Immunotherapy plus chemotherapy before surgery shows promise against tough stomach cancers
NCT ID NCT07699939
First seen Jul 13, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This trial investigates whether adding the immunotherapy drug serplulimab (HLX10) to standard chemotherapy (S-1 and oxaliplatin) before and after surgery can improve outcomes for people with locally advanced, PD-L1-positive stomach or gastroesophageal junction cancer. Participants are randomly assigned to receive either the combination or chemotherapy alone, and the main goal is to see if the combination leads to a higher rate of complete tumor disappearance at the time of surgery. The study is double-blind and placebo-controlled to ensure reliable results.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- serplulimab (HLX10) plus S-1 and oxaliplatin
- What this could lead to
- If successful, this combination could become a new standard treatment to shrink tumors before surgery and reduce the chance of cancer returning in patients with advanced gastric cancer.
- What could go wrong
- This is a phase 2 trial with 136 participants, so results are preliminary. Adding immunotherapy to chemotherapy may increase side effects, and the benefit may not be confirmed in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ajou University Hospital
NOT_YET_RECRUITINGSuwon, Gyeonggi-do, South Korea
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Asan Medical Center
NOT_YET_RECRUITINGSongpa-dong, South Korea
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Cancer Institute Hospital of JFCR
NOT_YET_RECRUITINGKoto-Ku, Tokyo, Japan
Contact Phone: •••-•••-••••
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Chiba Cancer Center
RECRUITINGChiba, Chiba, 260-8717, Japan
Contact Phone: •••-•••-••••
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Gifu University Hospital
NOT_YET_RECRUITINGGifu, Gifu, Japan
Contact Phone: •••-•••-••••
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Gunma University Hospital
NOT_YET_RECRUITINGMaebashi, Gunma, Japan
Contact Phone: •••-•••-••••
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Hiroshima University Hospital
NOT_YET_RECRUITINGHiroshima, Hiroshima, Japan
Contact Phone: •••-•••-••••
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Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
NOT_YET_RECRUITINGYokohama, Kanagawa, Japan
Contact Phone: •••-•••-••••
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Kyushu Cancer Center
NOT_YET_RECRUITINGFukuoka, Fukuoka, 811-1395, Japan
Contact Phone: •••-•••-••••
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National Cancer Center Hospital
RECRUITINGChuo Ku, Tokyo, 104-0045, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cancer Center Korea
NOT_YET_RECRUITINGGoyang-si, Gyeonggi-do, South Korea
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Osaka International Cancer Institute
NOT_YET_RECRUITINGOsaka, Osaka, Japan
Contact
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Osaka Medical and Pharmaceutical University Hospital
NOT_YET_RECRUITINGTakatsuki, Osaka, Japan
Contact Phone: •••-•••-••••
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Saitama Medical University International Medical Center
NOT_YET_RECRUITINGHidaka, Saitama, Japan
Contact Phone: •••-•••-••••
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Saitama Prefectural Cancer Center
NOT_YET_RECRUITINGIna, Kitaadachi-gun, Japan
Contact Phone: •••-•••-••••
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Seoul St. Mary's Hospital
NOT_YET_RECRUITINGSeocho, Seoul, South Korea
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Shizuoka Cancer Center
NOT_YET_RECRUITINGNagaizumi-chō, Sunto-gun, Japan
Contact Phone: •••-•••-••••
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St. Marianna University Hospital
RECRUITINGKawasaki, Kanagawa, Japan
Contact Phone: •••-•••-••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Triple-Drug attack slow down stomach cancer?
- Can a Three-Drug cocktail shrink stomach tumors before surgery?
- Can a less extensive stomach surgery preserve appetite better?
- New drug combo aims to outperform immunotherapy in Hard-to-Treat stomach cancer
- Breath of life: new test could sniff out gut cancers before they spread
- Drug cocktail aims to shrink Hard-to-Treat stomach cancers