New drug may help children with shock by fixing tiny blood vessels
NCT ID NCT07519226
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether penehyclidine hydrochloride can improve microcirculation in critically ill children with shock better than the standard drug atropine. 98 children aged 28 days to 18 years who still had poor blood flow despite stable blood pressure took part. The main goal was to see how quickly capillary refill time improved.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
penehyclidine hydrochloride
What this could lead to
If it works, this could offer a better way to restore tiny blood vessel function in children with shock, potentially improving recovery.
What could go wrong
This is a small, single-center study with only 98 participants. Results may not apply to all children, and the drug may not prove better than standard care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Tissue Perfusion Pressure in Shock: NCT07670390
- Cardiac output device comparison study NCT02728791
- Fecal Lactate Study in Critically Ill Patients | NCT07658001
- Digital heart shock management trial (NCT07085221)
- Hemodynamic Effect of Hydroxocobalamin in Shock NCT04964492
- CRUISE Helicopter Shock Study (NCT07637240)
Contacts and locations
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Locations
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Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, 510000, China