Could a simple drug combo reverse jaw bone damage from common medications?

NCT ID NCT03040778

Ongoing Disease control Sponsor: University of Washington Source: ClinicalTrials.gov ↗

First seen May 07, 2026 · Last updated May 08, 2026 · Updated 1 time

Summary

This study tests whether a combination of two drugs (pentoxifylline and tocopherol, a form of vitamin E) can help heal jaw bone damage caused by medications for osteoporosis or cancer. About 100 adults with this condition will receive either the drug combo plus standard care, or standard care alone. The main goal is to see if the exposed bone area shrinks after one year of treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

New York Center for Orthognathic and Maxillofacial Surgery

Lake Success, New York, 11042, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35242, United States
University of Michigan

Ann Arbor, Michigan, 48109-0018, United States
University of Washington

Seattle, Washington, 98195, United States

Conditions

Explore the condition pages connected to this study.

AVASCULAR NECROSIS BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW MEDICATION RELATED OSTEONECROSIS OF THE JAW