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New drug duo aims to shrink lung tumors in First-Line trial

NCT ID NCT07353957

Recruiting now Disease control Sponsor: Merus B.V. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether adding petosemtamab to the standard immunotherapy pembrolizumab can shrink tumors in adults with metastatic non-small cell lung cancer. About 180 participants will receive the combination as their first treatment. The study focuses on how many patients respond and how long the benefit lasts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Petosemtamab and pembrolizumab

What this could lead to

If successful, this combination could offer a new first-line treatment option for people with advanced non-small cell lung cancer, potentially improving tumor shrinkage rates.

What could go wrong

This is an early-phase trial with only 180 participants, so results may not apply to everyone. The combination may cause side effects or not work better than existing treatments.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG CANCER - NON SMALL CELL NON-SQUAMOUS LUNG CANCER - NON SMALL CELL SQUAMOUS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Australia Site 1

    RECRUITING

    Frankston, Victoria, 3199, Australia

  • CHU Brest Hopital la Cavale Blanche

    RECRUITING

    Brest, 29609, France

  • Centre Hospitalier Intercommunal de Creteil (CHIC)

    RECRUITING

    Créteil, 94000, France

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, 28645, South Korea

  • Clinica Universidad de Navarra - Pamplona

    RECRUITING

    Pamplona, 31008, Spain

  • Flinders Medical Centre

    RECRUITING

    Bedford Park, South Australia, 5042, Australia

  • Florida Cancer Specialists - North

    RECRUITING

    St. Petersburg, Florida, 33701-4553, United States

    Contact Email: •••••@•••••

  • HC Hospitales SL

    RECRUITING

    Marbella, 29660, Spain

  • Hopital Nord Laennec

    RECRUITING

    Nantes, 44093, France

  • Hospital Alvaro Cunqueiro

    RECRUITING

    Vigo, 36312, Spain

  • Hospital Quironsalud Malaga

    RECRUITING

    Málaga, 29004, Spain

  • Hospital Universitario de Navarra

    RECRUITING

    Pamplona, 31008, Spain

  • ICM - Montpellier Cancer Institute

    RECRUITING

    Montpellier, 34298, France

  • Kyungpook National University Chilgok Hospital

    RECRUITING

    Daegu, 41404, South Korea

  • Leiden University Medical Center

    RECRUITING

    Leiden, 2333, Netherlands

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    Long Island City, New York, 11101, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • START - Rioja

    RECRUITING

    Logroño, 26006, Spain

  • Severance Hospital - Yonsei University Health System

    RECRUITING

    Seoul, 3722, South Korea

  • Tennessee Site 1

    RECRUITING

    Nashville, Tennessee, 37209, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tennessee Site 2

    RECRUITING

    Chattanooga, Tennessee, 37403, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Catholic University of Korea, St. Vincents Hospital

    RECRUITING

    Suwon, 16247, South Korea

  • Universita degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi

    RECRUITING

    Florence, 50134, Italy

  • Virginia Site 1

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Virginia Site 2

    RECRUITING

    Blacksburg, Virginia, 24060, United States