Tailored timing of radioactive therapy may boost tumor control in NETs

NCT ID NCT05387603

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial tests whether personalizing the schedule of a radioactive drug (177Lu-DOTATOC) improves outcomes for people with advanced neuroendocrine tumors. About 300 participants will receive either a standard or personalized treatment plan, with some also taking capecitabine. The goal is to see if tailoring therapy extends the time before tumors grow again.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

177Lu-DOTATOC (a radioactive drug) and capecitabine (a chemotherapy pill)

What this could lead to

If successful, this could show that personalizing the timing of radioactive therapy improves how long tumors stay controlled, with fewer side effects.

What could go wrong

This is a large phase 3 trial, but personalization may not significantly improve outcomes over standard care. Radioactive therapy carries risks like kidney damage and low blood counts.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

neuroendocrine neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Accademical Hospital, Uppsala, Dept. of Oncology

    RECRUITING

    Uppsala, SE-752 37, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Karolinska University Hospital, Dept. of Oncology

    RECRUITING

    Stockholm, SE-171 76, Sweden

    Contact Phone: •••-•••-••••

    Contact

  • Sahlgrenska University Hospital, Dept. of Oncology

    RECRUITING

    Gothenburg, Sweden

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Skåne University Hospital, Dept. of Oncology

    RECRUITING

    Lund, SE-226 52, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact