Promising combo tackles Hard-to-Treat GI cancers

NCT ID NCT03095781

First seen May 23, 2026 · Last updated May 23, 2026

Summary

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and XL888 (a targeted therapy)—in 47 people with advanced gastrointestinal cancers that had spread or couldn't be removed. The main goal was to find the safest dose and check for side effects. Researchers also looked at whether the tumors shrank. This study helps guide future research, but it does not offer a cure.

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Contacts and locations

Locations

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Emory University/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.