New combo drug trial aims to tame aggressive blood cancers

NCT ID NCT03268954

Summary

This large, completed study tested if adding a new drug called pevonedistat to the standard treatment (azacitidine) could better control certain aggressive blood cancers. It involved 454 adults with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or low-blast acute myeloid leukemia. The main goal was to see if the combination could delay death or the cancer worsening compared to the standard treatment alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia - INCIPIT - PIN

    Brescia, Lombardy, 25123, Italy

  • AZ Sint-Jan AV

    Bruges, West-Vlaanderen, 8000, Belgium

  • Algemeen Ziekenhuis Klina

    Brasschaat, Antwerpen, 2930, Belgium

  • Arizona Oncology Associates (Orange HOPE) - USOR

    Tucson, Arizona, 85704, United States

  • Arizona Oncology Associates (Rudasill HOPE) - USOR

    Tucson, Arizona, 85704, United States

  • Arizona Oncology Associates (Wilmot HOPE) - USOR

    Tucson, Arizona, 85711, United States

  • Asan Medical Center - PPDS

    Seoul, 5505, South Korea

  • Athens General Hospital 'G Gennimatas'

    Athens, Attica, 11527, Greece

  • Attikon University General Hospital

    Athens, Attica, 12462, Greece

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi

    Bologna, Emilia-Romagna, 40138, Italy

  • Azienda Ospedaliero Universitaria San Giovanni Battista Di Torino

    Torino, 10126, Italy

  • Baptist Health System (N Kendall) - USOR

    Miami, Florida, 33176, United States

  • Baylor Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • CHU Angers

    Angers, Maine-et-Loire, 49100, France

  • CHU UCL Namur asbl - Site Godinne

    Yvoir, Namur, 5530, Belgium

  • Capital Humano para Investigacion Clinica SC

    México, Mexico

  • Centerpoint Medical Center

    Independence, Missouri, 64057, United States

  • Centre Hospitalier Le Mans

    Le Mans, 74000, France

  • Centro de Pesquisas Oncologicas

    Florianópolis, Santa Catarina, 88034-000, Brazil

  • Centrum Onkologii Ziemi Lubelskiej

    Lublin, 20-090, Poland

  • Chonnam National University Hwasun Hospital

    Jeongnam, 58128, South Korea

  • City Clinical Hospital # 40

    Moscow, 129301, Russia

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Colorado Blood Cancer Institute - PPDS

    Denver, Colorado, 80218, United States

  • Compassionate Cancer Care Medical Group Inc

    Fountain Valley, California, 92708, United States

  • Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc

    Corona, California, 92879, United States

  • Compassionate Care Research Group Inc. at Compassionate Cancer Care Medical Group, Inc

    Riverside, California, 92501, United States

  • Complejo Asistencial Universitario de Leon

    León, Castille and León, 24071, Spain

  • Complejo Asistencial Universitario de Salamanca - H. Clinico

    Salamanca, 37007, Spain

  • Dokkyo Medical University Hospital

    Mibu, 321-0293, Japan

  • Edith Wolfson Medical Center

    Holon, 58100, Israel

  • Ege University Medical Faculty

    Izmir, 35100, Turkey (Türkiye)

  • Emad Ibrahim, MD, Inc

    Redlands, California, 92373, United States

  • Fairview Hospital

    Cleveland, Ohio, 44111, United States

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, Kralovehradeck Kraj, 500 05, Czechia

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Altamonte Springs, Florida, 32701, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Brandon, Florida, 33511, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Clearwater, Florida, 33761, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Gainesville, Florida, 32605, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Largo, Florida, 33770, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Lecanto, Florida, 34461, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    New Port Richey, Florida, 34655, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Ocala, Florida, 34471, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Orange City, Florida, 32763, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Orlando, Florida, 32806, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Spring Hill, Florida, 34608, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Tampa, Florida, 33607, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Tavares, Florida, 32778, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    The Villages, Florida, 32159, United States

  • Florida Cancer Specialists - NORTH - SCRI - PPDS

    Winter Park, Florida, 32792, United States

  • Fukushima Medical University Hospital

    Fukushima, Hukusima, 960-1295, Japan

  • Galilee Medical Center

    Nahariya, Israel

  • Gazi University Medical Faculty Gazi Hospital

    Ankara, 6500, Turkey (Türkiye)

  • Georgios Papanikolaou General Hospital of Thessaloniki

    Thessaloniki, 57010, Greece

  • Greenville Health System

    Easley, South Carolina, 29640, United States

  • Greenville Health System

    Greenville, South Carolina, 29605, United States

  • Greenville Health System

    Greer, South Carolina, 29650, United States

  • Greenville Health System

    Seneca, South Carolina, 29672, United States

  • Greenville Health System

    Spartanburg, South Carolina, 29307, United States

  • Greenville Health System Cancer Institute

    Greenville, South Carolina, 29615, United States

  • HCA Midwest Health - SCRI - PPDS

    Kansas City, Missouri, 64132, United States

  • Hadassah Medical Center PPDS -

    Jerusalem, 91120, Israel

  • Hematologica Alta Especialidad S.C.

    Huixquilucan, 52787, Mexico

  • Hillcrest Hospital Cancer Care Center

    Mayfield, Ohio, 44124, United States

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060 8638, Japan

  • Hopital Cote de Nacre

    Caen, Calvados, 14033, France

  • Hopital Saint Louis

    Paris, 75010, France

  • Hopital Saint Louis

    Paris, 75475, France

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28009, Spain

  • Hospital Santa Marcelina

    São Paulo, 08270-120, Brazil

  • Hospital Santa Marcelina

    São Paulo, 08270-270, Brazil

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario La Paz - PPDS

    Madrid, 28046, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 8035, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de Clinicas de Porto Alegre (HCPA) - PPDS

    Porto Alegre, 90035-903, Brazil

  • ICO lHospitalet Hospital Duran i Reynals

    LHospitalet de Llobregat, Barcelona, 8907, Spain

  • IRCCS Centro Di Riferimento Oncologico Della Basilicata

    Rionero in Vulture, 85028, Italy

  • Icon Cancer Care

    South Brisbane, Queensland, 4101, Australia

  • Icon Cancer Care Chermside

    Chermside, Queensland, 4032, Australia

  • Icon Cancer Care South Brisbane

    South Brisbane, Queensland, 4101, Australia

  • Icon Cancer Care Southport

    Southport, Queensland, 4215, Australia

  • Icon Cancer Care Wesley

    Auchenflower, Queensland, 4066, Australia

  • Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences

    Tianjin, Tianjin Municipality, 300020, China

  • Instytut Hematologii i Transfuzjologii

    Warsaw, Masovian Voivodeship, 02-776, Poland

  • Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Japan Mutual Aid Association of Public School Teachers Chugoku Central Hospital

    Fukuyama, Hiroshima, 720-0001, Japan

  • John Theurer Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Juntendo University Hospital

    Bunkyo, Tokyo, 113-8431, Japan

  • Kaiser Foundation Health Plan

    Denver, Colorado, 80239, United States

  • Karadeniz Technical University Faculty of Medicine

    Trabzon, 61080, Turkey (Türkiye)

  • Kaye Edmonton Clinic

    Edmonton, Alberta, T6G1Z1, Canada

  • Kindai University Hospital

    Sayama, Osaka, 589-8511, Japan

  • Kobe City Medical Center General Hospital

    Kobe, Hyōgo, 650-0047, Japan

  • Kyungpook National University Hospital

    Daegu, 41944, South Korea

  • Kyushu University Hospital

    Fukuoka, 812-8582, Japan

  • Laboratory Corporation of America

    Englewood, Colorado, 80112, United States

  • Laiko General Hospital of Athens

    Athens, Attica, 115 27, Greece

  • Laiko General Hospital of Athens

    Athens, 11527, Greece

  • Liga Norte Riograndense Contra O Cancer

    Natal, Rio Grande do Norte, 59075-740, Brazil

  • Liga Paranaense de Combate Ao Cancer - Hospital Erasto Gaertner

    Curitiba, Paraná, 81520-060, Brazil

  • Liverpool Hospital

    Liverpool, 1871, Australia

  • Maidstone Hospital

    Maidstone, Kent, ME16 9QQ, United Kingdom

  • Marien Hospital Akademisches Lehrkrankenhaus

    Düsseldorf, 40479, Germany

  • Mayo Clinic Jacksonville - PPDS

    Jacksonville, Florida, 32224, United States

  • Medstar Research Institute

    Washington D.C., District of Columbia, 20010, United States

  • Menorah Medical Center

    Overland Park, Kansas, 66209, United States

  • Mersin University Medical Faculty

    Mersin, 33343, Turkey (Türkiye)

  • NTT Medical Center Tokyo

    Shinagawa-ku, Tokyo, 141-8625, Japan

  • Nagasaki University Hospital

    Nagasaki, 8528102, Japan

  • Namik Kemal University

    Tekirdağ, 59100, Turkey (Türkiye)

  • Nebraska Cancer Specialists

    Omaha, Nebraska, 68130, United States

  • New Jersey Hematology Oncology Associates LLC

    Brick, New Jersey, 08724, United States

  • New Jersey Hematology and Oncology

    Toms River, New Jersey, 08755, United States

  • North-West Federal Medical Research Center n.a. V.A. Almazov

    Saint Petersburg, 197341, Russia

  • Oncology Hematology Care Inc - USOR

    Cincinnati, Ohio, 45236, United States

  • Oncology Hematology Care Inc - USOR

    Cincinnati, Ohio, 45242, United States

  • Oncology Hematology Care, Inc - Fairfield

    Fairfield, Ohio, 45014, United States

  • Oncology Hematology Care, Inc.

    Cincinnati, Ohio, 45211, United States

  • Oncology Hematology Care, Inc.

    Cincinnati, Ohio, 45230, United States

  • Oncology and Hematology Associates of Southwest Virginia

    Wytheville, Virginia, 24382, United States

  • Oncology and Hematology Associates of Southwest Virginia (Blacksburg) - USOR

    Blacksburg, Virginia, 24060, United States

  • Oncology and Hematology Associates of Southwest Virginia (Low Moor) - USOR

    Low Moor, Virginia, 24457, United States

  • Oncology and Hematology Associates of Southwest Virginia (Roanoke) - USOR

    Roanoke, Virginia, 24014, United States

  • Oncology and Hematology Associates of Southwest Virginia Inc

    Salem, Virginia, 24153, United States

  • Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi

    Samsun, 55139, Turkey (Türkiye)

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586, Japan

  • Presbyterian Saint Lukes Medical Center Laboratory

    Denver, Colorado, 80218, United States

  • Presbyterian/St. Luke's Medical Center

    Denver, Colorado, 80218, United States

  • Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • Princess Margaret Hospital

    Toronto, Ontario, M5G2M9, Canada

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Quest Diagnostics, INC

    Denver, Colorado, 80209, United States

  • Research Medical Center

    Kansas City, Missouri, 64132, United States

  • Rocky Mountain Cancer Centers (Aurora) - USOR

    Aurora, Colorado, 80012, United States

  • Rocky Mountain Cancer Centers (Boulder) - USOR

    Boulder, Colorado, 80303, United States

  • Rocky Mountain Cancer Centers (Colorado Springs) - USOR

    Colorado Springs, Colorado, 80907, United States

  • Rocky Mountain Cancer Centers (Denver) - USOR

    Denver, Colorado, 80220, United States

  • Rocky Mountain Cancer Centers (Lakewood) - USOR

    Lakewood, Colorado, 80228, United States

  • Rocky Mountain Cancer Centers (Littleton) - USOR

    Littleton, Colorado, 80120, United States

  • Rocky Mountain Cancer Centers (Lone Tree) - USOR

    Lone Tree, Colorado, 80124, United States

  • Rocky Mountain Cancer Centers (Longmont) - USOR

    Longmont, Colorado, 80501, United States

  • Rocky Mountain Cancer Centers (Parker) - USOR

    Parker, Colorado, 80138, United States

  • Rocky Mountain Cancer Centers (Pueblo) - USOR

    Pueblo, Colorado, 81008, United States

  • Rocky Mountain Cancer Centers (Thornton) - USOR

    Thornton, Colorado, 80260, United States

  • Rocky Mountain Cancer Centers (Williams) - USOR

    Denver, Colorado, 80218, United States

  • Royal Bournemouth Hospital

    Bournemouth, Dorset, BH7 7DW, United Kingdom

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Russian Research Institute of Hematology and Blood Transfusion

    Saint Petersburg, 191024, Russia

  • SCRI Florida Cancer Specialists South

    Bonita Springs, Florida, 34135, United States

  • SCRI Florida Cancer Specialists South

    Bradenton, Florida, 34209, United States

  • SCRI Florida Cancer Specialists South

    Cape Coral, Florida, 33914, United States

  • SCRI Florida Cancer Specialists South

    Fort Myers, Florida, 33905, United States

  • SCRI Florida Cancer Specialists South

    Fort Myers, Florida, 33908, United States

  • SCRI Florida Cancer Specialists South

    Fort Myers, Florida, 33916, United States

  • SCRI Florida Cancer Specialists South

    Naples, Florida, 34102, United States

  • SCRI Florida Cancer Specialists South

    Port Charlotte, Florida, 33980, United States

  • SCRI Florida Cancer Specialists South

    Sarasota, Florida, 34232, United States

  • SCRI Florida Cancer Specialists South

    Sarasota, Florida, 34236, United States

  • SCRI Florida Cancer Specialists South

    Venice, Florida, 34285, United States

  • SCRI Florida Cancer Specialists South

    Venice, Florida, 34292, United States

  • Saint Alphonsus Caldwell Cancer Care Center

    Caldwell, Idaho, 83605, United States

  • Saint Alphonsus Medical Center

    Nampa, Idaho, 83687, United States

  • Saint Alphonsus Regional Medical Center

    Boise, Idaho, 83706, United States

  • Saint John Regional Hospital

    Saint John, New Brunswick, E2L 4L2, Canada

  • Saitama Medical Center

    Kawagoe, Saitama, 3508550, Japan

  • Samsung Medical Center - PPDS

    Seoul, 6351, South Korea

  • Sarah Cannon Center for Blood Centers - SCRI - PPDS

    Nashville, Tennessee, 37203, United States

  • Shaare Zedek Medical Center

    Jerusalem, 91031, Israel

  • Singleton Hospital - PPDS

    Swansea, SA2 8QA, United Kingdom

  • Southeastern Regional Medical Center - CTCA - PPDS

    Goodyear, Arizona, 85338, United States

  • Southern Cancer Center - USOR

    Daphne, Alabama, 36526, United States

  • Southern Cancer Center - USOR

    Mobile, Alabama, 36607, United States

  • Southern Cancer Center - USOR

    Mobile, Alabama, 36608, United States

  • Southern Cancer Center- USOR

    Mobile, Alabama, 36608, United States

  • St Bartholomew's Hospital

    London, EC1A 7BE, United Kingdom

  • St. Luke's Hospital

    Bethlehem, Pennsylvania, 18015, United States

  • St. Luke's University Health Network

    Easton, Pennsylvania, 18045, United States

  • Strong Memorial Hospital

    Rochester, New York, 14642, United States

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N3M5, Canada

  • Swietokrzyskie Centrum Onkologii

    Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

  • Szpital Wojewodzki w Opolu

    Opole, 45-372, Poland

  • Tel Aviv Sourasky Medical Center PPDS

    Tel Aviv, 64239, Israel

  • Tennessee Oncolgy - BAPTIST - SCRI - PPDS

    Nashville, Tennessee, 37203, United States

  • Tennessee Oncology - DICKSON - SCRI - PPDS

    Dickson, Tennessee, 37055, United States

  • Tennessee Oncology - FRANKLIN - SCRI - PPDS

    Franklin, Tennessee, 37067, United States

  • Tennessee Oncology - GALLATIN - SCRI - PPDS

    Gallatin, Tennessee, 37066, United States

  • Tennessee Oncology - LEBANON - SCRI - PPDS

    Lebanon, Tennessee, 37090, United States

  • Tennessee Oncology - MURFREESBORO - SCRI - PPDS

    Murfreesboro, Tennessee, 37129, United States

  • Tennessee Oncology - SHELBYVILLE - SCRI - PPDS

    Shelbyville, Tennessee, 37160, United States

  • Tennessee Oncology - SMYRNA - SCRI - PPDS

    Smyrna, Tennessee, 37167, United States

  • Tennessee Oncology - SOUTHERN HILLS - SCRI - PPDS

    Nashville, Tennessee, 37211, United States

  • Tennessee Oncology - ST THOMAS WEST - SCRI - PPDS

    Nashville, Tennessee, 37205, United States

  • Tennessee Oncology - SUMMIT - SCRI - PPDS

    Hermitage, Tennessee, 37076, United States

  • Tennessee Oncology NASH - SCRI - PPDS

    Nashville, Tennessee, 37203, United States

  • Tennessee Oncology SKYLINE - SCRI - PPDS

    Nashville, Tennessee, 37207, United States

  • Texas Oncology (Balcones) - USOR

    Austin, Texas, 78731, United States

  • Texas Oncology (E Common) - USOR

    New Braunfels, Texas, 78130, United States

  • Texas Oncology (James Casey) - USOR

    Austin, Texas, 78745, United States

  • Texas Oncology (Medical City) - USOR

    Dallas, Texas, 75230, United States

  • Texas Oncology (Round Rock) - USOR

    Round Rock, Texas, 78681, United States

  • Texas Oncology (Tyler) - USOR

    Longview, Texas, 75601, United States

  • Texas Oncology (Tyler) - USOR

    Tyler, Texas, 75702, United States

  • Texas Oncology (West 38) - USOR

    Austin, Texas, 78705, United States

  • Texas Oncology - San Antonio Medical Center - USOR

    San Antonio, Texas, 78240, United States

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 6591, South Korea

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N 4, Canada

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universidade Federal do Rio de Janeiro - UFRJ

    Rio de Janeiro, 21941-913, Brazil

  • Universitatsklinikum Carl Gustav Carus an der TU Dresden

    Dresden, 1307, Germany

  • Universitatsklinikum Leipzig

    Leipzig, Saxony, 4103, Germany

  • Universitatsklinikum Tubingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University General Hospital of Ioannina

    Ioannina, 45500, Greece

  • University General Hospital of Larissa

    Larissa, 41110, Greece

  • University General Hospital of Patras

    Pátrai, 26504, Greece

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100, Greece

  • University Hospital, Kyoto Prefectural University of Medicine

    Kyoto, Kyoto, 602-8566, Japan

  • University of Alberta

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Fukui Hospital

    Yoshida-gun, 910-1193, Japan

  • University of Miami Miller School of Medicine

    Miami, Florida, 33136, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, Pomeranian Voivodeship, 80-952, Poland

  • Uniwersyteckie Centrum Kliniczne, Klinika Hematologii I Transplantologii, Budynek Centrum Medycyny N

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Vseobecna Fakultni Nemocnice V Praze

    Prague, 128 08, Czechia

  • Weill Cornell Medical Center

    New York, New York, 10021, United States

  • Weill Cornell Medical Center - Monitoring Location

    New York, New York, 10021, United States

  • Winship Cancer Institute, Emory University

    Atlanta, Georgia, 30322, United States

  • Xuanwu Hospital Capital Medical University

    Beijing, Beijing Municipality, 100053, China

  • Yokohama City University Hospital

    Yokohama, 232-0024, Japan

  • ZIV Medical Center

    Safed, 13100, Israel

  • Zaklad Diagnostyki Obrazowej SOR

    Opole, 45-061, Poland

Conditions

Explore the condition pages connected to this study.