New combo drug trial aims to tame aggressive blood cancers
NCT ID NCT03268954
Summary
This large, completed study tested if adding a new drug called pevonedistat to the standard treatment (azacitidine) could better control certain aggressive blood cancers. It involved 454 adults with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blast acute myeloid leukemia. The main goal was to see if the combination could delay death or the cancer worsening compared to the standard treatment alone.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia - INCIPIT - PIN
Brescia, Lombardy, 25123, Italy
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AZ Sint-Jan AV
Bruges, West-Vlaanderen, 8000, Belgium
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Algemeen Ziekenhuis Klina
Brasschaat, Antwerpen, 2930, Belgium
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Arizona Oncology Associates (Orange HOPE) - USOR
Tucson, Arizona, 85704, United States
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Arizona Oncology Associates (Rudasill HOPE) - USOR
Tucson, Arizona, 85704, United States
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Arizona Oncology Associates (Wilmot HOPE) - USOR
Tucson, Arizona, 85711, United States
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Asan Medical Center - PPDS
Seoul, 5505, South Korea
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Athens General Hospital 'G Gennimatas'
Athens, Attica, 11527, Greece
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Attikon University General Hospital
Athens, Attica, 12462, Greece
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Azienda Ospedaliera Universitaria Careggi
Florence, 50134, Italy
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Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi
Bologna, Emilia-Romagna, 40138, Italy
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Azienda Ospedaliero Universitaria San Giovanni Battista Di Torino
Torino, 10126, Italy
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Baptist Health System (N Kendall) - USOR
Miami, Florida, 33176, United States
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Baylor Sammons Cancer Center
Dallas, Texas, 75246, United States
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CHU Angers
Angers, Maine-et-Loire, 49100, France
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CHU UCL Namur asbl - Site Godinne
Yvoir, Namur, 5530, Belgium
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Capital Humano para Investigacion Clinica SC
México, Mexico
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Centerpoint Medical Center
Independence, Missouri, 64057, United States
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Centre Hospitalier Le Mans
Le Mans, 74000, France
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Centro de Pesquisas Oncologicas
Florianópolis, Santa Catarina, 88034-000, Brazil
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Centrum Onkologii Ziemi Lubelskiej
Lublin, 20-090, Poland
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Chonnam National University Hwasun Hospital
Jeongnam, 58128, South Korea
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City Clinical Hospital # 40
Moscow, 129301, Russia
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
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Colorado Blood Cancer Institute - PPDS
Denver, Colorado, 80218, United States
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Compassionate Cancer Care Medical Group Inc
Fountain Valley, California, 92708, United States
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Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc
Corona, California, 92879, United States
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Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc
Riverside, California, 92501, United States
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Complejo Asistencial Universitario de Leon
León, Castille and León, 24071, Spain
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Complejo Asistencial Universitario de Salamanca - H. Clinico
Salamanca, 37007, Spain
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Dokkyo Medical University Hospital
Mibu, 321-0293, Japan
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Edith Wolfson Medical Center
Holon, 58100, Israel
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Ege University Medical Faculty
Izmir, 35100, Turkey (Türkiye)
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Emad Ibrahim, MD, Inc
Redlands, California, 92373, United States
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Fairview Hospital
Cleveland, Ohio, 44111, United States
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Fakultni nemocnice Hradec Kralove
Hradec Králové, Kralovehradeck Kraj, 500 05, Czechia
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Fakultni nemocnice Kralovske Vinohrady
Prague, 100 34, Czechia
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Altamonte Springs, Florida, 32701, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Brandon, Florida, 33511, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Clearwater, Florida, 33761, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Gainesville, Florida, 32605, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Largo, Florida, 33770, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Lecanto, Florida, 34461, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
New Port Richey, Florida, 34655, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Ocala, Florida, 34471, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Orange City, Florida, 32763, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Orlando, Florida, 32806, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Spring Hill, Florida, 34608, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
St. Petersburg, Florida, 33705, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Tampa, Florida, 33607, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Tavares, Florida, 32778, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
The Villages, Florida, 32159, United States
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Florida Cancer Specialists - NORTH - SCRI - PPDS
Winter Park, Florida, 32792, United States
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Fukushima Medical University Hospital
Fukushima, Hukusima, 960-1295, Japan
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Galilee Medical Center
Nahariya, Israel
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Gazi University Medical Faculty Gazi Hospital
Ankara, 6500, Turkey (Türkiye)
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Georgios Papanikolaou General Hospital of Thessaloniki
Thessaloniki, 57010, Greece
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Greenville Health System
Easley, South Carolina, 29640, United States
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Greenville Health System
Greenville, South Carolina, 29605, United States
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Greenville Health System
Greer, South Carolina, 29650, United States
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Greenville Health System
Seneca, South Carolina, 29672, United States
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Greenville Health System
Spartanburg, South Carolina, 29307, United States
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Greenville Health System Cancer Institute
Greenville, South Carolina, 29615, United States
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HCA Midwest Health - SCRI - PPDS
Kansas City, Missouri, 64132, United States
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Hadassah Medical Center PPDS -
Jerusalem, 91120, Israel
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Hematologica Alta Especialidad S.C.
Huixquilucan, 52787, Mexico
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Hillcrest Hospital Cancer Care Center
Mayfield, Ohio, 44124, United States
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Hokkaido University Hospital
Sapporo, Hokkaido, 060 8638, Japan
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Hopital Cote de Nacre
Caen, Calvados, 14033, France
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Hopital Saint Louis
Paris, 75010, France
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Hopital Saint Louis
Paris, 75475, France
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital General Universitario Gregorio Maranon
Madrid, 28009, Spain
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Hospital Santa Marcelina
São Paulo, 08270-120, Brazil
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Hospital Santa Marcelina
São Paulo, 08270-270, Brazil
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario La Paz - PPDS
Madrid, 28046, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Vall d'Hebron - PPDS
Barcelona, 8035, Spain
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Hospital Universitario de La Princesa
Madrid, 28006, Spain
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Hospital de Clinicas de Porto Alegre (HCPA) - PPDS
Porto Alegre, 90035-903, Brazil
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ICO lHospitalet Hospital Duran i Reynals
LHospitalet de Llobregat, Barcelona, 8907, Spain
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IRCCS Centro Di Riferimento Oncologico Della Basilicata
Rionero in Vulture, 85028, Italy
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Icon Cancer Care
South Brisbane, Queensland, 4101, Australia
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Icon Cancer Care Chermside
Chermside, Queensland, 4032, Australia
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Icon Cancer Care South Brisbane
South Brisbane, Queensland, 4101, Australia
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Icon Cancer Care Southport
Southport, Queensland, 4215, Australia
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Icon Cancer Care Wesley
Auchenflower, Queensland, 4066, Australia
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Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, 300020, China
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Instytut Hematologii i Transfuzjologii
Warsaw, Masovian Voivodeship, 02-776, Poland
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Istituto Clinico Humanitas
Rozzano, 20089, Italy
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Japan Mutual Aid Association of Public School Teachers Chugoku Central Hospital
Fukuyama, Hiroshima, 720-0001, Japan
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John Theurer Cancer Center
Hackensack, New Jersey, 07601, United States
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Juntendo University Hospital
Bunkyo, Tokyo, 113-8431, Japan
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Kaiser Foundation Health Plan
Denver, Colorado, 80239, United States
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Karadeniz Technical University Faculty of Medicine
Trabzon, 61080, Turkey (Türkiye)
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Kaye Edmonton Clinic
Edmonton, Alberta, T6G1Z1, Canada
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Kindai University Hospital
Sayama, Osaka, 589-8511, Japan
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Kobe City Medical Center General Hospital
Kobe, Hyōgo, 650-0047, Japan
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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Laboratory Corporation of America
Englewood, Colorado, 80112, United States
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Laiko General Hospital of Athens
Athens, Attica, 115 27, Greece
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Laiko General Hospital of Athens
Athens, 11527, Greece
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Liga Norte Riograndense Contra O Cancer
Natal, Rio Grande do Norte, 59075-740, Brazil
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Liga Paranaense de Combate Ao Cancer - Hospital Erasto Gaertner
Curitiba, Paraná, 81520-060, Brazil
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Liverpool Hospital
Liverpool, 1871, Australia
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Maidstone Hospital
Maidstone, Kent, ME16 9QQ, United Kingdom
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Marien Hospital Akademisches Lehrkrankenhaus
Düsseldorf, 40479, Germany
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Mayo Clinic Jacksonville - PPDS
Jacksonville, Florida, 32224, United States
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Medstar Research Institute
Washington D.C., District of Columbia, 20010, United States
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Menorah Medical Center
Overland Park, Kansas, 66209, United States
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Mersin University Medical Faculty
Mersin, 33343, Turkey (Türkiye)
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NTT Medical Center Tokyo
Shinagawa-ku, Tokyo, 141-8625, Japan
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Nagasaki University Hospital
Nagasaki, 8528102, Japan
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Namik Kemal University
Tekirdağ, 59100, Turkey (Türkiye)
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Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
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New Jersey Hematology Oncology Associates LLC
Brick, New Jersey, 08724, United States
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New Jersey Hematology and Oncology
Toms River, New Jersey, 08755, United States
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North-West Federal Medical Research Center n.a. V.A. Almazov
Saint Petersburg, 197341, Russia
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Oncology Hematology Care Inc - USOR
Cincinnati, Ohio, 45236, United States
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Oncology Hematology Care Inc - USOR
Cincinnati, Ohio, 45242, United States
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Oncology Hematology Care, Inc - Fairfield
Fairfield, Ohio, 45014, United States
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Oncology Hematology Care, Inc.
Cincinnati, Ohio, 45211, United States
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Oncology Hematology Care, Inc.
Cincinnati, Ohio, 45230, United States
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Oncology and Hematology Associates of Southwest Virginia
Wytheville, Virginia, 24382, United States
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Oncology and Hematology Associates of Southwest Virginia (Blacksburg) - USOR
Blacksburg, Virginia, 24060, United States
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Oncology and Hematology Associates of Southwest Virginia (Low Moor) - USOR
Low Moor, Virginia, 24457, United States
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Oncology and Hematology Associates of Southwest Virginia (Roanoke) - USOR
Roanoke, Virginia, 24014, United States
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Oncology and Hematology Associates of Southwest Virginia Inc
Salem, Virginia, 24153, United States
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Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun, 55139, Turkey (Türkiye)
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Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
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Presbyterian Saint Lukes Medical Center Laboratory
Denver, Colorado, 80218, United States
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Presbyterian/St. Luke's Medical Center
Denver, Colorado, 80218, United States
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Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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Princess Margaret Hospital
Toronto, Ontario, M5G2M9, Canada
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Pusan National University Hospital
Busan, 49241, South Korea
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Quest Diagnostics, INC
Denver, Colorado, 80209, United States
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Research Medical Center
Kansas City, Missouri, 64132, United States
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Rocky Mountain Cancer Centers (Aurora) - USOR
Aurora, Colorado, 80012, United States
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Rocky Mountain Cancer Centers (Boulder) - USOR
Boulder, Colorado, 80303, United States
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Rocky Mountain Cancer Centers (Colorado Springs) - USOR
Colorado Springs, Colorado, 80907, United States
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Rocky Mountain Cancer Centers (Denver) - USOR
Denver, Colorado, 80220, United States
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Rocky Mountain Cancer Centers (Lakewood) - USOR
Lakewood, Colorado, 80228, United States
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Rocky Mountain Cancer Centers (Littleton) - USOR
Littleton, Colorado, 80120, United States
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Rocky Mountain Cancer Centers (Lone Tree) - USOR
Lone Tree, Colorado, 80124, United States
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Rocky Mountain Cancer Centers (Longmont) - USOR
Longmont, Colorado, 80501, United States
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Rocky Mountain Cancer Centers (Parker) - USOR
Parker, Colorado, 80138, United States
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Rocky Mountain Cancer Centers (Pueblo) - USOR
Pueblo, Colorado, 81008, United States
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Rocky Mountain Cancer Centers (Thornton) - USOR
Thornton, Colorado, 80260, United States
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Rocky Mountain Cancer Centers (Williams) - USOR
Denver, Colorado, 80218, United States
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Royal Bournemouth Hospital
Bournemouth, Dorset, BH7 7DW, United Kingdom
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Royal Hobart Hospital
Hobart, Tasmania, 7000, Australia
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Russian Research Institute of Hematology and Blood Transfusion
Saint Petersburg, 191024, Russia
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SCRI Florida Cancer Specialists South
Bonita Springs, Florida, 34135, United States
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SCRI Florida Cancer Specialists South
Bradenton, Florida, 34209, United States
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SCRI Florida Cancer Specialists South
Cape Coral, Florida, 33914, United States
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SCRI Florida Cancer Specialists South
Fort Myers, Florida, 33905, United States
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SCRI Florida Cancer Specialists South
Fort Myers, Florida, 33908, United States
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SCRI Florida Cancer Specialists South
Fort Myers, Florida, 33916, United States
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SCRI Florida Cancer Specialists South
Naples, Florida, 34102, United States
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SCRI Florida Cancer Specialists South
Port Charlotte, Florida, 33980, United States
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SCRI Florida Cancer Specialists South
Sarasota, Florida, 34232, United States
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SCRI Florida Cancer Specialists South
Sarasota, Florida, 34236, United States
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SCRI Florida Cancer Specialists South
Venice, Florida, 34285, United States
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SCRI Florida Cancer Specialists South
Venice, Florida, 34292, United States
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Saint Alphonsus Caldwell Cancer Care Center
Caldwell, Idaho, 83605, United States
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Saint Alphonsus Medical Center
Nampa, Idaho, 83687, United States
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Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
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Saint John Regional Hospital
Saint John, New Brunswick, E2L 4L2, Canada
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Saitama Medical Center
Kawagoe, Saitama, 3508550, Japan
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Samsung Medical Center - PPDS
Seoul, 6351, South Korea
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Sarah Cannon Center for Blood Centers - SCRI - PPDS
Nashville, Tennessee, 37203, United States
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Shaare Zedek Medical Center
Jerusalem, 91031, Israel
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Singleton Hospital - PPDS
Swansea, SA2 8QA, United Kingdom
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Southeastern Regional Medical Center - CTCA - PPDS
Goodyear, Arizona, 85338, United States
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Southern Cancer Center - USOR
Daphne, Alabama, 36526, United States
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Southern Cancer Center - USOR
Mobile, Alabama, 36607, United States
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Southern Cancer Center - USOR
Mobile, Alabama, 36608, United States
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Southern Cancer Center- USOR
Mobile, Alabama, 36608, United States
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St Bartholomew's Hospital
London, EC1A 7BE, United Kingdom
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St. Luke's Hospital
Bethlehem, Pennsylvania, 18015, United States
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St. Luke's University Health Network
Easton, Pennsylvania, 18045, United States
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Strong Memorial Hospital
Rochester, New York, 14642, United States
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Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N3M5, Canada
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Swietokrzyskie Centrum Onkologii
Kielce, Świętokrzyskie Voivodeship, 25-734, Poland
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Szpital Wojewodzki w Opolu
Opole, 45-372, Poland
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Tel Aviv Sourasky Medical Center PPDS
Tel Aviv, 64239, Israel
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Tennessee Oncolgy - BAPTIST - SCRI - PPDS
Nashville, Tennessee, 37203, United States
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Tennessee Oncology - DICKSON - SCRI - PPDS
Dickson, Tennessee, 37055, United States
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Tennessee Oncology - FRANKLIN - SCRI - PPDS
Franklin, Tennessee, 37067, United States
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Tennessee Oncology - GALLATIN - SCRI - PPDS
Gallatin, Tennessee, 37066, United States
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Tennessee Oncology - LEBANON - SCRI - PPDS
Lebanon, Tennessee, 37090, United States
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Tennessee Oncology - MURFREESBORO - SCRI - PPDS
Murfreesboro, Tennessee, 37129, United States
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Tennessee Oncology - SHELBYVILLE - SCRI - PPDS
Shelbyville, Tennessee, 37160, United States
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Tennessee Oncology - SMYRNA - SCRI - PPDS
Smyrna, Tennessee, 37167, United States
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Tennessee Oncology - SOUTHERN HILLS - SCRI - PPDS
Nashville, Tennessee, 37211, United States
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Tennessee Oncology - ST THOMAS WEST - SCRI - PPDS
Nashville, Tennessee, 37205, United States
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Tennessee Oncology - SUMMIT - SCRI - PPDS
Hermitage, Tennessee, 37076, United States
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Tennessee Oncology NASH - SCRI - PPDS
Nashville, Tennessee, 37203, United States
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Tennessee Oncology SKYLINE - SCRI - PPDS
Nashville, Tennessee, 37207, United States
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Texas Oncology (Balcones) - USOR
Austin, Texas, 78731, United States
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Texas Oncology (E Common) - USOR
New Braunfels, Texas, 78130, United States
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Texas Oncology (James Casey) - USOR
Austin, Texas, 78745, United States
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Texas Oncology (Medical City) - USOR
Dallas, Texas, 75230, United States
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Texas Oncology (Round Rock) - USOR
Round Rock, Texas, 78681, United States
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Texas Oncology (Tyler) - USOR
Longview, Texas, 75601, United States
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Texas Oncology (Tyler) - USOR
Tyler, Texas, 75702, United States
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Texas Oncology (West 38) - USOR
Austin, Texas, 78705, United States
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Texas Oncology - San Antonio Medical Center - USOR
San Antonio, Texas, 78240, United States
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 6591, South Korea
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Tom Baker Cancer Centre
Calgary, Alberta, T2N 4, Canada
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UZ Leuven
Leuven, 3000, Belgium
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Universidade Federal do Rio de Janeiro - UFRJ
Rio de Janeiro, 21941-913, Brazil
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Universitatsklinikum Carl Gustav Carus an der TU Dresden
Dresden, 1307, Germany
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Universitatsklinikum Leipzig
Leipzig, Saxony, 4103, Germany
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Universitatsklinikum Tubingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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University General Hospital of Ioannina
Ioannina, 45500, Greece
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University General Hospital of Larissa
Larissa, 41110, Greece
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University General Hospital of Patras
Pátrai, 26504, Greece
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University Hospital of Alexandroupolis
Alexandroupoli, 68100, Greece
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University Hospital, Kyoto Prefectural University of Medicine
Kyoto, Kyoto, 602-8566, Japan
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University of Alberta
Edmonton, Alberta, T6G 2B7, Canada
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University of Fukui Hospital
Yoshida-gun, 910-1193, Japan
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University of Miami Miller School of Medicine
Miami, Florida, 33136, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Virginia
Charlottesville, Virginia, 22903, United States
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Uniwersyteckie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, 80-952, Poland
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Uniwersyteckie Centrum Kliniczne, Klinika Hematologii I Transplantologii, Budynek Centrum Medycyny N
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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Vseobecna Fakultni Nemocnice V Praze
Prague, 128 08, Czechia
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Weill Cornell Medical Center
New York, New York, 10021, United States
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Weill Cornell Medical Center - Monitoring Location
New York, New York, 10021, United States
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Winship Cancer Institute, Emory University
Atlanta, Georgia, 30322, United States
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Xuanwu Hospital Capital Medical University
Beijing, Beijing Municipality, 100053, China
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Yokohama City University Hospital
Yokohama, 232-0024, Japan
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ZIV Medical Center
Safed, 13100, Israel
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Zaklad Diagnostyki Obrazowej SOR
Opole, 45-061, Poland
Conditions
Explore the condition pages connected to this study.