New hope for advanced breast cancer: experimental pill combo enters final testing phase

NCT ID NCT07062965

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jan 04, 2026 · Last updated May 12, 2026 · Updated 16 times

Summary

This study tests a new oral drug (PF-07248144) combined with fulvestrant in 400 people with advanced HR-positive, HER2-negative breast cancer that worsened after prior CDK4/6 inhibitor treatment. Half receive the new combo; the other half get standard care (everolimus plus endocrine therapy). The goal is to see if the new combination delays cancer growth and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

ANIMI - Unidade de Tratamento Oncologico
RECRUITING

Lages, Santa Catarina, 88501001, Brazil
AZ Groeninge Campus Kennedylaan
RECRUITING

Kortrijk, West-vlaanderen, 8500, Belgium
Afecc Associacao Feminina Educacao Combate Cancer
RECRUITING

Vitória, Espírito Santo, 29043-260, Brazil
Affiliated Hospital of Hebei University
NOT_YET_RECRUITING

Baoding, Hebei, 071066, China
Algemeen Ziekenhuis klina
RECRUITING

Brasschaat, Antwerpen, 2930, Belgium
Anhui Provincial Cancer Hospital
RECRUITING

Hefei, Anhui, 230031, China
Ankara Bilkent Şehir Hastanesi
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Apex Wellness Hospital
NOT_YET_RECRUITING

Nashik, Maharashtra, 422009, India
Bon Secours Cancer Institute at Memorial Regional Medical Center
RECRUITING

Mechanicsville, Virginia, 23116, United States
CHU de Québec-Université Laval
RECRUITING

Québec, G1R 2J6, Canada
CHU de Québec-Université Laval, Hôpital du Saint-Sacrement
RECRUITING

Québec, Quebec, G1S 4L8, Canada
CHUAC-Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, A Coruña [LA Coruña], 15006, Spain
COI Centro Oncologico Internacional S.A.P.I. de C.V.
RECRUITING

Mexico City, 04700, Mexico
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer
NOT_YET_RECRUITING

Rennes, Brittany Region, 35042, France
Centre François Baclesse
NOT_YET_RECRUITING

Caen, 14076, France
Centre Hospitalier Lyon Sud
NOT_YET_RECRUITING

Pierre-Bénite, Rhône, 69310, France
Centre Hospitalier de l'Université de Montréal
NOT_YET_RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Centro de Investigacion Clinica de Oaxaca
RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.
NOT_YET_RECRUITING

Krakow, Lesser Poland Voivodeship, 30-348, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka
NOT_YET_RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
Charité Universitaetsmedizin Berlin - Campus Mitte
RECRUITING

Berlin, 10117, Germany
Chi Mei Medical Center
RECRUITING

Tainan, Tainan, 71004, Taiwan
Cliniques universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, Bruxelles-capitale, Région de, 1200, Belgium
Complex Oncology Center - Shumen
RECRUITING

Shumen, 9700, Bulgaria
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Henderson, Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Las Vegas, Nevada, 89144, United States
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada
NOT_YET_RECRUITING

Las Vegas, Nevada, 89169, United States
Debreceni Egyetem Klinikai Kozpont
NOT_YET_RECRUITING

Debrecen, 4032, Hungary
Dicle Üniversitesi
RECRUITING

Diyarbakır, 21200, Turkey (Türkiye)
Docrates Syöpäsairaala
RECRUITING

Helsinki, Uusimaa, 00180, Finland
Dr. Manoj Khatore, MD, FACC (Cardiology Practice)
NOT_YET_RECRUITING

Oxnard, California, 93036, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Fakultni Thomayerova nemocnice
RECRUITING

Prague, Praha 4, 14059, Czechia
Fakultni nemocnice v Motole
RECRUITING

Prague, Praha 5, 150 06, Czechia
Franciscus Vlietland Ziekenhuis
RECRUITING

Schiedam, South Holland, 3118 JH, Netherlands
Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, Fujian, 350001, China
Gangnam Severance Hospital, Yonsei University Health System
RECRUITING

Gangnam-gu, Seoul-teukbyeolsi [seoul], 06273, South Korea
Gunma Prefectural Cancer Center
RECRUITING

Otashi, Gunma, 373-8550, Japan
Hackensack University Medical Center
NOT_YET_RECRUITING

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Henry-Joyce Cancer Clinic
RECRUITING

Nashville, Tennessee, 37232, United States
Hospital Clínic de Barcelona
RECRUITING

Barcelona, Catalunya [cataluña], 08036, Spain
Hospital São Lucas da PUCRS
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario San Cecilio
RECRUITING

Granada, 18016, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Málaga, 29010, Spain
Hospital Universitario de Jaen
RECRUITING

Jaén, 23007, Spain
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410013, China
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Hygeia Hospital
RECRUITING

Marousi, Attikí, 151 23, Greece
Hôpital de la Croix-Rousse
NOT_YET_RECRUITING

Lyon, Rhône, 69004, France
IASO General Clinic
RECRUITING

Athens, Attica, 151 23, Greece
IBCC - Núcleo de Pesquisa e Ensino
NOT_YET_RECRUITING

São Paulo, 04014-002, Brazil
ICON Cancer Centre - Kurralta Park
NOT_YET_RECRUITING

Kurralta Park, South Australia, 5037, Australia
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Institut Bergonié
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Jules Bordet
RECRUITING

Anderlecht, Bruxelles-capitale, Région de, 1070, Belgium
Institut Régional du Cancer Montpellier
NOT_YET_RECRUITING

Montpellier, Hérault, 34298, France
Institut de Cancérologie de Lorraine Alexis Vautrin
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, Lorraine, 54519, France
Ironwood Cancer & Research Centers
RECRUITING

Chandler, Arizona, 85224, United States
Ironwood Cancer & Research Centers
RECRUITING

Gilbert, Arizona, 85297, United States
Ironwood Cancer & Research Centers
RECRUITING

Glendale, Arizona, 85306, United States
Ironwood Cancer & Research Centers
RECRUITING

Goodyear, Arizona, 85395, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85202, United States
Ironwood Cancer & Research Centers
RECRUITING

Mesa, Arizona, 85206, United States
Ironwood Cancer & Research Centers
RECRUITING

Phoenix, Arizona, 85028, United States
Ironwood Cancer & Research Centers
RECRUITING

Scottsdale, Arizona, 85260, United States
Istituto Nazionale dei Tumori IRCCS Fondazione G Pascale
NOT_YET_RECRUITING

Naples, Naples, 80131, Italy
Juntendo University Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 2418515, Japan
Kuopion Yliopistollinen Sairaala
RECRUITING

Kuopio, Northern Savonia, 70210, Finland
Los Angeles Cancer Network - (Admin Only / Central IDS) - No Patients
NOT_YET_RECRUITING

Glendale, California, 91204, United States
Los Angeles Cancer Network - Good Samaritan
NOT_YET_RECRUITING

Los Angeles, California, 90017, United States
Los Angeles Hematology Oncology Medical Group
NOT_YET_RECRUITING

Los Angeles, California, 90017, United States
MD Anderson League City
RECRUITING

League City, Texas, 77573, United States
MD Anderson West Houston
RECRUITING

Houston, Texas, 77079, United States
Mammazentrum HH am Krankenhaus Jerusalem
NOT_YET_RECRUITING

Hamburg, 20357, Germany
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Annapolis, Maryland, 21401, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Bethesda, Maryland, 20817, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Columbia, Maryland, 21044, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Germantown, Maryland, 20876, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Largo, Maryland, 20774, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Rockville, Maryland, 20850, United States
Maryland Oncology Hematology P.A.
NOT_YET_RECRUITING

Silver Spring, Maryland, 20904, United States
MedStar Washington Hospital Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medipol Mega Universite Hastanesi
RECRUITING

Istanbul, İ̇stanbul, 34214, Turkey (Türkiye)
Memorial Ankara Hastanesi
RECRUITING

Ankara, 06520, Turkey (Türkiye)
Memorial Hospital.
RECRUITING

Shiloh, Illinois, 62269, United States
Mfsmc-Hjwci
NOT_YET_RECRUITING

Baltimore, Maryland, 21237, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Coon Rapids, Minnesota, 55433, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Edina, Minnesota, 55435, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Maple Grove, Minnesota, 55369, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55404, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Plymouth, Minnesota, 55441, United States
Minnesota Oncology Hematology, P.A.
NOT_YET_RECRUITING

Woodbury, Minnesota, 55125, United States
Multiprofile Hospital for Active Treatment Serdikamed EOOD
RECRUITING

Sofia, Sofia (stolitsa), 1632, Bulgaria
Musgrove Park Hospital
NOT_YET_RECRUITING

Taunton, Somerset, TA1 5DA, United Kingdom
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
RECRUITING

Nanjing, Jiangsu, 210031, China
Narodny onkologicky ustav
RECRUITING

Bratislava, 833 10, Slovakia
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
Nemocnice AGEL Novy Jicin a.s.
RECRUITING

Nový Jičín, 741 01, Czechia
Nirmal Hospital Pvt Ltd.
RECRUITING

Surat, Gujarat, 395002, India
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
RECRUITING

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Onkologicky Ustav sv. Alzbety
RECRUITING

Bratislava, Bratislava Region, 812 50, Slovakia
Orchard Healthcare Research Inc.
NOT_YET_RECRUITING

Skokie, Illinois, 60077, United States
Osi Bilbao-Basurto
RECRUITING

Bilbao, Basque Country, 48013, Spain
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rambam Health Care Campus
RECRUITING

Haifa, Northern District, 3109601, Israel
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Colorado Springs, Colorado, 80923, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Longmont, Colorado, 80504, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Pueblo, Colorado, 81003, United States
Rocky Mountain Cancer Centers LLP
NOT_YET_RECRUITING

Thornton, Colorado, 80260, United States
Rolling Oaks Radiology - Oxnard
NOT_YET_RECRUITING

Oxnard, California, 93030, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, SE-41345, Sweden
Sahyadri Super Speciality Hospital
NOT_YET_RECRUITING

Pune, Maharashtra, 411004, India
Saint Luke's Hospital of Kansas City
NOT_YET_RECRUITING

Kansas City, Missouri, 64111, United States
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 06351, South Korea
Semmelweis Egyetem
NOT_YET_RECRUITING

Budapest, 1082, Hungary
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Kyǒnggi-do, 13620, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03722, South Korea
Shaare Zedek Medical Center
RECRUITING

Jerusalem, Jerusalem, 9013102, Israel
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Showa Medical University Hospital
RECRUITING

Tokyo, 142-8666, Japan
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States
Siteman Cancer Center - North County
RECRUITING

Florissant, Missouri, 63031, United States
Siteman Cancer Center - St Peters
RECRUITING

City of Saint Peters, Missouri, 63376, United States
Smilow Cancer Hospital - Derby
RECRUITING

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital - Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital - Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital - Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital - Long Ridge
RECRUITING

Stamford, Connecticut, 06902, United States
Smilow Cancer Hospital - North Haven
RECRUITING

North Haven, Connecticut, 06473, United States
Smilow Cancer Hospital - Waterbury
RECRUITING

Waterbury, Connecticut, 06708, United States
Smilow Cancer Hospital - Yale New Haven Health
RECRUITING

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States
Sourasky Medical Center
NOT_YET_RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Southern Medical University Nanfang Hospital
RECRUITING

Guangzhou, Guangdong, 510515, China
Spandana Oncology Centre (SOC)
RECRUITING

Bengaluru, Karnataka, 560069, India
Specialized Hospital for Active Treatment of Oncology - Haskovo
RECRUITING

Haskovo, 6300, Bulgaria
Summit Cancer Care
RECRUITING

Savannah, Georgia, 31405, United States
Summit Cancer Care, PC
RECRUITING

Savannah, Georgia, 31405, United States
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
Södersjukhuset
RECRUITING

Stockholm, Stockholms LÄN [se-01], 11883, Sweden
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tampereen yliopistollinen sairaala
RECRUITING

Tampere, Pirkanmaa, 33520, Finland
Texas Oncology - Central South (Balcones Dr)
RECRUITING

Austin, Texas, 78731, United States
Texas Oncology - Central South (James Casey)
RECRUITING

Austin, Texas, 78745, United States
Texas Oncology - Central South (South 2nd)
RECRUITING

McAllen, Texas, 78503, United States
Texas Oncology-Northeast Texas
RECRUITING

Allen, Texas, 75013, United States
Texas Oncology-Northeast Texas
RECRUITING

Denison, Texas, 75020, United States
Texas Oncology-Northeast Texas
RECRUITING

Denton, Texas, 76201, United States
Texas Oncology-Northeast Texas
RECRUITING

Flower Mound, Texas, 75028, United States
Texas Oncology-Northeast Texas
RECRUITING

Lewisville, Texas, 75056, United States
Texas Oncology-Northeast Texas
RECRUITING

Longview, Texas, 75601, United States
Texas Oncology-Northeast Texas
RECRUITING

McKinney, Texas, 75071, United States
Texas Oncology-Northeast Texas
RECRUITING

Palestine, Texas, 75801, United States
Texas Oncology-Northeast Texas
RECRUITING

Paris, Texas, 75460, United States
Texas Oncology-Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
The 2nd Affiliated Hospital of Dalian Medical University
RECRUITING

Dalian, Liaoning, 116023, China
The Cancer & Hematology Centers
RECRUITING

Holland, Michigan, 49424, United States
The West Clinic, PLLC dba West Cancer Center
NOT_YET_RECRUITING

Germantown, Tennessee, 38138, United States
Tokai University Hospital
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430030, China
US Oncology Investigational Product Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Products Center
RECRUITING

Irving, Texas, 75063, United States
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
University General Hospital of Heraklion
RECRUITING

Heraklion, Irakleío, 71500, Greece
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universitätsklinik Ulm
NOT_YET_RECRUITING

Ulm, Baden-Wurttemberg, 89075, Germany
Ventura County Hematology Oncology Specialists
NOT_YET_RECRUITING

Camarillo, California, 93010, United States
Ventura County Hematology Oncology Specialists
NOT_YET_RECRUITING

Oxnard, California, 93030, United States
Ventura County Hematology Oncology Specialists
NOT_YET_RECRUITING

Ventura, California, 93003, United States
Virginia Cancer Specialists
NOT_YET_RECRUITING

Manassas, Virginia, 20110, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Reston, Virginia, 20190, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Chesapeake, Virginia, 23320, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Virginia Beach, Virginia, 23456, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Williamsburg, Virginia, 23188, United States
Vychodoslovensky Onkologicky ustav a.s.
RECRUITING

Košice, Košice Region, 041 91, Slovakia
Western Health-Sunshine & Footscray Hospitals
RECRUITING

St Albans, Victoria, 3021, Australia

Conditions

Explore the condition pages connected to this study.

BREAST CANCER