Pertussis booster study: does your first vaccine matter?
NCT ID NCT04300192
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study in South Africa looked at 273 children who received a Tdap-IPV booster vaccine. Researchers wanted to see if the type of pertussis vaccine they got as babies affected their immune response. The study measured antibodies and cell-mediated immunity over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tdap-IPV vaccine (tetanus, diphtheria, acellular pertussis, and polio)
What this could lead to
If successful, this could help optimize pertussis vaccination schedules for better long-term protection.
What could go wrong
This is a completed Phase 4 study focused on immune response, not on preventing disease. Results may not apply to other populations or vaccines.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Investigational Site Number : 7100001
Cape Town, 7925, South Africa
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Investigational Site Number : 7100002
Middelburg, 1055, South Africa
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Investigational Site Number : 7100003
Johannesburg, 1619, South Africa