coast
RECRUITING

Sugar Land, Texas, 77479, United States
Texas Oncology - Gulf Coast
RECRUITING

The Woodlands, Texas, 77380, United States
Texas Oncology - Gulf Coast
RECRUITING

Webster, Texas, 77598, United States
Texas Oncology - San Antonio
RECRUITING

Fredericksburg, Texas, 78624, United States
Texas Oncology - San Antonio
RECRUITING

New Braunfels, Texas, 78130, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78217, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78258, United States
US Oncology Investigational Product Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)
NOT_YET_RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
University Hospitals Cleveland Medical Center
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
Virginia Oncology Associates
RECRUITING

Chesapeake, Virginia, 23320, United States
Virginia Oncology Associates
RECRUITING

Hampton, Virginia, 23666, United States
Virginia Oncology Associates
RECRUITING

Newport News, Virginia, 23606, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Virginia Oncology Associates
RECRUITING

Virginia Beach, Virginia, 23456, United States
Virginia Oncology Associates
RECRUITING

Williamsburg, Virginia, 23188, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

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