New hope for kids with stubborn hodgkin lymphoma

NCT ID NCT03407144

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help children and young adults with newly diagnosed Hodgkin lymphoma who are not responding well enough to initial chemo alone. The trial will enroll about 340 participants to see if this combination improves treatment response and survival while monitoring safety. It focuses specifically on patients whose cancer shows a 'slow early response' to the first rounds of chemotherapy.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Albert Alberts Stem Cell Transplant Centre ( Site 0324)

Pretoria, Gauteng, 0044, South Africa
Alliance for Childhood Diseases ( Site 0064)

Las Vegas, Nevada, 89135, United States
Arkansas Children's Hospital ( Site 0046)

Little Rock, Arkansas, 72202, United States
Arnold Palmer Hospital ( Site 0065)

Orlando, Florida, 32806, United States
Athens Childrens Hospital Aglaia Kyriakou ( Site 0361)

Athens, Attica, 115 27, Greece
Azienda Ospedaliera Santobono - Pausilipon ( Site 0402)

Naples, 80123, Italy
CHU de Bordeaux. Hopital Pellegrin ( Site 0447)

Bordeaux, Gironde, 33000, France
CHU de Marseille Hopital de la Timone Enfants ( Site 0449)

Marseille, Bouches-du-Rhone, 13005, France
Centro di Riferimento Oncologico CRO ( Site 0404)

Aviano, Pordenone, 33081, Italy
Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum ( Site 0413)

Berlin, 13353, Germany
Children's Healthcare of Atlanta at Egleston ( Site 0033)

Atlanta, Georgia, 30322, United States
Children's Hospital - Colorado ( Site 0028)

Aurora, Colorado, 80045, United States
Children's Hospital of Alabama ( Site 0023)

Birmingham, Alabama, 35233, United States
Children's Hospital of Michigan ( Site 0056)

Detroit, Michigan, 48201, United States
Children's Hospitals and Clinics of Minnesota ( Site 0036)

Minneapolis, Minnesota, 55404, United States
Children's Medical Center ( Site 0030)

Dallas, Texas, 75235, United States
Children's National Medical Center ( Site 0090)

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center ( Site 0035)

Cincinnati, Ohio, 45229, United States
Cohen Children's Medical Center of New York ( Site 0052)

New Hyde Park, New York, 11040, United States
Columbia University/Herbert Irving Cancer Center ( Site 0063)

New York, New York, 10032, United States
Connecticut Children's Medical Center ( Site 0045)

Hartford, Connecticut, 06106, United States
Dell Children's Medical Center Of Central Texas ( Site 0058)

Austin, Texas, 78723, United States
Fakultni nemocnice v Motole ( Site 0356)

Prague, 150 06, Czechia
Hackensack University Medical Center ( Site 0026)

Hackensack, New Jersey, 07601, United States
Hematologica Alta Especialidad ( Site 0532)

Huixquilucan, 52787, Mexico
Hopital Universitaire Robert Debre ( Site 0446)

Paris, 75019, France
Hopital d'Enfants Armand Trousseau ( Site 0443)

Paris, 75012, France
Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 0507)

Curitiba, Paraná, 81520-060, Brazil
Hospital Infantil Universitario Nino Jesus ( Site 0433)

Madrid, 28009, Spain
Hospital Infantil de Mexico Federico Gomez ( Site 0535)

Mexico City, Mexico City, 06720, Mexico
Hospital Pablo Tobon Uribe-Hematology ( Site 0565)

Medellín, Antioquia, 05034, Colombia
Hospital Universitari Vall d Hebron ( Site 0432)

Barcelona, 08035, Spain
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 0531)

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario La Paz ( Site 0434)

Madrid, 28046, Spain
Hôpital Jeanne de Flandre ( Site 0450)

Lille, Nord, 59037, France
IRCCS Ospedale Pediatrico Bambino Gesu ( Site 0400)

Roma, 00165, Italy
Inova Fairfax Hospital ( Site 0031)

Falls Church, Virginia, 22042, United States
Institut Gustave Roussy ( Site 0445)

Villejuif, Val-de-Marne, 94800, France
Institut d'Hematologie-Oncologie Pediatrique (IHOP) ( Site 0448)

Lyon, Auvergne-Rhône-Alpes, 69008, France
Instituto Nacional De Cancerologia ( Site 0566)

Bogotá, Bogota D.C., 111511, Colombia
Instituto de Oncologia Pediatrica - GRAACC - Unifesp ( Site 0500)

São Paulo, 04023-062, Brazil
Johns Hopkins University ( Site 0025)

Baltimore, Maryland, 21287, United States
Kaiser - Fontana ( Site 0083)

Fontana, California, 92335, United States
Kaiser - Orange County ( Site 0084)

Anaheim, California, 92806, United States
Kaiser Permanente ( Site 0082)

Downey, California, 90242, United States
Kaiser Permanente - Oakland ( Site 0047)

Oakland, California, 94611, United States
Kaiser Permanente - Roseville ( Site 0080)

Roseville, California, 95661, United States
Kaiser Permanente - Santa Clara ( Site 0079)

Santa Clara, California, 95051, United States
Kaiser Permanente Downey Medical Center ( Site 0024)

Los Angeles, California, 90027, United States
Karmanos Cancer Institute ( Site 0002)

Detroit, Michigan, 48201, United States
Klinikum der Universitaet Muenchen-Campus Innenstadt ( Site 0414)

Munich, Bavaria, 80337, Germany
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0510)

Natal, Rio Grande do Norte, 59075-740, Brazil
Medi-K Cayala ( Site 0544)

Guatemala City, 01016, Guatemala
Memorial Regional Hospital/Joe DiMaggio Children's Hospital ( Site 0048)

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center ( Site 0060)

New York, New York, 10065, United States
MemorialCare Health System - Long Beach Medical Center-Cherese Mari Laulhere Children's Village ( Si

Long Beach, California, 90806, United States
Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute ( Site

San Antonio, Texas, 78229, United States
Narodny ustav detskych chorob ( Site 0372)

Bratislava, Bratislava Region, 833 40, Slovakia
Nationwide Children's Hospital ( Site 0037)

Columbus, Ohio, 43205-2696, United States
Oncomedica ( Site 0545)

Guatemala City, 01010, Guatemala
Oncomédica S.A.S ( Site 0527)

Montería, Departamento de Córdoba, 230001, Colombia
Organizacion Clinica Bonnadona-Prevenir S.A.S. ( Site 0529)

Barranquilla, Atlántico, 080020, Colombia
Ospedale Infantile Regina Margherita ( Site 0401)

Torino, 10126, Italy
Phoenix Childrens Hospital ( Site 0034)

Phoenix, Arizona, 85016, United States
Prinses Maxima Centrum ( Site 0461)

Utrecht, 3584 CS, Netherlands
Riley Hospital for Children ( Site 0091)

Indianapolis, Indiana, 46202, United States
Roswell Park Cancer Institute ( Site 0040)

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey ( Site 0027)

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center ( Site 0222)

Seoul, 06351, South Korea
Seattle Childrens Hospital ( Site 0022)

Seattle, Washington, 98105, United States
Severance Hospital Yonsei University Health System ( Site 0221)

Seoul, 03722, South Korea
St. Francis Hospital Cancer Center ( Site 0001)

Greenville, South Carolina, 29607, United States
St. Louis Children's Hospital ( Site 0038)

St Louis, Missouri, 63110, United States
Texas Children's Hospital ( Site 0042)

Houston, Texas, 77030, United States
UMAE Hospital de Especialidades - CMN La Raza ( Site 0536)

Azcapotzalco, 02990, Mexico
UNC Lineberger Comprehensive Cancer ( Site 0044)

Chapel Hill, North Carolina, 27514, United States
Unidad Nacional de Oncologia Pediatrica ( Site 0542)

Guatemala City, 01011, Guatemala
Universita degli Studi di Roma La Sapienza ( Site 0403)

Roma, Abruzzo, 00161, Italy
Universitaetsklinikum Essen ( Site 0415)

Essen, North Rhine-Westphalia, 45147, Germany
Universitaetsklinikum Giessen und Marburg GmbH ( Site 0411)

Giessen, Hesse, 35392, Germany
University College London Hospitals NHS Foundation Trust ( Site 0454)

London, London, City of, NW1 2PG, United Kingdom
University General Hospital of Thessaloniki "AHEPA" ( Site 0363)

Thessaloniki, Central Macedonia, 546 36, Greece
University of Athens - Aghia Sophia Childrens Hospital ( Site 0362)

Athens, Attica, 115 27, Greece
University of Chicago ( Site 0066)

Chicago, Illinois, 60637, United States
University of Florida ( Site 0051)

Gainesville, Florida, 32610, United States
University of Kentucky Markey Cancer Center ( Site 0057)

Lexington, Kentucky, 40536-0293, United States
University of Louisville-Norton Children's Hospital ( Site 0059)

Louisville, Kentucky, 40202, United States
Universitätsklinikum Münster - Albert Schweitzer Campus-Pädiatrische Hämatologie und Onkologie ( Sit

Münster, North Rhine-Westphalia, 48149, Germany
Vanderbilt University Medical Center-Ingram Cancer Center ( Site 0054)

Nashville, Tennessee, 37232, United States
Weill Cornell Medicine ( Site 0032)

New York, New York, 10065, United States
Wits Clinical Research ( Site 0321)

Soweto, Gauteng, 2193, South Africa
Wits Clinical Research ( Site 0323)

Johannesburg, Gauteng, 2193, South Africa
Yale Cancer Center ( Site 0061)

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

HODGKIN LYMPHOMA