Gene-Tailored vitamins may shield Moms-to-Be from dangerous hypertension

NCT ID NCT04723836

First seen Oct 31, 2025 · Last updated May 24, 2026 · Updated 29 times

Summary

This study tests whether giving extra riboflavin (vitamin B2) and folate to pregnant women with a specific gene variant can prevent high blood pressure. About 2250 women in early pregnancy will be screened for the MTHFR gene, and those with the TT or CT variant will receive supplements or placebo until delivery. The goal is a simple, non-drug way to protect both mother and baby from pregnancy-related hypertension.

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Contacts and locations

Locations

  • Letterkenny University Hospital

    Letterkenny, Ireland

  • Northern Health and Social Care Trust

    Coleraine, N.Ireland, BT52 1HS, United Kingdom

  • Western Health and Social Care Trust

    Londonderry, N.Ireland, BT47 6SB, United Kingdom

Conditions

Explore the condition pages connected to this study.